ABSTRACT
This article reviews the recent dermatopathology literature regarding cutaneous adnexal neoplasms, with emphasis on new and underrecognized entities, "old entities" with new findings, advances in immunohistochemistry, and new findings in relation to inherited disorders associated with cutaneous adnexal neoplasms.
Subject(s)
Neoplasms, Adnexal and Skin Appendage/pathology , Neoplastic Syndromes, Hereditary/pathology , Biomarkers, Tumor/analysis , Biomarkers, Tumor/genetics , Biopsy , Dermatology/methods , Genetic Predisposition to Disease , Humans , Immunohistochemistry , Neoplasms, Adnexal and Skin Appendage/chemistry , Neoplasms, Adnexal and Skin Appendage/genetics , Neoplastic Syndromes, Hereditary/genetics , Neoplastic Syndromes, Hereditary/metabolism , Pathology/methods , Phenotype , Predictive Value of Tests , PrognosisABSTRACT
The "acid mantle" is a topic not only of historical interest, but also of clinical significance and has recently been linked to vital stratum corneum function. Despite compelling basic science evidence placing skin pH as a key factor in barrier homeostasis, stratum corneum integrity, and antimicrobial defense, application of the acid mantle concept in clinical care is lacking. We review recent basic science investigations into skin pH, discuss skin disorders characterized by aberrant pH, and finally discuss practical application for preservation of the acid mantle. Recognizing factors that alter skin pH and selecting products that preserve the acid mantle is of prime importance in treating dermatologic patients.
Subject(s)
Skin Care , Skin Diseases/metabolism , Skin/metabolism , Translational Research, Biomedical , Animals , Homeostasis , Humans , Hydrogen-Ion Concentration , Skin/pathology , Skin Care/methods , Skin Diseases/pathologySubject(s)
Dermatitis, Atopic/pathology , Ear, External/pathology , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Infant , Male , Middle Aged , Severity of Illness Index , Young AdultABSTRACT
BACKGROUND: Sarcoidosis is a systemic disease that may present as tattoo granulomas. OBJECTIVE: A patient with systemic sarcoidosis who developed a granulomatous reaction within a tattoo is presented to stimulate interest in this unusual phenomenon. METHODS AND RESULTS: A patient with a 6-year history of pulmonary sarcoidosis developed sarcoidal granulomas restricted to one pigment of a tattoo. Previous reports of sarcoidal granulomas within tattoos are reviewed, and information about the pathogenesis of this process is explored. CONCLUSION: Sarcoid granulomas may develop in tattoos as an isolated local reaction or as the presenting sign of systemic sarcoidosis. The reaction itself may provide insight into further understanding the pathogenesis of sarcoidosis.
Subject(s)
Sarcoidosis/diagnosis , Sarcoidosis/etiology , Skin Diseases/diagnosis , Skin Diseases/etiology , Tattooing/adverse effects , Abdomen , Adult , Coloring Agents/adverse effects , Diagnosis, Differential , Female , Humans , Sarcoidosis/pathology , Skin Diseases/pathologySubject(s)
Immunologic Factors/therapeutic use , PUVA Therapy , Psoriasis/drug therapy , Treatment Refusal , Dermatology , HumansABSTRACT
In a linguistically diverse society, healthcare professionals must overcome the daunting task of effectively communicating with patients who speak a different language. In effort to aid healthcare professionals and their patients, an on-line dermatology patient education resource was created with links to various skin related topics in over 30 languages. The development of the on-line resource, key features of the information available on the website, and limitations experienced during its creation are discussed in the article.
