ABSTRACT
BACKGROUND: Blood transfusion is common during the peri-transplantation period. The incidence of immunological reactions to blood transfusion after kidney tran splantation and their consequences on graft outcomes have not been extensively studied. AIM: To examine the risk of graft rejection and loss in patients who received blood transfusion in the immediate peri-transplantation period. METHODS: We conducted a single-center retrospective cohort study of 105 kidney recipients, among them 54 patients received leukodepleted blood transfusion at our center between January 2017 and March 2020. RESULTS: This study included 105 kidney recipients, of which 80% kidneys were from living-related donors, 14% from living-unrelated donors, and 6% from deceased donors. Living-related donors were mostly first-degree relatives (74.5%), while the rest were second-degree relatives. The patients were divided into transfusion (n = 54) and non-transfusion (n = 51) groups. The average hemoglobin level at which blood transfusion was commenced was 7.4 ± 0.9 mg/dL. There were no differences between the groups in terms of rejection rates, graft loss, or death. During the study period, there was no significant difference in creatinine level progression between the two groups. Delayed graft function was higher in the transfusion group; however, this finding was not statistically significant. A high number of transfused packed red blood cells was significantly associated with increased creatinine levels at the end of the study. CONCLUSION: Leukodepleted blood transfusion was not associated with a higher risk of rejection, graft loss, or death in kidney transplant recipients.
ABSTRACT
OBJECTIVES: To determine the prevalence and patterns of antibiotic resistance, risk factors, and appropriate empiric therapy for multidrug-resistant Enterococcus (MDRE) urinary tract infections (UTIs) at King Abdulaziz Specialist Hospital (KAASH), Taif, Saudi Arabia. METHODS: All patients attending KAASH with MDRE UTIs between January 2018 and December 2020 were enrolled in the study. After ethical approval, data were analyzed. RESULTS: The most common causative organisms were Gram-negative and anaerobes, and the most sensitive antibiotics were ciprofloxacin and ceftriaxone. CONCLUSION: Based on our analyses, regular culture and sensitivity should be made routine to gather information regarding susceptibility patterns, thereby reducing drug resistance in our setups.
Subject(s)
Urinary Tract Infections , Hospitals , Humans , Prevalence , Retrospective Studies , Saudi Arabia/epidemiology , Urinary Tract Infections/drug therapy , Urinary Tract Infections/epidemiologyABSTRACT
Background: Venous thromboembolism (VTE) contains deep vein thrombosis (DVT) and pulmonary embolism (PE). It is a disabling circumstance with a high probability of recurrence and doubtlessly deadly. VTE is a significant public health issue affecting thousands of patients globally and is accountable for a high number of hospitalizations annually. Methods: A total of 1661 Saudis were surveyed in a cross-sectional observational study. A questionnaire that has already been designed was used to gather information about sociodemographic characters, knowledge about DVT, risk factors, symptoms, complications, relation to patient's activity, the seriousness of DVT leading to death, and symptoms of PE. Result: Approximately 45.5% among participants had prior awareness of DVT. Overweight and long-term travel was the most well-known risk factors. Most of the participants (60%) were aware that DVT occurs when a patient spends most of their time in bed relaxing, the most frequent clinical manifestations were pain and discomfort (97.8%) and local leg pain (73.8%). 45.3% of the participants knew DVT can result in mortality, 36.4% knew more than one pulmonary embolism characteristic, 35%, and 12.6% were aware that post-coagulation syndrome and pulmonary embolism are problems. 12% had a better understanding of DVT and 79% had poor knowledge. Participants who were above 66 years had a university degree, worked in a health specialty, knew about DVT, and received such information from their studies as medical students had a much higher mean knowledge score on DVT than others. Conclusion: Poor knowledge necessitates community education programs about risk factors, signs and symptoms, and sequelae of DVT.
