[Lower urinary tract symptoms in young adult men: analysis of prevalence, profile and relationship with metabolic syndrome risk factors].

AIM: To evaluate LUTS prevalence and characteristics of lower urinary tract symptoms in young men and to investigate the relationship between LUTS and metabolic syndrome risk factors. MATERIALS AND METHODS: One hundred and one male student (age between 19 and 29, mean 21,2+/-1,5 years) of St Petersburg universities (63 (62,4%) students of First State Pavlov Medical University and 38 (37,6%) students of National Research University Higher School of Economics) were anonymously questioned. Students were asked about their height, weight, metabolic syndrome risk factors and interviewed by I-PSS and QoL questionnaire. The obtained data was analyzed in order to find significant relationship. RESULTS: Lower urinary tract symptoms (I-PSS>0) were found in 84 (84%) men, mild and moderate LUTS - in 77 (77%) and 7 (7%) men, respectively. 39 (39%) men had both storage and voiding symptoms, storage only and voiding only symptoms were found in 31 (31%) and 14 (14%) students respectively. I-PSS score was higher in men with hypertension, diabetes, chronic stress and unmotivated fatigue (p=0,032, p=0,027, p=0,015 and p=0,003, respectively). In regression model (R2=0,268) I-PSS score was associated with diabetes (p<0,001), chronic stress (p=0,002) and hypertension (p=0,020). CONCLUSION: LUTS prevalence in young men is high. The relationship between LUTS and metabolic syndrome risk factors in young adult men can be considered as a reason for clinical investigation.

Prevalence and risk factors for erectile dysfunction and lower urinary tract symptoms in Russian Federation men: analysis from a national population-based multicenter study.

An analysis of prevalence and associated common risk factors of ED and lower urinary tract symptoms (LUTS) was performed in Russian Federation by cross-sectional multicenter survey. International Index of Erectile Function (IIEF) score and International Prostate Symptom Score (IPSS) were used for data collection in 1225 men between 20 and 77 years interviewed in six regions of Russian Federation. In addition, each participant's social, demographic, lifestyle, sexual and medical history was taken with special emphasis on risk factors for ED. Upon the basis of IIEF erectile domain score interpretation, ED was found in 530 (48.9%) men, consisting of mild and mild to moderate, moderate and severe ED in 375 (34.6%), 78 (7.2%) and 77 (7.1%) respondents, respectively. According to IPSS assessment, LUTSs were present in 649 (59.9%) responders; inclusive 370 (34.2%), 216 (19.9%) and 63 (5.8%) men with mild, moderate and severe LUTS, respectively. Men with both ED and LUTS shared common co-morbidities and lifestyle risk factors with age-adjusted odds ratio between 1.2 and 5.2. In logistic regression model (R(2)=0.361), the strongest associated with ED factor found was IPSS symptom score, followed by hypertension, IPSS-related quality of life, age, diabetes mellitus, obesity and unmotivated fatigue.

Characteristics of interfacial water affected by proteins adsorbed on activated carbon.

The influence of proteins (bovine serum albumin, BSA, and mouse gamma-globulin, IgG) physically adsorbed or covalently attached via coupling with N-cyclohexyl-N'-(2-morpholinoethyl) carbodiimide methyl-p-toluenesulfonate, CMC, to the surface of activated carbon SCN (spherical carbon with nitrogen) on the mobility of interfacial water molecules was studied by means of 1H NMR spectroscopy with freezing-out of bulk water at 180 < T < 273 K. Relaxation processes in the interfacial non-freezing water were investigated measuring transverse time t2 of proton relaxation dependence on the presence of proteins and CMC. The distribution function of activation free energy of relaxation (with a maximum at 20-22 kJ/mol) was calculated for the protein-water-carbon systems using a regularization procedure and the relationships between t2 and the amounts of the interfacial water unfrozen at T < 250 K assuming the Arrhenius-type dependence for t2(-1) on temperature. The state of unfrozen water in pores of SCN shows that the low temperature relaxation processes occur in narrow pores with half-width X < 1.5 nm.

On the interrelations of immune and mediator receptors of mice lymphocytes.

It was shown that the blockade of M-cholinereceptors, of B-lymphocytes in the spleen of mice of the BALB/c line immune to sheep erythrocytes, by parasympatholytics 3H-Quinuclidinyl benzilate, etc., markedly inhibits the rosette-formation with the specific antigen. The blockade of M-cholinereceptors of B-lymphocytes in the mice spleen of the given line by the anticholinereceptor rabbit serum (with removed Forsmann antibodies) induces a similar result. The specific antigen fixation on B-lymphocytes of mice immunized by egg albumin is suppressed by preliminary blockade of M-cholinereceptors by the above mentioned parasympatholytics. The number of free cholinereceptors on the surface of B-lymphocytes of mice spleen immunized with egg albumin, was reduced after the specific antigen was joined. The blockade of beta-adrenoreceptors of mice spleen evokes a similar effect but in a lesser degree. The problem of interrelation of immune and mediator lymphocyte receptors is discussed in relation with the mechanisms of nervous regulation of immune and allergic reactions.