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Izv Akad Nauk Ser Biol ; (4): 403-10, 2010.
Article in Russian | MEDLINE | ID: mdl-20799640

ABSTRACT

Comparative study of chitosan wound healing properties and its synthesized derivatives in MC-100 gel was carried out using the model of experimental full thickness skin wounds. It was determined that N-sulfosuccinoyl chitosan derivatives added into the gel in a concentration of 0.05% possess the higher wound healing activity in comparison with other chitosan derivatives and decrease the half-healing period of wounds 2-3 times in comparison with the control.


Subject(s)
Chitosan/analogs & derivatives , Chitosan/pharmacology , Skin/drug effects , Succinates/pharmacology , Wound Healing/drug effects , Animals , Gels , Mice , Skin/injuries , Structure-Activity Relationship
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