[The placental growth factor and fms-similar tyrosine kinase-1 as markers of pre-eclampsy in dynamics of pregnancy].

The article presents reference limits of concentrations of placental growth factor and fms-similar tyrosine kinase-1 and values of their ratio in dynamics of physiologic pregnancy and in female patients with pre-eclampsy of different degree of severity in 1 and III trimesters of pregnancy. It is established that in female patients with pre-eclampsy ratio of fms-similar tyrosine kinase-1 and placental growth factor significantly exceed ratio in female patients with physiological course of pregnancy. The degree of increase of values of ration between fms-similar tyrosine kinase-1 and placental growth factor correlates with degree of severity of pre-eclampsy.

[The determination of CA-125, CA-19-9 and CEA antigens in gynecologic patients for differential diagnosis and the assessment of the efficacy of surgical treatment and subsequent monitoring]. / Opredelenie antigenov CA 125, CA 19-9 i REA u ginekologicheskikh bol'nykh dlia differentsial'noi diagnostiki i otsenki éffektivnosti operativnogo lecheniia i posleduiushchego monitoringa.

Tumor markers CA 125, CA 19-9, and carcinoembryonic antigen (CEA) were measured in the blood sera of 396 inpatients of different age. In 139 patients the measurements were carried out over time. Hoffman La Roche enzyme immunoassay test kits were used. Eight groups of women were tested: controls without gynecological diseases, women in need of plastic repair of the genitals, patients with inflammatory diseases, with cervical endometriosis, internal endometriosis, ovarian endometriosis, uterine myoma, benign ovarian tumors, and malignant tumors of the ovaries. The results indicate a relatively high diagnostic value of measuring CA 125 in gynecological patients, particularly in those with endometriosis. Parallel measurements of three markers in the blood serum (CA 125, CA 19-9, and CEA) are more informative for the differential diagnosis of endometriosis and malignant tumors. Follow-up of CA 125 concentration may be used to assess the efficacy of therapy and help early detect the disease recurrences.

[Features of the endometrial steroid receptor system in habitual abortion with high risk of infectious complications]. / Osobennosti steroidretseptornogo apparata éndometriia pri privychnom nevynashivanii beremennosti s vysokim riskom infektsionnykh oslozhnenii.

Analysis of microbiologic and histologic findings and measurements of estrogen and gestagen receptors in the endometrium have shown manifest shifts in the endometrial steroid receptor system in women with asymptomatic chronic endometritis. The authors claim that disordered reception of steroid hormones may be regarded as one of the causes of spontaneous, abortions.

[Pulsed secretion of gonadotropins in polycystic ovary syndrome]. / Izuchenie impul'snogo kharaktera sekretsii gonadotropinov pri sindrome polikistoznykh iaichnikov.

Pulsed secretion of gonadotropins was studied in 8 women suffering from polycystic ovarian syndrome, aged 23-28. Data on the time course of LH and FSH levels were processes by Santen and Bardin's method and by harmonic analysis. The results evidence that regular ejections of LH at a frequency higher than circahoralian rhythm (about 2 impulses per h) in such patients may be the cause of the development of the polycystic ovarian syndrome. Therapy with norcolut, carried out for 3 months, resulted in development of a trend to normalization of LH secretion, FSH secretion remaining unchanged.

[The hormonal status and steroid receptor system of the endometrium in patients with benign tumors and endometrioid cysts of the ovaries]. / Gormonal'nyi status i steroidretseptornaia sistema éndometriia u patsientok s dobrokachestvennymi opukholiami i éndometrioidnymi kistami iaichnikov.

Plasma concentrations of protein hormones (LH, FSH, prolactin) and steroid hormones (estradiol, progesterone, testosterone, cortisol) have been assayed during the follicular and luteal phase of the cycle in patients with benign cysts and endometrioid cysts of the ovaries. Endometrial estradiol and progesterone receptors were also examined in these patients in the midluteal phase. These studies described steroid and gonadotropic hormone secretion of both the luteal and follicular phase in the two populations, as well as steroid receptors of the secretory endometrium. The most serious abnormalities were found in the endometrium of the patients with endometrioid ovarian cysts. These disorders suggest their relationship with infertility in the patients with benign ovarian neoplasms.

[Effectiveness of hormonal therapy of endometrioid ovarian cysts]. / Effektivnost' gormonal'noi terapii pri éndometrioidnykh kistakh iaichnikov.

Patients with ovarian endometriosis have been examined during the follicular and luteal phase of the ovulatory and the second phase of the anovulatory cycles. Estradiol and progesterone blood concentrations measured on operation days and during the respective ovulatory phases were in a normal range. Ovulation and endometrial hyperplasia reduced basal progesterone concentrations. Comparison of findings on steroid receptor systems in the endometrium and endometrioid ovarian cysts indicated that they were identical. The findings were different in ovulation and endometrial hyperplasia. These patterns provided criteria for endometrial response to female sex hormones by assaying endometrial intracellular steroid receptor systems in normally ovulating patients with ovarian endometriosis.

[Prospects of the use of neoplasm antigens as markers of gynecologic diseases]. / Perspektivy primeneniia rakovykh antigenov v kachestve markerov ginekologicheskikh zabolevanii.

CA-125 antigen was assayed in 108 patients with the most prevalent gynecologic diseases by enzyme immunoassay. Its blood levels were found to be under 35 U/ml in the patients with inflammatory diseases. In endometriosis and benign ovarian tumors CA-125 concentrations in the blood were elevated. Malignant tumors of the ovaries were detected in 80 percent of the examinees. CA-125 levels reduced after surgical treatment in 72 percent of patients. These data permit a conclusion that CA-125 diagnostic agent may be used to monitor the course of the postoperative period and assess the late results of treatment.

[Interaction of labeled estrogens with receptors in the cytosol of the human uterus]. / Vzaimodeistvie mechenykh éstrogenov s retseptorami v tsitozole matki cheloveka.

A comparative study of binding of labelled estrone, estradiol, ethinylestradiol and estriol was conducted in uterine cytosol of postmenopausal women.

[Interaction of pregna-D'-pentaranes--pentacyclic derivatives of progesterone--with gestagen-binding sites of uterine cytosol]. / Vzaimodeistvie pregna-D'-pentaranov--pentatsiklicheskikh proizvodnykh progesterona--s gestagensviazyvaiushchimi mestami tsitozolia matki.

The interaction of promegestone (R-5020), progesterone (P) and its derivatives having and additional carbocyclic D' (pregna-D'-pentrans) with progestin-binding cytosol system of the uterus was studied in different species (rabbits, rats, guinea-pigs and men). A comparative analysis of the competitive binding data for the mentioned compounds has shown interspecies differences in ligand specificity. Two types of binding sites for 3H-D'-pentran (in contrast to R-5020 and P) have been detected in rabbit uterus cytosol, both in intact and estrogenized animals. However, in rabbits, estrogenization altered the values of the apparent equilibrium constants and binding capacities. At the same time, the interaction of pentran with progestin-binding sites in guinea-pig and human uterus cytosol is nonspecific. It is suggested that the features of the interaction of 3H-D'-pentran with its binding sites in rabbit uterus cytosol may be determined by an increase in hydrophobic bond.

[Effect of danazol on the function of the estrogen and progesterone receptor systems of the human endometrium]. / Vliianie danazola na sostoianie éstrogen- i progesteron-retseptornykh sistem éndometriia cheloveka.

Quantity of estrogen- and progesterone-specific binding sites was measured in endometrial tissues of 10 females treated with danazol during 3 month in a dose of 400 mg per day after surgical treatment for endometriosis. It was demonstrated that the amount of estrogen receptors in endometrium of the patients was the same as in endometrial tissue of healthy females but the quantity of nuclear progesterone receptors was markedly increased.

[Comparative analysis of the interaction of various estrogens with the estrogen-receptor system of the uterus]. / Sravnitel'nyi analiz vzaimodeistviia razlichnykh éstrogenov s éstrogen-retseptornoi sistemoi matki.

Equilibrium binding of labeled estron, estradiol, estriol and DES was studied in uterine cytosol of immature Wistar rats. The dissociation kinetics of the ligand complexes with specific high affinity sites suggested the homogeneity of estrogen receptors in rat uterine cytosol. The feasibility of intracellular regulation of estrogen action in target cells both at the receptor and post-receptor levels is discussed.