[Modern problems of modelling and treatment of soft tissues abscesses]. / Sovremennye problemy modelirovaniya i lecheniya abstsessov myagkikh tkanei.

Increase of the frequency of soft tissues pyoinflammatory diseases and purulent-septic complications against the background the antibiotic-resistance of organism dictates the necessity of search of rational new surgical technologies and preparations with the intense bactericidal effect. Period of the connective tissue (cicatrix) formation on a place of wound defect of the operated purulent abscess of soft tissue (PAST) is defined by the speed of the granulations and epithelial tissue formation. Therefore, one of the task of experimental surgery is search of new methods of the effective postoperative influence on terms of the regeneration and complete obliteration of the PAST cavity. The perspective direction in treatment of surgical infection is application of metals nanoparticles. In treatment of pyoinflammatory processes it is applied the preparation Eplan and also zinc oxide nanoparticles which have bactericidal, antiinflammatory and regenerative effects. However, till now it was not carried out experimental works on modelling and surgical treatment of PAST with local application of the laser technologies in combinations with Eplan and metals nanoparticles.

[A variant of functionally active esophagogastric anastomosis in the surgery of stenosing lesions of the esophagus]. / Variant funktsional'no aktivnogo sheinogo ézofagogastroanastomoza v khirurgii stenoziruiushchikh porazhenii pishchevoda.

A method of forming a cervical are flux esophgeal-gastric anastomosis has been developed allowing to exclude or considerably decrease the effect of esophago-gastro-pharingeal reflux on the esophageal stump mucosa after subtotal resection of the esophagus and performing one-moment esophagogastroplasty. A muscular constrictor and a circular invagination valve formed in the area of the esophagogastroanastomosis represent a single mechanism having the functional properties approximating the natural esophagocardial passage which prevents the reflux of the stomach contents into the esophagus stump and is a guarantee of prophylactics of reflux-esophagitis and stenosis of the created anastomosis.

[The correction of the disseminated intravascular coagulation syndrome in the emergency surgery of gastrointestinal tract cancer]. / Korrektsiia sindroma disseminirovannogo vnutrisosudistogo svertyvaniia krovi v neotlozhnoi khirurgii raka zheludochno-kishechnogo trakta.

The authors estimate results of correction of the hemostasis system in surgical treatment of 63 patients with complicated carcinoma of the gastro-intestinal tract. It was found that purulent peritonitis, profuse hemorrhage and obturative obstruction facilitated the development of local and generalized DIC syndrome. Methods of correction of the hemostasis system, endogenous intoxication during preoperative preparing are described. Expedience of radical operations is stressed. Complex postoperative detoxication is recommended as well as measures for the restoration of activity of the vascular-thrombocytic hemostasis and prevention of thrombus formation.

[The diagnosis and clinical assessment of the disseminated intravascular coagulation syndrome in complicated cancer of the gastrointestinal tract]. / Diagnostika i klinicheskaia otsenka sindroma disseminirovannogo vnutrisosudistogo svertyvaniia krovi pri oslozhnennom rake zheludochno-kishechnogo trakta.

Under study were the state of the hemostasis system, the level of endogenous intoxication and anti-infectional defense in 63 patients with complicated carcinoma of the gastro-intestinal tract (GIT). It was established that the patients had the syndrome of disseminated intravascular coagulation (DIC) of blood which at first was of local character. Acute complications of carcinoma of GIT, first of all purulent peritonitis and profuse gastro-intestinal bleedings, aggravate endotoxicosis and facilitate the development of the acute DIC syndrome. A conception of the development of the intoxicative DIC syndrome is presented and proposed are informative methods of the assessment of hemostasis in emergency surgery of carcinoma of the GIT.

[Correction of endogenous poisoning in patients with peritonitis in gastric and intestinal tumors]. / Korrektsiia éndogennoi intoksikatsii pri peritonite u bol'nykh s opukholiami zheludka i kishechnika.

Peculiarities of endogenous intoxication in peritonitis in 63 patients with cancer of the stomach and intestine were studied. Three degrees of the intoxication syndrome severity were distinguished: the mild, moderate and severe ones. It is shown that the severity degree of intoxication depends on a phase of peritonitis, stage of tumorous process and state of anti-infective protection of an organism. The steps for surgical detoxication of an organism, depending on severity degree of endogenous intoxication, were defined. Use of a complex of treatment permitted to reduce postoperative lethality of the patients to 33%.

[Characteristics of peritonitis in cancer of the gastrointestinal tract]. / Osobennosti peritonita pri rake zheludochno-kishechnogo trakta.

Under analysis was material of treatment of 63 patients with gastric and colonic cancer complicated by acute peritonitis. An atypical asymptomatic course of the subreactive and a reactive forms of peritonitis is associated with pronounced inhibition of factors of antiinfection defense in elderly patients with the III-IV degrees of cancer. Complex stimulating therapy is indicated in the postoperative period because of immunodepression taking place after urgent operative interventions.

[Diagnosis and treatment of acute intestinal obstruction in cancer of the large intestine]. / Diagnostika i lechenie ostroi kishechnoi neprokhodimosti pri rake tolstoi kishki.

A complex program of treatment of acute intestinal obstruction in carcinoma of the large bowel has been developed on the basis of an analysis of 71 patients. Urgent operations were performed in 70% of the patients with acute intestinal obstruction after a short preoperative preparing. Due to substantial metabolic and immunologic shifts the complex parenteral immunostimulating therapeutic measures are necessary in the postoperative period for all the patients.

[Complicated forms of gastrointestinal cancer in emergency surgery]. / Oslozhnennye formy raka zheludochno-kishechnogo trakta v neotlozhnoi khirurgii.

The authors give the definition of the term "complicated form" and classify the complications of gastro-intestinal carcinomas. The results of the treatment of 225 patients with complications of gastro-intestinal carcinomas are analyzed, 142 of them being subjected to urgent surgery. Complete occlusion ileus, peritonitis and continuous hemorrhage were considered by the authors to be indications for urgent operations.

[Clinico-morphological characteristics of acute cholecystitis]. / Kliniko-morfologicheskaia kharakteristika ostrogo kholetsistita.

The clinical picture and morphological changes of the bile cyst were compared in 120 patients operated for acute cholecystitis. In 9% of cases no agreement was observed between the clinical picture of the disease and morphological changes of the bile cyst wall.