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J Am Acad Dermatol ; 74(2): 197-212, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26775771

ABSTRACT

Few sources of information exist regarding cutaneous innervation and how to apply this basic neurologic science to the clinical treatment of itch, as often performed on a daily basis by dermatologists. We address the types of nerve fibers that innervate the skin and their different components and discuss the similarities and differences between itch and pain. We hope that increased knowledge of this topic will improve the recognition and treatment of neuropathic itch.


Subject(s)
Pain/metabolism , Pruritus/drug therapy , Pruritus/metabolism , Skin/innervation , Skin/metabolism , Analgesics, Opioid/metabolism , Animals , Calcineurin/metabolism , Histamine/metabolism , Humans , Neural Pathways , Peptide Hydrolases/metabolism , Signal Transduction , Skin Physiological Phenomena , TRPV Cation Channels/metabolism
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