1.
Eksp Klin Farmakol
; 69(3): 35-9, 2006.
Article
in Russian
| MEDLINE
| ID: mdl-16878497
ABSTRACT
Intramuscular injection of an oil solution of tefestrol, as well as the oral administration of tefestrol tablets and the parenteral administration of sinestron in doses of 0.01, 0.1, 1, and 5 mg/kg led to a pronounced estrogen effect in both nonpubertate and pubertate (intact and ovariectomized) rats. In the minimum dose, the estrogen activity of the injection preparation exceeded that of tablets. Preliminary tefestrol injections accelerated the fertilization and pregnancy. The injection form has a shorter latent period and produces a longer estrogen effect, while not violating fetus implantation, producing no toxic action, and having no negative influence on the pregnancy terms and the development of fetus.
Subject(s)
Embryo Implantation/drug effects , Fertilization/drug effects , Plant Extracts/pharmacology , Administration, Oral , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Female , Pregnancy/drug effects , Rats , Sexual Maturation/drug effects
2.
Akush Ginekol (Mosk)
; (5): 48-51, 1983 May.
Article
in Russian
| MEDLINE
| ID: mdl-6614355