ABSTRACT
INTRODUCTION: Burned patients are at high risk of yeast colonization and thus of invasive fungal infections, particularly to Candida (C.) spp., leading to an increase in morbidity and mortality. While pre-emptive antifungal therapy has improved survival, it may lead to an increase in antifungal resistance. The objectives of this work were to describe Candida species distribution and to determine the antifungal susceptibility of Candida isolates acquired in a burn unit.
ABSTRACT
BACKGROUND: Pseudomonas aeruginosa plays a predominant role as an etiological agent involved in serious infections in burned patients. Treatment of these infections is frequently complicated by antibiotic resistance, a problem that is is increasing in recent years. AIM: The objective of this study is to analyze epidemiological profile and antibiotic susceptibility of P. aeruginosa isolates within the burned patients admitted in our intensive care department. METHODS: During a period of 4 years (2000/2003), 828 burn patients were admitted. RESULTS: The survey of antibiotic susceptibility of P. aeruginosa showed high percentages of resistance to the different antibiotics. 60.9% of strains were resistant to piperacillin, 53.4% to ceftazidime, 37.6% to imipenem, 70.6% to cefsulodine, 59.3% to tobramycin, 80% to gentamicin, 62.4% to amikacin and 53.4% to ciprofloxacin. CONCLUSION: It is necessary to implement urgent measures to prevent the spreading of this multiresistant strain. These measures include: sensible limitation of the use of antimicrobial agent, strict disinfection and hygienic procedures.
Subject(s)
Burns/microbiology , Drug Resistance, Multiple, Bacterial , Pseudomonas Infections/drug therapy , Adolescent , Adult , Aged , Burn Units , Burns/epidemiology , Child , Cross Infection/drug therapy , Cross Infection/microbiology , Humans , Intensive Care Units , Middle Aged , Pseudomonas aeruginosa/isolation & purification , Tunisia/epidemiologyABSTRACT
The purpose of this work is to study the bacteriological profiles of germ responsible for bacteriemas / septicemias in badly burnt patients hospitalized in burns utis, in order to guide better the antibiotherapy of first intention. During the period of survey going from January 1st, 2001 to December 31st,2002 71 patients had one or several episodes of bateremia. The average burnt cutaneous surface was 48.7%. All collected bacteriemas were contacted in hospial. Empirical antbiotheray was effective in 30 patients. The hospital stay for this group was long: 45 to 86 days. Acinetobacter baumannii was the most incriminated germ(20.3%), followed klebsiella pneumoniea (12.7%). The frequency of resistance was variable according to the considered species.
