Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters











Database
Language
Publication year range
1.
Virology ; 419(1): 24-42, 2011 Oct 10.
Article in English | MEDLINE | ID: mdl-21868050

ABSTRACT

The human apolipoprotein B mRNA editing enzyme catalytic peptide-like 3 (APOBEC3; A3) family of proteins (A3A-H) are known to restrict various retroviruses and retroelements, but the full complement of rhesus macaque A3 proteins remains unclear. We report the isolation and characterization of the hA3A homologue from rhesus macaques (rhA3A) and show that the rhesus macaque and human A3 genes are orthologous. RhA3A is expressed at high levels in activated CD4+ T cells, is widely expressed in macaque tissues, and is degraded in the presence of the human immunodeficiency virus (HIV-1) and simian-human immunodeficiency virus (SHIV) genomes. Our results indicate that rhA3A is a potent inhibitor of SHIVΔvif and to a lesser extent HIV-1Δvif. Unlike hA3A, rhA3A did not inhibit adeno-associated virus 2 (AAV-2) replication and L1 retrotransposition. These data suggest an evolutionary switch in primate A3A virus specificity and provide the first evidence that a primate A3A can inhibit lentivirus replication.


Subject(s)
Cytidine Deaminase/immunology , Cytidine Deaminase/metabolism , Evolution, Molecular , Macaca mulatta/virology , Simian Immunodeficiency Virus/immunology , APOBEC-1 Deaminase , Animals , CD4-Positive T-Lymphocytes/enzymology , Dependovirus/immunology , Gene Expression Profiling , HIV/immunology , Humans , Molecular Sequence Data , Retroelements/immunology , Sequence Analysis, DNA , Sequence Homology, Amino Acid
SELECTION OF CITATIONS
SEARCH DETAIL