ABSTRACT
A 45-year-old male presented with a large mass in the left axilla. FNA cytology was interpreted as Hodgkin's disease (HD), lymphocyte depletion (LD) type, but histopathologic and immunohistochemical examination showed features of Ki-1-positive anaplastic large cell lymphoma. Unrepresentative sampling by the FNA from the tumour periphery resulted in a false impression of dual reactive and neoplastic cell populations, which together with the frequent Reed-Sternberg-like cells led to the initial erroneous impression of HD. Therefore, the cytologic diagnosis of HD, LD should be approached with caution.
Subject(s)
Hodgkin Disease/diagnosis , Lymphoma, Large-Cell, Anaplastic/pathology , Antigens, CD/analysis , Biopsy, Needle , Diagnostic Errors , Hodgkin Disease/pathology , Humans , Immunohistochemistry , Lymph Nodes/pathology , Lymphoma, Large-Cell, Anaplastic/ultrastructure , Male , Middle Aged , Reed-Sternberg Cells/pathologyABSTRACT
An Arab female child presented with rapidly progressive liver disease, with apparent onset in late infancy and death at 15 months. Microscopy showed panacinar hepatitis, portal and pericellular fibrosis, and diffuse Mallory bodies in the absence of steatosis or significant cholestasis. Hepatic copper concentration was moderately elevated. Known causes of early childhood cirrhosis were excluded. This case meets most of the established criteria of Indian childhood cirrhosis, yet is unusual in its occurrence in a child of Arab ancestry and in having a moderate degree of hepatocellular copper overload.
