ABSTRACT
Abstract Vascular prostheses, excised because of their functional properties loss, were studied. Using different methods there was established, that this complication is caused by the thrombus formation as a reaction of organism on the prosthesis material. The testing procedure on compatibility was proposed, using atomic-power microscope. Components of a patient immunity may identify the prosthesis material and start the rejection mechanisms in case of negative reaction.
Subject(s)
Anastomosis, Surgical/instrumentation , Biocompatible Materials/adverse effects , Blood Vessel Prosthesis , Polytetrafluoroethylene/adverse effects , Prosthesis Failure , Thrombosis/etiology , Blood Coagulation/drug effects , C-Reactive Protein/immunology , C-Reactive Protein/metabolism , Equipment Failure Analysis , Femoral Artery/pathology , Femoral Artery/surgery , Humans , Immunoglobulin G/blood , Materials Testing , Microscopy, Atomic Force , Popliteal Artery/pathology , Popliteal Artery/surgery , Prosthesis Implantation , Retrospective Studies , Surface Properties , Thrombosis/immunology , Thrombosis/pathology , Thrombosis/surgeryABSTRACT
By means of water-soluble carbodiimide coupling technique various bioligands were covalently attached to the surface of uncoated synthetic active carbons and a number of sorbents with certain biological functions were thus designed. Carbonaceous sorbents with immobilized ligands demonstrate increased affinity towards specific sorbates compared to that of starting matrix. As soon as SCN and SCS synthetic carbons are used uncoated they can be highly loaded with protein molecules - up to 80 mg serum albumin, 6-10 mg IgG rabbit etc. per gram of sorbent. Carbonaceous immunosorbents retain biocompatibility and substantial non-specific adsorptive capacity of initial hemosorbents. A conclusion is drawn that uncoated synthetic charcoals can serve a basis for design of selective hemosorbents intended for solving complicated problems of immunocorrection.
