ABSTRACT
Background: Paternal prenatal depression affects not only the fathers but also their spouses and children's future lives. Many socioeconomic and cultural factors affect the probability of paternal depression. Little is known about the prevalence of and factors associated with paternal prenatal depression in the Middle East. Aim: To estimate the prevalence of paternal prenatal depression among fathers visiting a tertiary university hospital, as well as to determine the factors associated with paternal prenatal depression within study participants. Methods: This analytical cross-sectional study included 442 fathers whose wives were pregnant and were undergoing regular assessments at antenatal clinics in a tertiary university hospital in Riyadh, Saudi Arabia. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess paternal depression. Bivariate and multivariate analyses were performed. Results: The prevalence of paternal prenatal depression was 26.9%. It was correlated with smoking (odds ratio (OR)=1.8, p=0.006), maternal depression (OR=4.59, p<0.001), and experiencing isolation (OR=5.34, p<0.001). The odds of paternal prenatal depression decreased with social support from friends and family (OR=0.227 and 0.133, respectively) and p<0.001. Discussion and Conclusion: Paternal prenatal depression was prevalent within the study participants. Notably, experiences of isolation and maternal depression emerged as prominent factors that were significantly associated with the manifestation of paternal depression. Consequently, it becomes imperative to implement systematic depression screenings for expectant fathers and to meticulously consider the array of the factors associated with paternal depression.
ABSTRACT
INTRODUCTION: In Saudi Arabia, head and neck cancers represent 6 % of all malignancies. 33 % of these are nasopharyngeal. Thus, we aimed to distinguish patterns of treatment failure and salvage treatment outcomes among patients with nasopharyngeal carcinoma (NPC). METHODS: A retrospective review of patients treated for NPC in a tertiary care hospital. From May 2012 to January 2020, we retrospectively reviewed 175 patients that fit our inclusion criteria. Those who did not complete their treatment, started treatment in another institution, or did not complete a 3-year follow-up were excluded. In addition, the primary treatment outcome and the salvage treatment for those who failed initial treatment were collected and analyzed. RESULTS: Patients were predominantly stage 4 disease. 67 % of the patients were alive without evidence of disease during their last follow-up. However, 75 % of failure occurs in the first 20 months of completing the treatment regimen. Neoadjuvant therapy and delays in referral play a significant role in treatment failure. For failed cases, concurrent salvage chemoradiotherapy showed the best survival. CONCLUSION: Advanced stage 4A and T4 nasopharyngeal carcinoma should receive the maximum treatment, with a close follow-up, particularly during the first 2 years after treatment. Furthermore, the excellent outcome from salvage chemoradiotherapy and radiotherapy alone would make physicians aware of the importance of aggressive primary treatment.
