[Estimation of long-time effects of Chernobyl AES accident on behavior markers in a small rodent population]. / Otsenka otdalennykh posledstvii avarii na ChAES po povedencheskim markeram v populiatsii melkikh gryzunov.

Differences in behaviour reactions in "open field" and glycemia under conditions of immobilisation stress of vole (Microtus oeconomus, Pallas) from two groups ("Yanov" and "Lelev") were investigated. Rodents were ensnared from two populations reproduced for a long time (11 years) in the areas of ChNPP Exclusion Zone with different level of radioactive contamination. The radiation absorbed dose for animals of "Yanov" group (external and internal irradiation) was 11-20 times higher than that of "Lelev" group. Males and females from the area with worse radioecological condition had higher vertical and horizontal locomotion. The level of emotional reactions of "Yanov" males was lower than the "Lelev" one. Statistically significant variation in female emotional reaction was found, but it had not the same directions. In both groups higher locomotion activity and lower emotionality were associated with male sex. The males of both groups showed similar fasting glucose level and glycemic response after 30-min. immobilisation. Our data provide the additional evidence of existence of long-time genetic effects in small rodent populations permanently reproduced on radiation contaminated areas.

[5'-Nucleotidase and adenosine deaminase activity in the rat brain upon prolonged effect of low radiation doses]. / Aktyvnist' 5'-nukleotydazy ta adenozyndezaminazy v mozku shchuriv za umov tryvaloho vplyvu iunizuiuchoho vyprominiuvannia nyz'koï intensyvnosti.

The effect of combined low radiation doses (0.2-50.8 cGy) on the 5'-nucleotidase and adenosine deaminase activities in the rat hypothalamus, hippocamp and cerebral cortex during 45, 120 and 365 days was examined. It has been shown that the changes in the 5'-nucleotidase activity of the hypothalamus and hippocamp have a phase character. The direction of the changes in enzyme activity of the hypothalamus and hippocamp adenosine forming was dependent on the zone stay period and had the exactly opposite character depending on the early and prolonged stay period in the zone. 5'-nucleotidase activity was changed under the influence of mean and lesser doses with an increase of the zone stay period. No changes in the 5'-nucleotidase activity of the cerebral cortex were noted. No changes in the hypothalamic adenosine deaminase activity of rats that stayed in a zone during 45 days were revealed; under the effect of mean dose during 120 days the activity decreased and also in case of a higher dosage during one year. The adenosine deaminase activity in animal hippocamp decreased in rats only under the influence of the lesser dose, for 45-day period. The decrease in adenosine deaminase activity of the cerebral cortex that was noted under the effect of all the three doses during 45 days, the higher and mean doses during 120 days disappeared in a year.

[The trends and intensity of lipid peroxidation processes initiated by the action of "Chernobyl" factors]. / Izuchenie napravlennosti i intensivnosti protsessov perekisnogo okisleniia lipidov, initsiirovannykh deistviem "Chernobyl'skikh" faktorov.

The 45-day's action of nutritional radionuclides (137Cs, 90Sr, 40K) by inside organism irradiation at doses: 0.16 sGy, 0.55 cGy, 5.5 cGy was investigated. The blood, muscles, heart, kidneys, lung, liver, brain, spleen and testis were studied. The content of dienes, trienes, oxodienes, tetraenes conjugates and malondialdehyde were researched. The level of dienes increased in blood and kidneys; MDA--in spleen than more, that more of dose irradiation. Content of oxodienes, trienes and tetraenes (the biological activity eicosanoids) decreased at kidneys, lung, brain and spleen. At total, these parameters by organism's adaptational systems controlled at physiological conditions.

[State of the endocrine system in rats of various ages under immobilization stress and influence of adaptogenic biomos]. / Stan endokrynnoi systemy shchuriv riznogo viku v umovakh immobilizatsiinogo stresu i vplyvu adaptogenu biomosu.

The effect of administration, of BIOMOS-VJ on the concentration of thyroxine, triiodothyronine, corticosterone, insulin and glucose in the blood serum of the normal state and under conditions of immobilization stress of young and aged Wistar's rats has been studied. The experiments have shown that the administration of preparation prevents the appearance of disturbances in endocrine system of the organism typical of stress such as a decrease in concentration of thyroid hormones and insulin and also a considerable increase in corticosterone and glucose concentration in the blood serum. On the basis of the results indicating the influence of BIOMOS-VJ on the endocrine system of young and aged Wistar's rats it is assumed that this preparation has gero-protected properties.

[The effect of grofollon on the induction of sex maturation in female rats]. / Vliianie grofollona na induktsiiu polovozrelosti u krys-samok.

The authors provide the results of experimental studies carried out in immature female rats given the gonadotropin grofollon to stimulate puberty. Grofollon was administered in doses of 20, 30 or 50 units. It was dissolved in a physiological solution or prolongon. The effect of grofollon was found to depend on the dose and type of the solvent. The earliest response (in 6 hours) to grofollon administration was marked by an increase of plasma estradiol. 24 hours after the hormonal treatment there was a rise of the mass of the ovaries and uterus, in particular. The vagina opened on the 3d day. The dissolution of grofollon in prolongon was discovered to enhance the drug efficacy.

[Morphologic and hormonal correlates of true hermaphroditism in the rabbit]. / Morfologicheskie i gormonal'nye korreliaty istinnogo germafroditizma u krolika.

A macro-microscopical and histological investigation of the urogenital system organs of a rabbit-hermophrodite has been performed with an aim to compare the content of sex steroids in the peripheral and in the gonadal blood estimated by means of radioimmunological methods. Certain anomalies have been found out in the development of external and internal sex organs, kidneys and urinary bladder. Testosterone and estradiol concentration in blood flowing from the ovotestis is decreased, as it is in the periphral blood. The rabbit urogenital system organs have been studied from the 12th day of the intrauterine development up to the 10th day of the postnatal life. The results of the investigation performed make it possible to consider that the developmental anomalies in the rabbit-hermophrodite have, evidently, appeared between the 20th--25th days of its intrauterine development as a result of certain disbalance of sex steroids.

[Use of various preparations with beta-adrenergic blocking action in the overall therapy of thyrotoxicosis]. / Primenenie razlichnykh preparatov beta-adrenoblokiruiushchego deistviia v kompleksnoi terapii tireotoksikoza.

Three beta-adrenoblockers (trasicor, alpheprol, isoptin) were used in 68 patients with thyrotoxicosis in the complex therapy of the disease. Their effect on hemodynamic indices, urinary catecholamine excretion were studied, and the results of investigation were compared with the data obtained earlier with the use of anaprylin. The action of the latter on the thyroid metabolism was ascertained. Anaprylin proved to be the most effective of the aforementioned preparations. Trasicor, which was somewhat less effective, could be used in patients with thyrotoxicosis complicated by cardiovascular insufficiency due to its less pronounced inotropic action. Isoptin may be recommended as an anti-arrhythmic agent in thyrotoxicosis. The action mechanism of beta-adrenoblockers in thyrotoxicosis is suggested.