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Neurology ; 68(24): 2129-31, 2007 Jun 12.
Article in English | MEDLINE | ID: mdl-17562834

ABSTRACT

Collateral circulation influences cerebral infarction occurrence and size. Statins may improve ischemic stroke outcomes. We evaluated the relationship between prestroke statin use and pretreatment angiographic collateral grade among acute ischemic stroke patients presenting with occlusion of a major cerebral artery. After adjusting for covariates, the statin-treated group had significantly higher collateral scores than non-statin users, suggesting an association between statin use and better collateralization during acute stroke.


Subject(s)
Brain Ischemia/drug therapy , Cerebral Arteries/drug effects , Collateral Circulation/drug effects , Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology , Microcirculation/drug effects , Stroke/drug therapy , Age Factors , Aged , Aged, 80 and over , Blood Pressure/drug effects , Blood Pressure/physiology , Brain Ischemia/physiopathology , Cerebral Arteries/physiopathology , Cerebrovascular Circulation/drug effects , Cerebrovascular Circulation/physiology , Female , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Hypertension/complications , Hypertension/physiopathology , Male , Microcirculation/physiopathology , Middle Aged , Prospective Studies , Recovery of Function/drug effects , Recovery of Function/physiology , Retrospective Studies , Stroke/physiopathology , Treatment Outcome
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