ABSTRACT
The efficacy of a prolonged (an average of 24.2 days) subcutaneous insulin administration using a Soviet apparatus NDL (a portable drug dosing apparatus) of paracorporal type was studied in 30 patients with type I diabetes mellitus. As a result of therapy a stable compensation of carbohydrate metabolism was achieved in 26 patients, subcompensation in 4 patients; glycemia circadian variations and requirements in insulin in most cases decreased. Simultaneously a clinical improvement of the patients' general status was observed. The use of a prolonged subcutaneous administration of insulin using the NDL was recommended for patients with insulin-dependent diabetes mellitus with a grave form, a labile course and insulin resistance that was difficult to control.