Fabrication of electrospun poly(vinyl alcohol)/dextran nanofibers via emulsion process as drug delivery system: Kinetics and in vitro release study.

A green electrospinning was used for the fabrication of PVA/Dex (dextran sulfate) nanofibers as a carrier for drug delivery. Core-shell nanofibers were fabricated by emulsion electrospinning from PVA/Dex loaded with ciprofloxacin (Cipro) as a model drug. The ratio of the PVA/Dex mixture was optimized and nanofibers were stabilized against disintegration in water by thermal treatment at 120 °C. The morphology of the prepared nanofibers was observed by scanning electron microscopy (SEM) and the core-shell structure of the nanofibers was confirmed by transmission electron microscopy (TEM). Drug entrapment was confirmed by Fourier-transform infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA). The interaction between PVA and Dex was affirmed by differential scanning calorimetry (DSC). In vitro drug release was monitored by UV-vis spectrophotometer and its associated mechanism was studied using diverse kinetic models. The release study demonstrated that the core-shell nanofibers can sustain the Cipro release compared with the blending electrospinning nanofibers. Moreover, the drug release mechanism is controlled by the Dex content of the polymer blends and can occur by diffusion within the delivery system. It is anticipated that Cipro@PVA/Dex nanofibers are promising eco-friendly drug delivery system which can be prepared by a green method.

Synthesis and spectral characterization of hydrazone derivative of furfural using experimental and DFT methods.

The Spectral Characterization of (E)-1-(Furan-2-yl) methylene)-2-(1-phenylvinyl) hydrazine (FMPVH) were carried out by using FT-IR, FT-Raman and UV-Vis., Spectrometry. The B3LYP/6-311++G(d,p) level of optimization has been performed on the title compound. The conformational analysis was performed for this molecule, in which the cis and trans conformers were studied for spectral characterization. The recorded spectral results were compared with calculated results. The optimized bond parameters of FMPVH molecule was compared with X-ray diffraction data of related molecule. To study the intra-molecular charge transfers within the molecule the Lewis (bonding) and Non-Lewis (anti-bonding) structural calculation was performed. The Non-linear optical behavior of the title compound was measured using first order hyperpolarizability calculation. The atomic charges were calculated and analyzed.