1.
Chem Commun (Camb)
; 57(94): 12667-12670, 2021 Nov 25.
Article
in English
| MEDLINE
| ID: mdl-34778897
ABSTRACT
We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8+ T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.