[Methodologic problems concerning pharmacology effect on bronchomotricity in asthma (Raw, V/V) (author's transl)]. / Problèmes méthodologiques pour apprécier l'action pharmacologique sur la bronchomotricité chez les asthmatiques à partir des mesures des Rva et des boucles V/V.

Study of spirometric, flow-rate and Raw modifications in three groups of 5 to 8 asthmatic patients (stage I or II) before and after acetylcholine and pneumallergen (dust) action is made. The same modifications were studied on the action of dust before and after a chemical protector effect. In two control groups the following parameters were verified: 1) the stability of Raw and V/V (normal subjects: 8); 2) the reproductibility of the acetylcholine bronchospasm, before and after the action of chemical protector (asthmatic patients: 11). Some considerations about the methodology in the practice of bronchomotricity data are submitted.

[Comparison in patients with chronic bronchitis of the data offered by the output-volume loop and the transfer capacity of CO]. / Confrontation des données de la boucle débit-volume et de la capacité de transfert du CO chez les bronchitiques chroniques

The present study concerns 78 cases of chronic bronchitis (mean age : 55,3 years) submitted to a complete enough functional respiratory study (spirometry, RV, blood gases) and distributed into three groups:--Group I: 78 cases, mean age : 55 years. All these patients were submitted to spirometry, blood gases determination and determination of the transfer capacity of CO (by making use of the method under single breath : 54 cases,--or the method with steady state : 24 cases).--Group II : 15 cases, mean age 54 years. All these patients were submitted to spirometry, blood gases determination, determination of the transfer capacity of CO with the method under single breath and to a determination of the V (60-70%) CT output on the output-volume loop.--Group III : 13 cases, mean age 53,9 years. All these patients were submitted to spirometry, blood gases determination, determination of the transfer capacity of CO with the method under steady state and a determination of the V (60-70%) CT output on the output-volume loop. The comparison of the data and the study of the eventual correlations between the various parameters determined suggests that the determination of the V (60-70 %) CT on the V/V loop is a more reliable parameter of the obstructive ventilatory syndrome than the determination of the disorders in the transfer capacity of CO. This latter method of study under steady state appears often modified when there exists an alveolar (as yet mentioned by other authors); however, this is not the case when the test is performed under single breath. In the detection of chronic bronchitis, the informations obtained with the determination of the V (60-70 %) CT output appear thus to assume a great value, but these results necessitate to be verified in a greater number of patients.