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Excretion of himantane and its metabolites with the urine and feces in rats.
Litvin, E A; Bastrygin, D V; Kolyvanov, G B; Alekseyev, K V; Zherdev, V P.
Bull Exp Biol Med ; 153(4): 481-2, 2012 Aug.
Article in English, Russian | MEDLINE | ID: mdl-22977850

ABSTRACT

The levels of himantane and its metabolites in daily urine and feces of rats were measured after intraperitoneal and oral dose of 25 mg/kg. The injected dose of the initial substance and 1.3% its metabolites were eliminated with excrements within 24 h after administration via both routes 0.23%.


Subject(s)
Adamantane/analogs & derivatives , Antiparkinson Agents/metabolism , Antiparkinson Agents/pharmacokinetics , Adamantane/administration & dosage , Adamantane/metabolism , Adamantane/pharmacokinetics , Adamantane/urine , Administration, Oral , Animals , Antiparkinson Agents/administration & dosage , Antiparkinson Agents/urine , Biotransformation , Feces/chemistry , Injections, Intraperitoneal , Mass Spectrometry , Rats , Time Factors
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