[Features of pathological anatomy of COVID-19 according to autopsy results in the Volgograd Region]. / Osobennosti patologicheskoi anatomii COVID-19 po rezul'tatam autopsii v Volgogradskoi oblasti.

In connection with the ongoing pandemic of the novel coronavirus infection, the study of its morphopathology and the analysis of autopsy data are relevant. At the same time, attention should be paid to thromboses that play a significant role in the development of fatal outcomes in COVID-19, even taking into account the prescription of anticoagulant therapy to most patients. OBJECTIVE: To make an assessment of morphological changes and a statistical analysis of the structure of mortality in COVID-19 on the basis of autopsy results in the Volgograd Region in 2020. MATERIAL AND METHODS: The study was based on data from «The system for information on the work of the Volgograd Regional Autopsy Bureau¼ with a search for cases according to U07.1 code (the COVID-19 virus was identified) in January 1, 2020, to December 31, 2020, as well as on the autopsy materials of the Volgograd Regional Autopsy Bureau, and microscopic examination with photo fixation. Statistical processing was performed using the R programming language. RESULTS: During the above period, 1119 deaths were identified with a confirmed diagnosis of COVID-19. Anatomopathological examination of the autopsy material showed that 77.54% of cases had blood clots mainly in the vessels of the pulmonary microvasculature, often only in the single veins during the applied anticoagulant therapy.Analysis of variance indicated that the obtained result statistically significantly differed from the random distribution, and the probability of the presence of blood clots of specified localization was 3.17 times higher (CI 2.3-4.4; p<0.05) than their absence, as evidenced by logistic regression. In addition, perivascular and intra-alveolar diapedesis hemorrhages were noted in most fatal cases. CONCLUSION: Thus, this investigation has revealed that the high frequency of thrombosis detected in the presence of perivascular and intra-alveolar diapedesis hemorrhages in COVID-19 confirms the tendency of patients with a severe course of the disease to manifest hemostatic disorders, significant blood vascular endothelial injury, and obvious vascular impermeability.

[The results of orthodontic treatment using aligners from the perspective of quality of life of patients with dentoalveolar anomalies]. / Rezul'taty ortodonticheskogo lecheniya elainerami s pozitsii kachestva zhizni patsientov s zubochelyustnymi anomaliyami.

THE AIM OF THE STUDY WAS TO ANALYZE: The impact of morphological and functional dental components on the quality of life of adult patients undergoing orthodontic treatment using clear aligners. MATERIALS AND METHODS: Morphological and functional results of orthodontic treatment with aligners as well as the dynamics of oral health related quality of life was assessed in 55 patients aged from 20 to 25 years. RESULTS: The study of the efficacy of orthodontic treatment with aligners showed significant improvement of morphological and functional features of dental arches as well as oral health related quality of life in the course of treatment. CONCLUSION: Orthodontic treatment with aligners is efficient for achieving morphological and functional improvement and enhances social adaptation of patients by increasing oral health related quality of life.

[Assessment of prognostic factors affecting the quality of life of children with congenital cleft lip and palate]. / Otsenka prognosticheskikh faktorov, vliyayushchikh na kachestvo zhizni detei s vrozhdennoi rasshchelinoi guby i neba.

Multi-stage therapy of children with congenital diseases of the maxillofacial region requires a multidisciplinary team of specialists coordinated consistently conducted treatment, not only providing a complete reconstruction of the maxillary bones, but also improving the quality of life of children. In our study, it was found that the most significant independent predictors of the total indicator of quality of life are indicators of structures and functions of the maxillofacial region, as well as the level of activity and participation of children in real life situations and the level of parental compliance.