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Int J Mol Sci
; 22(8)2021 Apr 13.
Article
in English
| MEDLINE
| ID: mdl-33924714
ABSTRACT
Oxidative stress has been postulated as an underlying pathophysiologic mechanism of diabetic retinopathy (DR), the main cause of avoidable blindness in working-aged people. This review addressed the current daily clinical practice of DR and the role of antioxidants in this practice. A systematic review of the studies on antioxidant supplementation in DR patients was presented. Fifteen studies accomplished the inclusion criteria. The analysis of these studies concluded that antioxidant supplementation has a IIB level of recommendation in adult Type 1 and Type 2 diabetes mellitus subjects without retinopathy or mild-to-moderate nonproliferative DR without diabetic macular oedema as a complementary therapy together with standard medical care.
Subject(s)
Antioxidants/administration & dosage , Antioxidants/therapeutic use , Diabetic Retinopathy/drug therapy , Dietary Supplements , Administration, Oral , Diabetic Retinopathy/diagnosis , Diabetic Retinopathy/epidemiology , Diabetic Retinopathy/physiopathology , Humans , Risk Factors
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