[Pseudosarcomatous lesions of the urinary bladder. Report of a case]. / Lesiones seudosarcomatosas de vejiga urinaria. Presentación de un caso.

OBJECTIVE: The present study describes a case of pseudosarcomatous lesion of the urinary bladder, a rare disease entity that may occasionally be clinically mistaken for malignant neoplasms. METHODS/RESULTS: A 79-year-old male with hematuria who had previously undergone surgery is described. Cystoscopic examination revealed a tumor which was resected by TUR. The histological analysis disclosed a benign proliferative mesenchymal lesion comprised of spindle cells. CONCLUSIONS: Pseudosarcomatous lesions of the urinary bladder are benign lesions of fibroblastic or myofibroblastic origin that are more frequent in young adults and prevalent in females. Clinically they present with hematuria and treatment is by surgical excision (partial cystectomy or TUR). The prognosis is excellent.

[Study of the expression of proliferating cell nuclear antigen and p185 in non-small cell lung carcinoma]. / Estudio de la expresión del antígeno nuclear de proliferación celular y p185 en el carcinoma no microcítico de pulmón.

We assessed immunohistochemical expression of p185 and the proliferating cell nuclear antigen (PCNA) in 68 patients undergoing surgery for non-small cell lung cancer. Adenocarcinoma of the lung was the histological type whose expression of p185 at levels exceeding 10% was greater to a statistically significant degree. Epidermoid carcinoma, on the other hand, was associated with the highest PCNA indices. Although these 2 markers had no prognostic value in the survival study, it must be pointed out that the longest survivors were patients with p185 expression less than 10% in neoplastic cells.

[Moderately differentiated neuroendocrine carcinoma of the larynx]. / Carcinoma neuroendocrino medianamente diferenciado de laringe. A propósito de un caso.

We present a case of moderately differentiated neuroendocrine carcinoma of the larynx. These tumors represent 0.6% of all laryngeal carcinomas. Histological diagnosis requires the use of immunohistochemical methods, the tumoral cells presenting positivity for epithelial markers (cytokeratin) and neuroendocrine markers (chromogranin). Clinically, their location is supraglottic and they affect mainly males between the 6th-7th decades of life. The prognosis is better than that of squamous carcinoma or adenocarcinoma. The differential diagnosis must be made with granular cell tumor and paragangliomas.

[Lymphoma of the splenic mantle. Morphologic, immunologic and ultrastructural characterization of a case]. / Linfoma del manto esplénico. Caracterización morfológica, inmunológica y ultraestructural de un caso.

We present a splenic primary mantle lymphoma in a 64 year old woman, without peripheral lymphoadenopathy and stage IV at the moment of the diagnosis. Grossly a splenic infiltration was observed. Microscopically, a nodular lymphoma of small lymphocytes proliferating around benign germinal centers makes the diagnosis. Immunohistochemically, tumoral lymphocytes expressed SIgG/kappa and CD5 (Leu-1). Markers of follicular center origin CD10 (CALLA) were negative. According to working formulation mantle-cell lymphoma is considered a lymphoma of intermediate grade of malignancy. In our case, the morphologic, immunologic, ultrastructural findings and clinical evolution were more characteristics of a low grade lymphoma that a intermediate grade of malignancy.