[Hemosorption in systemic vasculitis]. / Gemosorbtsiia pri sistemnykh vaskulitakh.

The present work summarises the experience gained with the use of extracorporeal hemoperfusion in 45 patients suffering from rheumatic diseases. During hemoperfusion, there was a decrease in the initially activated LDH, CPK, AST, ALT and AP. The reduction of the content of phospholipids and cholesterol in plasma and red blood cells is assessed as an adverse effect of hemoperfusion, since the content of phospholipids and cholesterol was under normal before hemoperfusion. The changes indicated point to the necessity of administering antioxidants and exogenous phospholipids.

[Correction of microcirculatory disorders in rheumatic diseases]. / Korrektsiia narusheniia mikrotsirkuliatsii pri revmaticheskikh zabolevaniiakh.

The present article is concerned with the problems of pharmacotherapy of microcirculatory disorders (MD) in rheumatic diseases (RD) and with the complex of methods permitting one to judge the intensity of the pathological process at the microcirculatory level. Based on the study of the problems of the correction of MD in more than 300 patients with RD the vasospastic, ischemic, cutaneotrophic, renal and pulmorenal syndromes as well as the DIC syndrome were recognized which require the correction therapy. Differentiated therapy including heparin, deaggregating agents, rheopolyglucin and peripheral vasodilators should be performed with regard to the degree of blood rheological properties derangement and tendency of alterations in the hemostatic potential. To evaluate the treatment, efficacy, biomicroscopy of the vessels of the eyeball conjunctiva and laboratory standardized methods for hemostasis study are the most available techniques.

[Hemosorption in the complex treatment of rheumatic diseases]. / Gemosorbtsiia v kompleksnoi terapii revmaticheskikh zabolevanii.

The authors describe the results of the use of hemosorption in combined treatment of 42 patients with rheumatic diseases. The main group comprised patients with thromboangitis obliterans (23), nonspecific aortoarteritis was recognized in 6 cases, systemic scleroderma and systemic lupus erythematosus in 4, nodular periarteritis in 2. The functional skin tests were made with the aid of the KDU-3 unit, the level of the peripheral blood flow was measured with tetrapolar rheography and impedometry. The degree of redox processes and oxygen tension in the tissues was studied by the polarographic technique, the character of microcirculatory processes with the aid of biomicroscopy of the eyeball conjunctiva, the intensity of immunologic shifts by means of precipitation with polyethylene glycol at different dilutions. In addition, alterations in cellular and serum enzymes were also examined. The data obtained suggest that hemosorption is one of the effective additional methods of the treatment of patients with rheumatic diseases.

Pathological and adaptive vascular changes in the microcirculatory bed according to morphological and biomicroscopic findings.

Using non-injection methods (membrane silvering, their staining with Sudan black B or Schiff's reagent) and using conjunctival microscopy, the state of microcirculation in various diseases was investigated on autopsy material (162 observations) and in vivo (78 patients). On the basis of the results the authors deduce general principles of the description and functional evaluation of pathological changes in the microcirculatory system, and divide them into vascular, intravascular and extravascular (stromal) ones. They stress that besides pathological changes proper it is necessary to differentiate also adaptive changes in the microvascular structure, changes in rheological properties of blood and in the interstitium. It is recommended to apply the same principles in description and functional evaluation of the findings of biomicroscopic examination of microcirculation in clinical practice.

[Ways of improving the therapeutic management of angiosurgical patients in a specialized vascular surgery department]. / Puti sovershenstvovaniia terapevticheskogo lecheniia angiokhirurgicheskikh bol'nykh v spetsializirovannom otdelenii sosudistoi khirurgii.

Many years of experience of the Yaroslavl Interregional Vascular Centre suggests that better therapeutic support at vascular surgery units may be one of approaches to improving current specialized angiosurgical care. Collaboration of angiosurgeons and therapeutists, and drug correction of possible disorders and complications before and after vascular reconstructive surgery is expected to contribute to better outcomes of treatment in patients with acute and chronic pathologic developments in arteries and veins.

[Pathology of the microcirculation in Schönlein-Henoch disease according to morphological and biomicroscopic data]. / Patologiia mikrotsirkuliatsii pri bolezni Shenleina-Genokha po dannym morfologii i biomikroskopii.

The state of microcirculation in hemorrhagic vasculitis was studied by morphological methods and conjunctival biomicroscopy. Inflammatory, sclerotic, and ataptative changes in terminal vessels of the internal organs and serous membranes are described. The systemic pattern of vascular pathology and selective vulnerability of the venular part (postcapillaries predominantly) in this disease were demonstrated. Morphological data reflecting the functional insufficiency (decompensation) of the local hemo- and lymph-dynamics are presented. A relative comparability of postmortem and biomicroscopic structural changes in the vessels of the microcirculatory bed was established. The method of conjunctival biomicroscopy is considered to be useful clinically not only for the elucidation of the extent of vasculitis activity but also for the evaluation of the effectiveness of treatment.

[State of the microcirculation in periarteritis nodosa based on morphological and biomicroscopic data]. / Sostoianie mikrotsirkuliatsii pri uzelkovom periarteriite po dannym morfologii i biomikroskopii.

The status of microcirculation in periarteritis nodosa was studied by impregnation method (serous membranes) and biomicroscopy (eyeball conjunctiva). Pathological and adaptative changes in terminal vessels were found. It is suggested that the involvement of microcirculation ways in this disease is systemic and that morphological changes in microvessels are comparable to biomicroscopic changes.