ABSTRACT
Quantitative regularities have been established for mortality and life-span of rats in relation to the pulse recurrence frequency (3-2400 s-1) of electron radiation with electron energies of 25 and 50 MeV. Electrons with pulse recurrence frequencies of 600 and 1200 s-1 have shown a higher biological effectiveness.
Subject(s)
Electrons/adverse effects , Longevity/radiation effects , Animals , Brain Diseases/etiology , Brain Diseases/mortality , Dose-Response Relationship, Radiation , Male , Particle Accelerators , Radiation Injuries, Experimental/complications , Radiation Injuries, Experimental/mortality , Rats , Time FactorsABSTRACT
A comparison between biological effects of electron radiation (25 and 50 MeV) at doses of 100-300 Gy and with pulse recurrence frequencies from 3 to 2400 s-1, using general damage severity, distinctiveness of separate clinical manifestations and incidence of extremely severe forms of radiation sickness as criteria, has demonstrated some peculiarities of radiation pathology in rats under these circumstances. The pulse recurrence frequency influence varies with the criterion applied.
Subject(s)
Electrons/adverse effects , Radiation Injuries, Experimental/etiology , Animals , Brain Diseases/etiology , Dose-Response Relationship, Radiation , Intestinal Diseases/etiology , Male , RatsABSTRACT
Certain peculiarities have been revealed in the development of radiation sickness in guinea pigs subjected to nonuniform irradiation with superlethal doses. With electron and gamma-neutron radiation LD50/1.5 was 116.11 and 114.48 Gy respectively, when delivered to whole body, and 133.40 and 111.72 Gy when delivered to the posterior part of the body.
Subject(s)
Radiation Injuries, Experimental/pathology , Animals , Electrons , Guinea Pigs , Lethal Dose 50 , Male , Neutrons , Radiation Dosage , Radiation Injuries, Experimental/mortalityABSTRACT
The RBE coefficient of neutrons (0.85 MeV) was 1.87 in comparison with that of electron radiation (8 MeV) as determined by the death rate of guinea pigs with the cerebral form of radiation sickness. LD50/1.5 amounted to 43.2 and 80.7 Gy. The dynamics of clinical symptoms at the height of the disease is discussed.
Subject(s)
Brain Diseases/etiology , Fast Neutrons , Neutrons , Radiation Injuries, Experimental/etiology , Animals , Brain Diseases/mortality , Electrons , Fast Neutrons/adverse effects , Gamma Rays , Guinea Pigs , Lethal Dose 50 , Male , Neutrons/adverse effects , Radiation Injuries, Experimental/mortality , Relative Biological EffectivenessABSTRACT
Relative biological effectiveness (RBE) coefficient of 0.85 MeV neutrons was 1.87 in comparison with 0.66 MeV gamma radiation (137Cs) when estimated by the death rate of guinea pigs with intestinal form of radiation sickness. LD50/5 was 5.9 and 11.06 respectively. Features of the mortality rate dynamics, clinical picture and pathoanatomical changes are discussed.
Subject(s)
Intestinal Diseases/etiology , Neutrons , Radiation Injuries, Experimental/etiology , Animals , Gamma Rays , Guinea Pigs , Intestinal Diseases/mortality , Intestinal Diseases/pathology , Male , Radiation Injuries, Experimental/mortality , Radiation Injuries, Experimental/pathology , Relative Biological Effectiveness , Time FactorsABSTRACT
A comparative study was made of the death rate of guinea pigs after neutron (0.85 MeV) and 137Cs-gamma-radiation (0.66 MeV); LD50/30 were 1.58 and 3.44 Gy respectively. CRBE of neutrons was 2.2 as determined by median lethal dose values for guinea pigs.