Prostatic tumours among Nigerian males: a private practice experience in Benin-City, South-South, Nigeria.

AIMS AND OBJECTIVES: To highlight the frequency and histological types of prostatic tumours seen in a private practice setting in Benin-City, South-South Nigeria. MATERIALS AND METHODS: Haematoxylin and eosin stained-slides of prostatic biopsies diagnosed at the Ashamas Foundation Diagnostic Centre, Benin-City for 10 years were archived and studied. Histological request forms were analysed for clinical bio-data, type of biopsies and diagnosis. RESULTS: A total of 908 prostatic tumours comprising of 468 open prostatectomies, 378 transurethral prostatectomies, 60 needle biopsies and 2 unspecified biopsy types were diagnosed. The peak age incidence of prostatic tumours was 60-69 years accounting for 37% of all prostatic tumours. Nodular prostatic hyperplasia (NPH) was the most common tumour accounting for 74.9%. Prostatic cancer was the second most common tumour accounting for 22.1% of all prostatic tumours. Six cases (1.3%) of incidental carcinoma were diagnosed out of the 680 cases of NPH. Transitional cell carcinoma and metastatic carcinoma constituted 0.2%, 0.1% of prostatic tumours respectively. In all, carcinosarcoma and fibrosarcoma accounted for 0.1% each of the prostatic tumours. High grade prostatic intraepithelial neoplasm accounted for 0.2% while 1.1% was inadequate for histopathological diagnosis. CONCLUSION: Nodular prostatic hyperplasia accounted for vast majority of all prostatic tumours in this study. However a significant percentage of prostatic adenocarcinoma was also encountered. Health education and population based screening modalities are advocated to reduce prostatic tumour morbidity and mortality in the Nigerian adult male population.

A review of 61 cases of ocular tumours seen over a 3-year period in Benin City, Nigeria: a 3-year descriptive retrospective study (1998-2000).

The aim of this study is to ascertain the tumour type, sex variation and mean age of presentation of ocular tumours, as well as to update the available literature on the prevalence of the common ocular neoplasms in our environment. In this study, we analysed the data of 61 ocular biopsy specimens received between January 1998 and December 2000 at the Morbid Anatomy Department of the University of Benin Teaching Hospital, Benin City, Nigeria. Slides from paraffin embedded blocks of all ocular biopsies received were reviewed to identify the tumour types, sex variation and age of presentation.

Presentation of Colorectal Cancers in Benin-City; Nigeria

Background: Colorectal cancer is a major cause of cancer death worldwide; and the prevalence in Nigeria appears to be increasing due to a shift to western diets. We undertook a retrospective analysis of colorectal cancers seen at the University of Benin Teaching Hospital; Benin City from January 1983 to December 2002. Methods: One hundred and two cases involving the large bowel were encountered. These were analysed for age; sex; site; histological type and clinical features. Results: The mean age was 44.5 +/-4.5 years. Males accounted for 56 (54.9) cases; while 46(45.1) were females. Seventy two (70.2) of the tumours were located in the rectum. Adenocarcinoma was the predominant histological type; with 89 (87.2) cases. Fifty two (51) cases presented with intestinal obstruction. Conclusions: Conclusion; colorectal cancers are not rare in our environment as previously believed; though; the frequency in Benin City is relatively low

Benign childhood tumours in Benin City, Nigeria.

A retrospective analysis of benign tumours seen in children aged 0-14 years over a 10-year period (1993-2002) was carried out in Benin City Nigeria, in order to determine the various histological types of such tumours. A total of 76 cases were seen during the study period, out of which 32 occurred in males and 44 in females. The commonest histological categories were tumours of connective tissues, peripheral nerve and teratoma. Haemangioma and neurofibroma occurred with equal frequency and were the single most common histological types of benign childhood tumours. Head and neck was the most common anatomic region to be involved with childhood benign tumours.

Malignant childhood solid tumours in Benin City, Nigeria.

BACKGROUND: Tumours are uncommon in childhood; malignancies are even more uncommon. Yet malignancies are among the leading causes of childhood death in many parts of the world. The pattern of these tumours in Benin City Nigeria, however, is not known. OBJECTIVE: To describe the pattern and histological types of childhood tumours in a Nigerian teaching hospital. METHODS: All histologically diagnosed cases of malignant solid tumours in children less than 15 years of age seen over a 10 year at the University of Benin Teaching Hospital (UBTH) Benin City of southern Nigeria were analysed in order to determine their histological patterns. RESULTS: Eighty-four cases of malignant tumours were seen during the 10-year period (1993 to 2002) in children less than 15 years of age at the UBTH Benin City. Forty-nine (50.3%) cases occurred in males and 35 (41.7%) in females. There was a decline in the frequency of childhood cancer with increasing age. The histological types, in descending order of frequency, were lymphoma 28(33.3%), nephroblastoma 18 (21.4%), retinoblastoma, rhabdomyosarcoma 12 (14.3%) each, and carcinoma 9 (10.7%). The head and neck region was the commonest location for all the various histological types (except tumours arising from tissues specific to other regions e.g. nephroblastoma). About 40% of all tumours occurred in the head and neck compared to 32% that occurred in the abdomen. CONCLUSION: Malignant childhood solid tumour pattern in Benin City Nigeria is similar to that observed in other third world countries.

Morbidity and mortality among road users in Benin-City, Nigeria.

BACKGROUND/OBJECTIVE: Murray and Krug had reported that road traffic injuries are a major cause of death globally, with disproportionate number occurring in developing counties. Seventy out of 308 deaths that occurred in Benin City from August 2002-July 2003, representing 22.7% of all deaths was due to road traffic injuries. Despite this observation, there is a paucity of data on road traffic morbidity and mortality. The aim of this study was to evaluate patterns of morbidity and mortality among drivers and passengers of cars involved in road traffic accidents in Benin-City Nigeria from August 2002-July 2003 as a base line data. METHODS: Eighty-seven car drivers and passengers who were studied were part of a larger study, involved in a road traffic accident and brought to the accident and emergency units of either the University of Benin Teaching Hospital or the State Specialist Hospital between August 2002-July 2003.The injured ones were examined and dead patients had autopsy done on them. RESULTS: Over all, out of 283 total accidents cases reviewed in the period of study 87 were car occupants representing 30.7% of all accident cases, and 67 patients (23.7%) sustained varying injuries, while 20 patients (7.1%) died. Commercial cars were involved in majority of cases 85%. Males were also more in number. Intracranial hemorrhage was the predominant cause of death. CONCLUSION: Occupants of cars accounted for the singular most common category of morbidity and mortality among all road users. The male to female ratio was 2.1:1. Windscreen injuries most commonly associated with facial and head injuries represented the commonest cause of morbidity and mortality. The commonest autopsy finding as cause of death was intra-cranial hemorrhage.

Patterns of morbidity and mortality amongst motorcycle riders and their passengers in Benin-City Nigeria: one-year review.

OBJECTIVE: To evaluate patterns of morbidity and mortality among bike riders and pillion seat passengers involved in road traffic accidents in Benin-City Nigeria between August 2003-July 2004. METHODS: A total of Fifty-one bike riders and pillion seat passengers, who participated in this study were part of a larger study, involved in a road traffic accident and were brought to the accident and emergency unit of either the University of Benin Teaching Hospital (UBTH) or the State Specialist Hospital between August 2002-July 2003.The injured ones were examined and dead patients had an autopsy done on them RESULTS: A total of 51 cases of bikes riders/pillion seat passenger accidents were recorded representing 18% of total accidents. 35 motorbike riders/pillion seat passengers were struck down by cars (68.6%). Seven bike riders/pillion seat passengers (13.5%) were struck by articulated vehicles. 7 bike riders/pillion seat passengers representing 13.5% of cases were stuck by buses, 2 (3.9%) pillion seat passengers fell of bikes from epilepsies and sustained secondary injuries. Males were more in number with a ratio of 2.5; 1. One hundred percent (100%) or all motorcyclist and their passengers did not use helmets. CONCLUSION: Cars struck down most bike riders and their pillion seat passengers. Males were more than females in number. The commonest autopsy findings as cause of death was intr a-cranial hemorrhage preventable by the use of crash helmets.

Patterns of Morbidity and Mortality amongst Motorcycle Riders and their Passengers in Benin-City Nigeria: One-year Review

Objective: To evaluate patterns of morbidity and mortality among bike riders and pillion seat passengers involved in road traffic accidents in Benin-City Nigeria between August 2003-July 2004. Methods: A total of Fifty-one bike riders and pillion seat passengers; who participated in this study were part of a larger study; involved in a road traffic accident and were brought to the accident and emergency unit of either the University of Benin Teaching Hospital (UBTH) or the State Specialist Hospital between August 2002-July2003.The injured ones were examined and dead patients had an autopsy done on them. Results: A total of 51 cases of bikes riders/pillion seat passenger accidents were recorded representing 18of total accidents. 35 motorbike riders/pillion seat passengers were struck down by cars (68.6). Seven bike riders/pillion seat passengers (13.5) were struck by articulated vehicles. 7 bike riders/pillion seat passengers representing 13.5of cases were stuck by buses; 2 (3.9) pillion seat passengers fell of bikes from epilepsies and sustained secondary injuries. Males were more in number with a ratio of 2.5; 1. One hundred percent (100) or all motorcyclist and their passengers did not use helmets. Conclusion: Cars struck down most bike riders and their pillion seat passengers. Males were more than females in number. The commonest autopsy findings as cause of death was intra-cranial hemorrhage preventable by the use of crash helmets

Patterns of Morbidity and Mortality amongst Motorcycle Riders and their Passengers in Benin-City Nigeria: One-year Review

Objective: To evaluate patterns of morbidity and mortality among bike riders and pillion seat passengers involved in road traffic accidents in Benin-City Nigeria between August 2003-July 2004. Methods: A total of Fifty-one bike riders and pillion seat passengers; who participated in this study were part of a larger study; involved in a road traffic accident and were brought to the accident and emergency unit of either the University of Benin Teaching Hospital (UBTH) or the State Specialist Hospital between August 2002- July 2003.The injured ones were examined and dead patients had an autopsy done on them. Results: A total of 51 cases of bikes riders/pillion seat passenger accidents were recorded representing 18of total accidents. 35 motorbike riders/pillion seat passengers were struck down by cars (68.6). Seven bike riders/pillion seat passengers (13.5) were struck by articulated vehicles. 7 bike riders/pillion seat passengers representing 13.5of cases were stuck by buses; 2 (3.9) pillion seat passengers fell of bikes from epilepsies and sustained secondary injuries. Males were more in number with a ratio of 2.5; 1. One hundred percent (100) or all motorcyclist and their passengers did not use helmets. Conclusion: Cars struck down most bike riders and their pillion seat passengers. Males were more than females in number. The commonest autopsy findings as cause of death was intra-cranial hemorrhage preventable by the use of crash helmets

Morbidity and Mortality among Road Users in Benin-City; Nigeria

Background/objective: Murray and Krug had reported that road traffic injuries are a major cause of death globally; with disproportionate number occurring in developing counties. Seventy out of 308 deaths that occurred in Benin City from August 2002-July 2003; representing 22.7of all deaths was due to road traffic injuries. Despite this observation; there is a paucity of data on road traffic morbidity and mortality. The aim of this study was to evaluate patterns of morbidity and mortality among drivers and passengers of cars involved in road traffic accidents in Benin-City Nigeria from August 2002-July 2003 as a base line data. Methods: Eighty-seven car drivers and passengers who were studied were part of a larger study; involved in a road traffic accident and brought to the accident and emergency units of either the University of Benin Teaching Hospital or the State Specialist Hospital between August 2002- July 2003.The injured ones were examined and dead patients had autopsy done on them. Results: Over all; out of 283 total accidents cases reviewed in the period of study 87 were car occupants representing 30.7of all accident cases; and 67 patients (23.7) sustained varying injuries; while 20 patients (7.1) died. Commercial cars were involved in majority of cases 85. Males were also more in number. Intracranial hemorrhage was the predominant cause of death. Conclusion: Occupants of cars accounted for the singular most common category of morbidity and mortality among all road users. The male to female ratio was 2.1:1. Windscreen injuries most commonly associated with facial and head injuries represented the commonest cause of morbidity and mortality. The commonest autopsy finding as cause of death was intra-cranial hemorrhage

Morbidity and Mortality among Road Users in Benin-City; Nigeria

Background/objective: Murray and Krug had reported that road traffic injuries are a major cause of death globally; with disproportionate number occurring in developing counties. Seventy out of 308 deaths that occurred in Benin City from August 2002-July 2003; representing 22.7of all deaths was due to road traffic injuries. Despite this observation; there is a paucity of data on road traffic morbidity and mortality. The aim of this study was to evaluate patterns of morbidity and mortality among drivers and passengers of cars involved in road traffic accidents in Benin-City Nigeria from August 2002-July 2003 as a base line data. Methods: Eighty-seven car drivers and passengers who were studied were part of a larger study; involved in a road traffic accident and brought to the accident and emergency units of either the University of Benin Teaching Hospital or the State Specialist Hospital between August 2002-July2003.The injured ones were examined and dead patients had autopsy done on them. Results: Over all; out of 283 total accidents cases reviewed in the period of study 87 were car occupants representing 30.7of all accident cases; and 67 patients (23.7) sustained varying injuries; while 20 patients (7.1) died. Commercial cars were involved in majority of cases 85. Males were also more in number. Intracranial hemorrhage was the predominant cause of death. Conclusion: Occupants of cars accounted for the singular most common category of morbidity and mortality among all road users. The male to female ratio was 2.1:1. Windscreen injuries most commonly associated with facial and head injuries represented the commonest cause of morbidity and mortality. The commonest autopsy finding as cause of death was intra-cranial hemorrhage

Mature cystic renal teratoma in a 25-year-old woman with ipsilateral hydronephrosis, urinary tract infection and spontaneous abortion.

Benign cystic renal teratomas are uncommon clinical entities in our environment. To the best of our knowledge, it has never been reported here. Renal teratomas are rare and most have been dismissed as retroperitoneal teratomas secondarily invading the kidney. We report a case in which benign cystic renal teratoma was associated with ipsilateral hydronephrosis, urinary tract infection and spontaneous abortion, with histological confirmation in a 25-year-old woman.

Histopathological types of breast cancer in Nigerian women: a 12-year review (1993-2004).

To determine the commonest histological types of breast cancer in Nigerian women in Edo State and the mean age at diagnosis, we reviewed the histological slides of breast cancer received in the pathology department of University of Benin Teaching Hospital over a twelve-year period (January 1993-December 2004). The clinical data was obtained from the original request form and case notes where necessary. The mean age of the patients was 45.7 (SD= 13.4, SEM = 0.7). Invasive ductal carcinoma (not otherwise specified) constituted the majority of breast cancer accounting for 75.5% while papillary carcinoma was the least common (2.7%). Ductal carcinoma in situ accounted for 6.6%. Breast cancer occur more on the left (53.3%) than the right (45.7%). Bilateral breast cancer was found in only 0.8% of the cases. The frequency of invasive breast cancer is still very high among Nigerian women. Late presentation possibly due to ignorance, alternative medicine and fear of surgery may account for this high prevalence.

Pattern of malignant diseases at the University of Benin Teaching Hospital.

This study was designed to evaluate the pattern of malignant diseases seen at the University of Benin Teaching Hospital over a 20-year period (January 1980-December 1999). A total of 2258 histologically confirmed malignant diseases were seen with the predominant tumours comprising carcinoma of the cervix (20.59%), breast (18.25%), prostate (7.13%), endometrium (6.47%) and colon and rectum (5.71%). We believe that the figure reported here represents an underestimate of the frequency of malignant tumours seen in the hospital and recommend the establishment of hospital- and population-based cancer registries to ensure proper documentation of malignant diseases within the region.

Histopathology of orbito-ocular diseases seen at University of Benin Teaching Hospital, Benin City.

Ninety-three biopsied lesions of the orbito-ocular region seen over a fifteen year period at the Pathology department of the University of Benin Teaching Hospital (UBTH) Benin City were reviewed. The aim was to determine the morphological patterns and the age, sex and site distribution of these lesions. Majority of the lesions (43.3%) were found in children less than 15 years of age. There was no difference in frequency between the two sexes. 41.9% of the lesions were malignant while 58.1% were benign. The commonest site of orbito ocular lesions was conjunctival (55.9%), followed by intraocular lesions (24.7%). About 50% of the lesions of the orbit were inflammatory pseudotumours. Inflammatory pseudotumours also formed the majority (33.3%) of the lesions in the eyelid. However, squamous cell carcinomas were the commonest lesions of the conjunctiva seen accounting for 25% of these. Retinoblastomas formed 95.7% of the intra-ocular tumours seen.

Prospective study of coroner's autopsies in Benin City, Nigeria.

A prospective study of 726 cases of coroner's autopsies carried out over a period of two years (1st January, 1996 - 31st December, 1997) was reviewed. The causes and circumstances of death are defined and classified into natural and unnatural deaths. Fifty cases (6.3%) were children while the remaining 676 cases (93.1%) were adults in a male to female ratio of 2.6 to 1. The most common indications for coroner's autopsies were sudden unnatural deaths (SUDs) accounting for 485 cases (66.8%) and also sudden unexpected natural deaths (SUNDs) (241 cases) accounting for 33.2%. In the first category, road traffic accidents accounted for 86.7% of cases with deaths involving motor vehicle drivers and their passengers (41.8%); pedestrians (37.1%); and motorcyclists and their passengers (18.6%). The commonest causes of death in all road traffic accidents were craniocerebral injuries and haemorrhagic shock. In the second category the most common causes of sudden unexpected natural death were cardiovascular diseases resulting from complications of hypertension (54.7%) occurring in apparently healthy individuals. Other causes of death were pneumonia, pulmonary tuberculosis, typhoid fever and neoplastic diseases. This study showed that in Nigeria, with an increasing acquisition of dietary and life style habits of the developed western world, there is becoming a concomitant risk of deaths from road traffic accidents and sudden unexpected natural deaths from hypertensive cardiovascular disease.

Prostatic tumours in Benin City, Nigeria.

Prostatic tumours accounted for 10.2% of all surgical specimens from male patients received in the Department of Anatomic Pathology of the University of Benin Teaching Hospital, Nigeria between 1973 and 1990. Nodular prostatic hyperplasia accounted for 83% of the cases and the peak age incidence was in the sixth decade of life. Prostatic cancer occurred in the remaining 17% of the cases and the peak age incidence for occurrence was in the seventh decade of life. The commonest malignant neoplasms encountered were adenocarcinomas, out of which 64% were-well 27% moderately-and 9% poorly-differentiated. Sixty-one adenocarcinomas were classified as cases of incidental carcinoma of the prostate. Rare histological variants of prostatic cancer encountered in the present study included a case each of mucinous carcinoma, transitional cell carcinoma and rhabdomyosarcoma.