ABSTRACT
In spite of the availability of many antituberculosis drugs all over the world the morbidity of tuberculosis does not lower. Often the tuberculosis therapy schemes are adapted to every particular patient which is mainly due to the therapy unfavourable effects requiring discontinuation of the drugs used. Polymorphism of the detoxication genes, as predictors of the response to the drug therapy, was shown to be of certain significance. The experimental data would allow to substantiate personalized management of tuberculosis patients and to increase its efficacy and safety.
Subject(s)
Antitubercular Agents/therapeutic use , Arylamine N-Acetyltransferase/genetics , Cytochrome P-450 CYP2C9/genetics , Cytochrome P-450 CYP2E1/genetics , Precision Medicine/methods , Tuberculosis, Pulmonary/drug therapy , Adult , Algorithms , Antitubercular Agents/adverse effects , Antitubercular Agents/pharmacokinetics , Female , Humans , Male , Medical Records , Middle Aged , Polymorphism, Genetic , Tuberculosis, Pulmonary/genetics , Young AdultSubject(s)
Lacrimal Apparatus/anatomy & histology , Adolescent , Adult , Female , Fluoresceins , Humans , Lacrimal Apparatus/physiology , Male , Middle Aged , Reference Values , Time FactorsSubject(s)
Lacrimal Apparatus/physiopathology , Silver Compounds , Silver , Adolescent , Adult , Female , Humans , Male , Middle Aged , Reference ValuesSubject(s)
Diabetes Mellitus/metabolism , Eye/metabolism , Glutathione Peroxidase/metabolism , Selenium/analysis , Aged , Humans , Middle AgedSubject(s)
Glaucoma/epidemiology , Mass Screening/methods , Adult , Evaluation Studies as Topic , Female , Humans , Intraocular Pressure , Male , Middle Aged , USSRSubject(s)
Conjunctiva/metabolism , Lacrimal Apparatus Diseases/diagnosis , Lacrimal Apparatus/metabolism , Silver Compounds , Tears/metabolism , Absorption , Adolescent , Adult , Female , Humans , Male , Middle Aged , Silver , Time FactorsABSTRACT
In order to define more accurately normal dimensions and form of the lacrimal point as well as peculiarities in the structure of the vertical part of the lacrimal canaliculus, 315 practically healthy persons (630 eyes) at the age of 18-60 years have been examined. The procedure has been performed by means of the slit lamp (shchl-1) . The lacrimal point has been found to have a round (36.1%) and an oval (63.9%) form. Transition of the lacrimal point into the vertical part of the lacrimal canaliculus in 83.5% of the observations is "fannel"-shaped with a maximal narrowing at the depth of 0.4-0.5 mm, and in 16.5%-- well"-shaped (without any narrowing). The normal diameter of the lacrimal point is 0.2-0.6 mm (the arithmetic mean-- 0.35 mm). When the diameter of the lacrimal point is less than 0.2 mm (at least in one of its sections), the lacrimation function correspondingly deteriorates, indices of the coloured nasolacrimal test become decreased or negative.
