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1.
Cardiooncology ; 9(1): 3, 2023 Jan 17.
Article in English | MEDLINE | ID: mdl-36647178

ABSTRACT

Cardiac hemangiomas are very rare benign cardiac tumors. They can present at any age and clinical presentation varies according to location and size. We encountered an 87-year-old woman with a left atrial hemangioma clinically diagnosed as cardiac myxoma. Histopathological examination revealed that it was a cavernous-type hemangioma Left atrial hemangiomas, especially those attached to the left atrium wall, may be mistakenly diagnosed as myxomas. Furthermore, a comprehensive review of atrial hemangioma was conducted for the diagnosis and treatment of this uncommon entity.

3.
Radiol Case Rep ; 16(11): 3191-3195, 2021 Nov.
Article in English | MEDLINE | ID: mdl-34484517

ABSTRACT

Ectopic thyroid tissue is a rare developmental abnormality arising from an aberration in the normal migration of the thyroid gland, from the floor of the primitive foregut to its final position. It is usually asymptomatic, often being diagnosed as an incidental finding. However, it can present with symptoms of compression such as chest pain, cough, stridor, dysphagia, dyspnea and superior vena cava syndrome. Herein, we present the case of a 42-year-old male patient, presenting with dyspnea, chest pain and fatigue. Laboratory tests showed low serum levels of thyroid-stimulating hormone (TSH) and a thoracic computed tomography revealed a heterogeneous mass in the anterior mediastinum. The patient underwent a full surgical resection. The postoperative histopathological examination of the mass demonstrated the presence of benign ectopic thyroid tissue with no evidence of malignancy. This case report emphasizes the importance of taking Ectopic thyroid tissue into account when considering the differential diagnosis of a mediastinal mass, as other common diagnoses including lymphomas, dermoid cysts and thymic tumors, require an entirely distinct treatment approach.

4.
Med Arch ; 75(2): 154-157, 2021 Apr.
Article in English | MEDLINE | ID: mdl-34219877

ABSTRACT

BACKGROUND: Ectopic thyroid papillary carcinoma presenting as bilateral neck lymph nodes metastasis is very rare. Ectopic thyroid tissue may appear in any location along the trajectory of the thyroglossal duct from the foramen cecum to the mediastinum. It is subject to malignant transformation and is classically accompanied by a similar transformation of the native thyroid gland. Similar to that of the native thyroid gland, the most common malignancy found is Papillary thyroid carcinoma. Unusual cases in which ectopic thyroid carcinoma presents with normal native tissue support an alternative hypothesis that ectopic thyroid tissue may develop malignancies independently from the native thyroid gland. OBJECTIVE: We present an extremely rare case of a 30-year-old woman previously diagnosed with Hashimoto's thyroiditis, presenting with a palpable mass in the lateral neck suspicious for malignancy. RESULTS: After several examinations and surgical removal of the mass, histopathologic evaluation of the continuous sections of the thyroid, demonstrated metastatic disease from papillary carcinoma of the thyroid. Total thyroidectomy and biopsy revealed benign thyroid tissue without any foci of microcarcinoma. A hypothesis of ectopic thyroid tissue and its malignant transformation was made. CONCLUSION: By presenting this case, our goal is to highlight and make the physicians aware of the possibility of developing primary carcinoma of the ectopic thyroid tissue, without an active tumor of the thyroid gland.


Subject(s)
Carcinoma, Papillary/complications , Carcinoma, Papillary/physiopathology , Carcinoma, Papillary/surgery , Neoplasm Metastasis/physiopathology , Thyroid Cancer, Papillary/physiopathology , Thyroid Cancer, Papillary/surgery , Thyroid Dysgenesis/physiopathology , Adult , Female , Humans , Thyroid Dysgenesis/surgery , Treatment Outcome
5.
Zdr Varst ; 55(2): 108-13, 2016 Jun 01.
Article in English | MEDLINE | ID: mdl-27284380

ABSTRACT

BACKGROUND: Colorectal polyps (CP) are common among individuals older than 50 years. Some polyp types can precede colorectal cancer (CRC). This study aimed at describing histopathological characteristics of colorectal polyps in relation to age and gender among symptomatic patients referred for a colonoscopy examination during 2011-2014 in Tirana, Albania. METHODS: Study population included 267 individuals aged ≥ 20 years and diagnosed with ≥ 1 polyp during a colonoscopy examination. A total of 346 polyps were identified, excised and measured, and underwent histopathological examination. RESULTS: Adenomas accounted for 79.8% of all polyps and tubular type was the most frequent one (74.4%). The majority of polyps (42.5%) were small (<1 cm), 38.7% of a medium size (1-2 cm) and 18.8% large (>2 cm). Adenomas were larger than non-adenomatous polyps (p<0.01) There was no gender difference with regard to patient age (p=0.22) or polyp size (p=0.84) Adenomas were more frequent among men compared to women (p=0.02). Age was strongly related to polyp characteristics. The proportion of adenomas increased significantly with age (p<0.01). Within adenomas, the proportion of villous types - a precursor of colorectal cancer - increased remarkably with age (p=0.01). Older age was positively associated with potentially malignant adenomas (defined as adenomas > 1 cm and showing high-grade dysplasia) (p<0.01). CONCLUSION: Adenomas accounted for the majority of polyps. Their morphology, size and malignant potential were related to patient age.

6.
World J Surg Oncol ; 12: 243, 2014 Aug 01.
Article in English | MEDLINE | ID: mdl-25082024

ABSTRACT

BACKGROUND: Prognosis and treatment of patients with breast carcinoma of no special type (NST) is dependent on a few established parameters, such as tumor size, histological grade, lymph node stage, expression of estrogen receptor, progesterone receptor, and HER-2/neu, and proliferation index. The original Nottingham Prognostic Index (NPI) employs a three-tiered classification system that stratifies patients with breast cancer into good, moderate, and poor prognostic groups. The aim of our study was to use robust immunohistochemical methodology for determination of ER, PR, HER-2/neu, Ki-67, p53, and Bcl-2, and to observe differences in the expression of these markers when patients are stratified according to the original, three-tiered Nottingham Prognostic Index. METHODS: Paraffin blocks from 120 patients diagnosed with breast carcinoma, NST, were retrieved from our archive. Cases included in the study were female patients previously treated with modified radical mastectomy and axillary dissection. RESULTS: Our study demonstrates that expression of markers of good prognosis, such as ER, PR, and Bcl-2, is seen with higher frequency in good and moderate NPI groups. In contrast, overexpression of HER-2/neu, a marker of adverse prognosis, is more frequent in moderate and poor NPI groups. High proliferation index, as measured by Ki-67, is seen in moderate and poor NPI groups, whereas low proliferation index is seen in good NPI groups. CONCLUSIONS: These data confirm that the original, three-tiered NPI statistically correlates with the expression of prognostic immunohistochemical markers in breast carcinoma NST.


Subject(s)
Biomarkers, Tumor/metabolism , Breast Neoplasms/classification , Breast Neoplasms/metabolism , Severity of Illness Index , Breast Neoplasms/pathology , Female , Humans , Immunoenzyme Techniques , Prognosis , Proto-Oncogene Proteins c-bcl-2/metabolism , Receptor, ErbB-2/metabolism , Receptors, Estrogen/metabolism , Receptors, Progesterone/metabolism , Tumor Suppressor Protein p53/metabolism
7.
Heart Lung Circ ; 23(2): 174-6, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24200983

ABSTRACT

Intravenous leiomyomatosis (IVL) with right intracardiac extension or pulmonary benign metastases (PBM) is rare. We report a case of 51 year-old woman, who underwent successful extensive double stage surgical removal of the intracardiac IVL extension associated with a pulmonary limited resection where the cystic bullae and PBM were found, and a month later gynaecological operation. To our knowledge this is the first reported case of such a combination.


Subject(s)
Angiomyoma , Heart Neoplasms , Lung Neoplasms , Angiomyoma/diagnostic imaging , Angiomyoma/surgery , Female , Heart Neoplasms/diagnostic imaging , Heart Neoplasms/surgery , Humans , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/secondary , Lung Neoplasms/surgery , Middle Aged , Neoplasm Metastasis , Ultrasonography
8.
World J Clin Cases ; 1(6): 202-4, 2013 Sep 16.
Article in English | MEDLINE | ID: mdl-24303501

ABSTRACT

Teratomas are embryonal neoplasms that arise when totipotential germ cells escape the developmental control of primary organizers and give rise to tumors containing tissue derived from all three blastodermic layers. Teratomas have been reported to occur in various sites and organs. Teratoma of the cervical neck are relatively rare in adulthood. It usually extends from the neck to the thoracic cavity causing local mass effect. In most of the cases intrauterine diagnosis is possible by ultrasound. Because of dyspnea due to mass effect, this condition is treated promptly after birth. However cases of teratoma in adulthood with supraclavicular localization have been reported rarely in the literature. The presented case is of a 25-year-old female with a cervical mass. Histological examination revealed a benign mature teratoma. The patient has been disease free for more than nine years after surgical removal of a neck teratoma.

9.
J Infect Dev Ctries ; 6(6): 531-5, 2012 Jun 15.
Article in English | MEDLINE | ID: mdl-22706197

ABSTRACT

An unusual case of saphenous neuropathy secondary to compression by a large hydatid cyst within the adductor longus muscle is reported. Solitary hydatid cyst(s) localized in the skeletal muscles occur rarely and often mimic soft tissue tumours. Presentation with signs of peripheral nerve compression by a hydatid cyst in an extremity is exceedingly rare. Diagnosis can be established by ultrasound, computerized tomography or magnetic resonance if clinically suspected. Clinical suspicion of hydatid origin of a solitary muscle cyst should be high especially in patients hailing from areas endemic for echinococcosis. Laboratory tests are usually unhelpful in such cases and needle biopsy carries the risk of anaphylactic shock and should therefore be avoided. Surgical removal of the unruptured cyst is the treatment of choice in cases of intramuscular hydatid cyst. In the present case, excision of the hydatid cyst was followed by complete clinical recovery. In the absence of systemic involvement, treatment with albendazole may be avoided.


Subject(s)
Echinococcosis/complications , Echinococcosis/diagnosis , Femoral Neuropathy/diagnosis , Muscular Diseases/complications , Muscular Diseases/diagnosis , Nerve Compression Syndromes/diagnosis , Adolescent , Albendazole/administration & dosage , Anthelmintics/administration & dosage , Echinococcosis/pathology , Echinococcosis/surgery , Femoral Neuropathy/pathology , Humans , Male , Muscular Diseases/pathology , Muscular Diseases/surgery , Nerve Compression Syndromes/pathology , Tomography, X-Ray Computed
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