ABSTRACT
Drug resistance is a hot topic issue in cancer research and therapy. Although cancer therapy including radiotherapy and anti-cancer drugs can kill malignant cells within the tumor, cancer cells can develop a wide range of mechanisms to resist the toxic effects of anti-cancer agents. Cancer cells may provide some mechanisms to resist oxidative stress and escape from apoptosis and attack by the immune system. Furthermore, cancer cells may resist senescence, pyroptosis, ferroptosis, necroptosis, and autophagic cell death by modulating several critical genes. The development of these mechanisms leads to resistance to anti-cancer drugs and also radiotherapy. Resistance to therapy can increase mortality and reduce survival following cancer therapy. Thus, overcoming mechanisms of resistance to cell death in malignant cells can facilitate tumor elimination and increase the efficiency of anti-cancer therapy. Natural-derived molecules are intriguing agents that may be suggested to be used as an adjuvant in combination with other anticancer drugs or radiotherapy to sensitize cancer cells to therapy with at least side effects. This paper aims to review the potential of triptolide for inducing various types of cell death in cancer cells. We review the induction or resistance to different cell death mechanisms such as apoptosis, autophagic cell death, senescence, pyroptosis, ferroptosis, and necrosis following the administration of triptolide. We also review the safety and future perspectives for triptolide and its derivatives in experimental and human studies. The anticancer potential of triptolide and its derivatives may make them effective adjuvants for enhancing tumor suppression in combination with anticancer therapy.
Subject(s)
Antineoplastic Agents , Diterpenes , Neoplasms , Humans , Neoplasms/drug therapy , Cell Death , Apoptosis , Diterpenes/pharmacology , Diterpenes/therapeutic use , Antineoplastic Agents/pharmacology , Antineoplastic Agents/therapeutic useABSTRACT
The novel Ag0/Cu2MoO4 nanoparticles was simply synthesized via chemical method. Ag/Cu2MoO4 nanoparticles was characterized by FESEM image, XRD curve, UV-vis spectroscopy, BET analysis, and XPS spectrum. XRD pattern depicts that the cubic crystalline phase of particles. The band gap of Ag/Cu2MoO4 nanoparticles was achieved to 2.04 eV, which that depicted the best activity under visible light irradiation. Ag/Cu2MoO4 nanoparticles exhibits 99.74% degradation under light and persulfate ion which was higher response than Cu2MoO4 nanoparticles (83.56%) under this condition. The scavenging test indicates the important reactive species in removal process were â¢OH, and â¢SO4-. The Ag/Cu2MoO4 nanoparticles was indicated highly photo-stability for the MG degradation after 5th cycle. Ag/Cu2MoO4 exhibits substantial antibacterial properties against P. aeruginosa and S. pneumoniae. Moreover, Ag/Cu2MoO4 nanoparticles was experimented to peroxidase-like performance for the colorimetric detection of glucose with the Limit of Detection about 52.23 nM.
Subject(s)
Glucose , Nanoparticles , Catalysis , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/chemistry , LightABSTRACT
Negative emotions reduce the academic achievement of college students. Students in Iraq experience bad emotions due to the country's social conditions. The purpose of this project is to improve the mental health of Iraqi students through physical activity. This study aims to examine the moderating link between psychological resilience and negative emotions among university students in Iraq. This study collects quantitative data using a Likert scale questionnaire and a random sample technique; the participants were students from several Najaf universities. The findings of this study indicate that physical health plays a substantial moderating influence between psychological resilience and unpleasant emotions. According to the study, students' negative feelings can be lessened with health education and mental health literacy. These findings are unusual since this study's theoretical framework offers a substantial relationship to the existing research. Similar to the theoretical implications, this study has significant practical consequences that are crucial to consider while attempting to reduce the negative emotions component among Iraqi university students. The next directions of this research are important for addressing the literature gap in negative emotions.(AU)
