Subject(s)
Bacterial Proteins/metabolism , Carbapenem-Resistant Enterobacteriaceae/metabolism , Enterobacteriaceae Infections , beta-Lactamases/metabolism , Carbapenem-Resistant Enterobacteriaceae/enzymology , Carbapenems/therapeutic use , Enterobacteriaceae Infections/drug therapy , Enterobacteriaceae Infections/epidemiology , Enterobacteriaceae Infections/metabolism , Global Health/statistics & numerical data , Humans , Quebec/epidemiologyABSTRACT
In response to 2 reported cases of nosocomial legionellosis after anti-tumor necrosis factor (TNF) treatment, the environmental controls and testing facilities in a 221-bed acute care hospital were investigated. This investigation led to the implementation of a series of specific preventive measures adapted from protocols used to protect immunosuppressed patients. These 2 cases of legionellosis might be related to 2 concurrent events: treatment of hospitalized patients with anti-TNF drugs and secondary environmental changes related to major construction work. Patients undergoing anti-TNF treatment may be at increased risk for developing opportunistic infections during construction work, renovations, or water supply perturbations and require specific preventive measures.
