ABSTRACT
Candida albicans is increasingly recognised as a coloniser of the respiratory tract in cystic fibrosis (CF) patients. Yet, the potential role, if any, of the micro-organism in the progress of the disease remains unclear. In this study, we investigated the association between inhaled antibiotics and C. albicans chronic colonisation in patients with CF. A cohort of 121 CF patients born from 1988 to 1996 was, respectively, studied. The medical records of each patient were reviewed from the first time they attended the CF Centre until the occurrence of C. albicans chronic colonisation or their last visit for the year 2010. Chronic colonisation was defined as the presence of C. albicans in more than 50% of cultures in a given year. A number of possible confounders were included in the multivariate logistic regression analysis to identify an independent association between inhaled antibiotics and C. albicans chronic colonisation. Fifty-four (44.6%) of the 121 patients enrolled in the study developed chronic colonisation by the micro-organism. Multivariate logistic regression analysis determined the independent effect of inhaled antibiotic treatment on the odds of chronic colonisation (OR 1.112, 95% CI [1.007-1.229], P = 0.036). Candida albicans chronic colonisation may be associated with the duration of inhaled antibiotic treatment.
Subject(s)
Anti-Bacterial Agents/administration & dosage , Candida albicans/growth & development , Cystic Fibrosis/microbiology , Respiratory System/microbiology , Sputum/microbiology , Administration, Inhalation , Adolescent , Child , Cohort Studies , Cystic Fibrosis/complications , Female , Follow-Up Studies , Health Records, Personal , Humans , Male , Multivariate Analysis , Time FactorsABSTRACT
Aspergillus fumigatus isolation in cultures from respiratory specimens of patients with cystic fibrosis (CF) is quite common; however, the role of A. fumigatus as a pathogen and whether its presence is associated with progression of pulmonary disease remain unclear. We investigated the association between inhaled corticosteroids and the recovery of A. fumigatus by performing a retrospective cohort study of CF patients born between 1988 and 1996. The patients' medical records from their first visit to the CF Center until December 2010 were reviewed. Outcomes were the occurrence of A. fumigatus first isolation, chronic colonization, or the last visit at the CF Center. A number of possible confounders were included in the multivariate logistic regression analysis in order to identify an independent association between inhaled corticosteroids and colonization status. A total of 121 patients were included in the study. Thirty-nine patients (32.2%) had at least one positive culture and 14 (11.6%) developed chronic colonization. Multivariate logistic regression analysis was used to determine the independent effect of inhaled corticosteroids on the odds of first isolation (odds ratio [OR], 1.165; 95% confidence interval [CI], 1.015-1.337; P = 0.029) and chronic colonization (OR, 1.180; 95% CI, 1.029-1.353; P = 0.018). In conclusion, A. fumigatus first isolation and chronic colonization are associated with the duration of inhaled corticosteroid treatment.
Subject(s)
Adrenal Cortex Hormones/therapeutic use , Aspergillus fumigatus/isolation & purification , Carrier State/epidemiology , Cystic Fibrosis/complications , Cystic Fibrosis/drug therapy , Immunosuppressive Agents/therapeutic use , Pulmonary Aspergillosis/epidemiology , Administration, Inhalation , Adolescent , Adrenal Cortex Hormones/adverse effects , Adult , Carrier State/microbiology , Cohort Studies , Female , Humans , Immunosuppressive Agents/adverse effects , Male , Models, Statistical , Pulmonary Aspergillosis/microbiology , Retrospective Studies , Time Factors , Young AdultSubject(s)
Anti-Bacterial Agents/therapeutic use , Foot Dermatoses/diagnosis , Foot Dermatoses/drug therapy , Fusidic Acid/therapeutic use , Gram-Positive Bacterial Infections/diagnosis , Gram-Positive Bacterial Infections/drug therapy , Adolescent , Foot Dermatoses/microbiology , Gram-Positive Bacterial Infections/microbiology , Humans , Male , Skin Diseases, Bacterial/diagnosis , Skin Diseases, Bacterial/drug therapy , Skin Diseases, Bacterial/microbiologyABSTRACT
Pasteurella multocida is usually transmitted by animal contact; however, in a significant proportion of cases, no animal exposure can be identified. Although vertical transmission has been identified in neonates, horizontal human-to-human spread has not been documented. A case of neonatal sepsis and meningitis resulting from horizontal transmission of P. multocida is described.
