ABSTRACT
No disponible
Subject(s)
Male , Middle Aged , Humans , Fournier Gangrene/diagnosis , Genitalia, Male/microbiology , Fournier Gangrene/therapy , Anti-Bacterial Agents/therapeutic useABSTRACT
El bupropion es un antidepresivo poco utilizado en nuestro país, cuyo uso ha sido recientemente aprobado para su uso en la deshabituación tabáquica. Presentamos el caso de una paciente de 41 años que desarrolló un exantema causado por bupropion. Se han descrito diversos efectos secundarios cutáneos de este fármaco que probablemente comencemos a ver en nuestro país tras su comercialización (AU)
Subject(s)
Bupropion/toxicity , Tobacco Use Disorder/therapyABSTRACT
No disponible
Subject(s)
Adolescent , Male , Humans , Skin Diseases , Pancytopenia , Dyskeratosis Congenita , Lacrimal Duct ObstructionABSTRACT
No disponible
Subject(s)
Adolescent , Female , Male , Child , Humans , Vitiligo/therapy , Melanocytes/pathology , Catalase/therapeutic use , Phototherapy/methods , Phototherapy , Evidence-Based Medicine/methods , Skin Diseases/therapy , Adrenal Cortex Hormones/therapeutic use , Transplantation, Autologous , Phototherapy/trends , Skin Diseases/drug therapy , Skin Diseases/pathologySubject(s)
Pigmentation Disorders/diagnosis , Adult , Biopsy , Bone and Bones/diagnostic imaging , Female , Forearm , Histiocytoma, Benign Fibrous/complications , Histiocytoma, Benign Fibrous/diagnosis , Humans , Osteopoikilosis/complications , Osteopoikilosis/diagnosis , Pigmentation Disorders/etiology , Radiography , Skin/pathology , Skin Neoplasms/complications , Skin Neoplasms/diagnosis , SyndromeABSTRACT
Tinea incognito represents a new entity caused basically by the careless application of corticosteroidal creams. We present a 71-year-old man with disseminated erythematous and squamous lesions treated with corticosteroid creams for seven months; the clinical aspect worsened and new pustular lesions appeared. The diagnosis of disseminated inflammatory tinea was confirmed by culture, with the growth of Trichophyton mentagrophytes. We comment on the clinical findings and the factors that contribute to spread the process.
ABSTRACT
Rothmund-Thomson syndrome is a rare autosomal recessive genodermatosis characterised by poikilodermatous skin changes that appear in childhood. Patients exhibit variable additional features including juvenile cataracts, skeletal abnormalities and a higher than expected incidence of malignancies. We report a case of squamous cell carcinoma of the tongue in a 37-year-old Rothmund-Thomson syndrome patient and review the natural history of this rare disease, given that the patient was diagnosed with Rothmund-Thomson syndrome at the age of 8 years and was first reported in 1975.
Subject(s)
Carcinoma, Squamous Cell/etiology , Rothmund-Thomson Syndrome/complications , Tongue Neoplasms/etiology , Adult , Carcinoma, Squamous Cell/pathology , Follow-Up Studies , Humans , Male , Tongue Neoplasms/pathologyABSTRACT
Ossifying fibromyxoid tumors (OFT) of soft parts are very rare neoplasms recently described by Enzinger et al. (1). They usually present as well-circumscribed, slow-growing, asymptomatic subcutaneous masses. A characteristic finding is a fibrous capsule and an incomplete peripheral shell of mature bone. Although most cases behave as benign tumors, a high rate of local recurrences have been described. We describe a 43-year-old male with a perianal subcutaneous tumor of 10 years evolution. The histopathology was compatible with OFT. Due to the subcutaneous location of OFT, both the dermatologist and dermatopathologist need to know about this rare tumor.
Subject(s)
Fibroma/pathology , Ossification, Heterotopic/pathology , Skin Neoplasms/pathology , Soft Tissue Neoplasms/pathology , Adult , Humans , MaleSubject(s)
Necrobiosis Lipoidica/pathology , Penile Diseases/pathology , Humans , Male , Middle Aged , Ulcer/pathologyABSTRACT
Skin involvement in non-Hodgkin lymphoma is usually specific and may precede systemic manifestations of the disease by months or even years. We report the case of a man with an inguinal plaque lesion of 1 year's evolution, diagnosed as polymorphous lymphoplasmocytoid lymphoma (immunocytoma). The evaluation of spread only revealed mesenteric lipodystrophy, whose association with lymphoid processes is more common than would be expected.
Subject(s)
Leukemia, Lymphocytic, Chronic, B-Cell/complications , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Lipodystrophy/complications , Lipodystrophy/pathology , Mesentery/pathology , Skin Neoplasms/complications , Skin Neoplasms/pathology , Aged , Humans , Lymphoma, Non-Hodgkin/pathology , Male , Peritoneal Diseases/complications , Peritoneal Diseases/pathologyABSTRACT
BACKGROUND: Since the recent description of immediate hypersensitivity to latex, many cases have been reported, some of them with anaphylactic reactions. The aim of this study is to analyze the clinical findings, diagnostic management and therapeutic procedures in these patients. METHODS: We reviewed the clinical findings in 15 patients with contact urticaria to latex from our files. Use-test with a surgical glove, prick-test trough a rubber glove, RAST to latex and standard patch-tests were performed in each case. RESULTS: We found a M:F ratio of 1:4 (3 males and 12 females) and the mean age at diagnosis was 33 years. Atopic background was present in 60% of cases and 46% were health care workers. Systemic manifestations of allergy were found in 25% of patients. Two cases developed anaphylactic shock. Cutaneous manifestations included localized contact urticaria in 33% of cases, chronic hand eczema and urticaria in 46%, and immediate contact dermatitis in 20%. All cases showed a positive use-test, while prick-test and RAST showed positive results in only 75% of patients. Positive patch-test to rubber accelerators were found in 33% of cases. CONCLUSIONS: Latex immediate hypersensitivity is frequently seen at present. Its prevalence in health care workers is high. Atopic constitution, chronic hand eczema, continuous gloves usage, and contact dermatitis to rubber additives are predisposing factors. Diagnosis can be assessed by clinical findings and use-test, confirming by prick-test and RAST.
Subject(s)
Anaphylaxis/chemically induced , Latex/adverse effects , Urticaria/chemically induced , Adolescent , Adult , Anaphylaxis/diagnosis , Anaphylaxis/epidemiology , Disease Susceptibility , Female , Humans , Male , Middle Aged , Risk Factors , Skin Tests/methods , Spain/epidemiology , Urticaria/diagnosis , Urticaria/epidemiologyABSTRACT
A HIV infected patient was admitted to hospital with fever diarrhoea and a cutaneous nodule on his left groin. Histopathological exam was diagnostic of cutaneous leishmaniasis. Subsequent exams disclosed Visceral Leishmaniasis. Three cycles of treatment (antimonials, pentamidine and metronidazole) were required for the clearance of lesions. The relation between immunosuppression and leishmania infection is commented and its role as an opportunistic pathogen is suggested. In these patients the infection takes a more aggressive course and has a worse response to the classic treatment with antimonials. These facts have made necessary the introduction of other alternative drugs.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Leishmaniasis, Mucocutaneous/complications , Leishmaniasis, Visceral/complications , Opportunistic Infections/complications , Adult , Humans , Leishmaniasis, Mucocutaneous/pathology , Leishmaniasis, Visceral/pathology , Male , Opportunistic Infections/pathologyABSTRACT
We present a case of subungueal keratoacanthoma. The tumor recurred three months after extirpation and didn't resolve spontaneously. The patient need a new surgery a year later. We revised the literature and comment the clinical and histological features that define this distinct entity and differentiate it from common keratoacanthoma and subungueal squamous cell carcinoma.
Subject(s)
Keratoacanthoma/pathology , Nail Diseases/pathology , Adult , Humans , MaleABSTRACT
We have carried out retrospective study of 190 children with dermatitis, aged from 2 to 14 years old. 67 (35%) of these children showed positive patch-test reactions. Nickel sulphate (35%) was the first allergen. Form 1979, once mercury was introduced in the GEIDC standard series, it becomes the more common iatrogenic allergen in childhood in our country. Other allergens also responsible for the dermatitis were mercaptobenzothiazole (12%), cobalt (9%) and p-phenylenediamine (7%).
Subject(s)
Dermatitis, Contact/epidemiology , Adolescent , Child , Child, Preschool , Dermatitis, Contact/diagnosis , Female , Humans , Male , Retrospective Studies , Skin TestsABSTRACT
We present a 45 years old male with dermatomyositis refractory to eight months of standard treatment who responded to plasma exchange. The efficacy of the procedure is estimated from clinical follow-up (increase in strength) and serum creatine-kinase activity (decrease from 3,380 to 44 u/ml.) after five sessions of plasma exchange. The therapeutic indications for PE are reviewed in dermatological diseases with emphasis on cases where the response to steroids or cytotoxic drugs is inadequate.
Subject(s)
Dermatomyositis/therapy , Plasma Exchange , Dermatomyositis/blood , Humans , Male , Middle AgedABSTRACT
A case of a woman of 23 years old with lesions in the exposed areas of the skin (face and lower neck) is presented. The histological study was compatible with pemphigus (subcorneal acantholysis and acantholytic cells). The direct immunofluorescence revealed the presence of IgG in intercellular spaces on all the surfaces of the epidermis. In the indirect immunofluorescence ANA (1/800), anti-DNA (1/200) and anti-ICS (1/200) was found. The rest of the analysis clearly showed thrombocytopenia and C4 consumption. The interesting aspect of this case rests in the coexistence of clinical and analytical findings of each of these of autoimmune diseases.
Subject(s)
Autoimmune Diseases/immunology , Lupus Erythematosus, Systemic/complications , Pemphigus/complications , Adult , Antibodies, Antinuclear/analysis , Female , Fluorescent Antibody Technique , Humans , Immunoglobulin G/analysis , Lupus Erythematosus, Systemic/immunology , Pemphigus/immunology , Thrombocytopenia/complicationsABSTRACT
During the summer months three young patients were examined by us for an asymptomatic cutaneous eruption of erythematous papules located on neck, shoulders and back. They were heat-resistant to several antiseptics and systemic antibiotic treatment. The mechanical expression of these lesions did not reveal the appearance of pus, but a hard keratinous matter. The histopathological findings of the lesions show a non specific folliculitis, but the PAS stain shows numerous spores of yeast forms within the keratinous material of the follicle. The culture of this material in bacteriological and mycological ordinary media is negative, but the culture in the Dixon media reveals the growth of typical colonies of Pityrosporum orbiculare. The patients responded successfully to a 3 weeks course of ketoconazole (200 mgr/d).
