ABSTRACT
OBJECTIVE: Benign and malignant lesions of the breast may have similar appearances on fine-needle aspiration cytology. We report a case of fibroadenoma that was diagnosed as carcinoma by cytology. CASE STUDY: Breast fine-needle aspiration biopsy was highly cellular and composed of bland-appearing spindle/columnar cells that could represent either epithelial or stromal cells; the case was reported as positive and the patient had subsequent excisional biopsy taken. RESULTS: On microscopic examination, smears were hypercellular and had many single cells and clusters of columnar/ elongate cells No obvious bipolar cells of myoepithelial origin were seen. Significant atypia was noted. Immunocytochemistry for smooth muscle actin was not performed due to insufficient material. CONCLUSIONS: Some cases of fibroadenoma and carcinoma can be very difficult to distinguish on fine needle aspiration cytology smears. Immunocytochemistry may be of help if sufficient material is provided. To avoid false positive diagnosis on cytology, it is best to report such a case as intermediate (atypical/suspicious) with final interpretation pending excisional biopsy.
Subject(s)
Biopsy, Fine-Needle , Breast Neoplasms/pathology , Carcinoma/pathology , Fibroadenoma/pathology , Breast Neoplasms/diagnosis , Carcinoma/diagnosis , Diagnosis, Differential , Female , Fibroadenoma/diagnosis , Humans , Sensitivity and SpecificitySubject(s)
Carcinoma, Papillary/complications , Hyperparathyroidism/complications , Thyroid Neoplasms/complications , Uremia/complications , Adult , Aged , Carcinoma, Papillary/epidemiology , Female , Humans , Hyperparathyroidism/epidemiology , Male , Middle Aged , Prevalence , Retrospective Studies , Thyroid Neoplasms/epidemiology , Uremia/epidemiologyABSTRACT
BACKGROUND: Poland's syndrome, a rare congenital anomaly characterized by a defect of the pectoralis muscles, has been reported in association with lymphoreticular malignancies and some solid tumors. CASE REPORT: We report the case of a 53-year-old woman with Poland's syndrome who developed breast cancer in the afflicted ipsilateral hypoplastic breast. FNA cytology revealed a moderately differentiated carcinoma and histology was consistent with a well differentiated invasive ductal carcinoma. CONCLUSION: Poland's syndrome can be associated with breast cancer so all females with the syndrome should be thoroughly examined for early detection of neoplasia.
Subject(s)
Breast Neoplasms/pathology , Carcinoma, Ductal/pathology , Poland Syndrome/pathology , Female , HumansABSTRACT
Ventriculoperitoneal shunting (VPS) is the standard treatment of hydrocephalus in children but can be followed by various intraabdominal complications. Formation of a cerebrospinal fluid (CSF) pseudocyst is a rare VPS complication. A case of a non-infected CSF pseudocyst complicated with acute appendicitis is presented.
