ABSTRACT
A study was made of the therapeutic efficacy of human leukocytic interferon (HLI) and leikinferon in the treatment of HBV- and HDV-infection. 21 patients were placed under observation. Of these, 6 presented with lingering hepatitis B (HB), 8 with chronic HB, 1 was a HBsAg carrier, 4 had Grades I-IV, acute hepatic encephalopathy, and 2 acute hepatitis delta. 15 patients received leikinferon, 6 were given HLI for injections. Indications and schemes for the treatment with interferon preparations are provided as are the clinico-biochemical and serological criteria for estimating the efficacy of interferon therapy. In lingering and chronic forms of HB, leikinferon exerts a beneficial effect. It is not costly, thus enabling one to carry out continuous treatment in patients suffering from chronic forms. HLI may be recommended as an effective agent.
Subject(s)
Cytokines/therapeutic use , Hepatitis B/therapy , Hepatitis D/therapy , Interferon Type I/therapeutic use , Interferon-alpha/therapeutic use , Adolescent , Adult , Aged , Child , Child, Preschool , Cytokines/administration & dosage , Cytokines/adverse effects , Drug Combinations , Drug Evaluation , Female , Hepatitis B/immunology , Hepatitis D/immunology , Humans , Injections, Intramuscular , Interferon Type I/administration & dosage , Interferon Type I/adverse effects , Interferon-alpha/administration & dosage , Interferon-alpha/adverse effects , Male , Middle Aged , Remission Induction , Time FactorsABSTRACT
A study was made of HB-virus infection markers in 438 patients of different age with hepatitis B. Highly sensitive methods based on the test systems manufactured in this country and abroad were employed. The authors established the diagnostic importance of HBV markers, studied the prevalence of those markers in parents of the diseased children of the first year of life, demonstrated the clinico-epidemiological importance of highly sensitive methods of serological diagnosis.
Subject(s)
Hepatitis B/diagnosis , Adult , Aged , Aging/immunology , Female , Hepatitis B/epidemiology , Hepatitis B/transmission , Hepatitis B Antibodies/analysis , Hepatitis B Core Antigens/analysis , Hepatitis B Surface Antigens/analysis , Hepatitis B e Antigens/analysis , Humans , Immunoglobulin M/analysis , Infant , Infant, Newborn , Male , Middle Aged , Serologic Tests/methodsABSTRACT
The detectability of delta-infection among patients with HB virus infections and their effects on the course of hepatitis B are discussed. Anti-delta were detected in 25.2% of 111 patients with HB virus infections. The course of the disease was more severe in cases of combined infection, and delta-superinfection was associated with the clinical picture of CAH, suggesting that combined B + delta infection may be producing a profound liver damage.
Subject(s)
Hepatitis B/complications , Hepatitis D/complications , Adolescent , Adult , Aged , Child , Child, Preschool , Female , Hepatitis Antibodies/analysis , Hepatitis D/diagnosis , Hepatitis D/immunology , Hepatitis Delta Virus/immunology , Humans , Infant , Male , Middle AgedABSTRACT
The paper is concerned with some data on the detection of markers of HBV infection (HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc of IgM class) in 277 HB patients of different age groups using highly sensitive methods based on Soviet assays. A clinical course of HB in patients of different age groups was correlated with the regularities of the detection of markers of HBV infection. The diagnostic and prognostic importance of HBV antigens and antibodies to them was shown in patients of different age groups.
