ABSTRACT
La sarcoidosis es una afección multisistémica, de etiología desconocida y evolución crónica, en general benigna. Los órganos mayormente comprometidos son (..) (AU)
Sarcoidosis is, in generally, a benign multisystemic disease of unknown etiology (..) (AU)
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Sarcoidosis/complications , Subcutaneous Tissue/physiopathology , Skin Diseases/etiologyABSTRACT
BACKGROUND: Eating disorders are increasing and show a variety of symptoms. They mainly include anorexia nervosa (AN), bulimia nervosa (BN), and eating disorders not specified (EDNOS). They predominate in females and represent an important danger, especially in teenagers. In serious cases, they may be life-threatening. Objective To determine the prevalence of cutaneous findings in patients with eating disorders and to compare the results with those found in the literature. METHODS: An observational, transverse, and prospective study was performed. Two hundred patients of recent admission to ALUBA (association that fights against BN and AN), a psychiatric unit for eating disorders, were included: 122 BN; 62 AN; 16 EDNOS. RESULTS: Patients with eating disorders show dermatologic manifestations (alopecia, xerosis, hypertrichosis, caries, nail fragility) that are secondary to starvation. Russell's sign, seen as calluses on the dorsal aspect of the hands, is a consequence of self-induced vomiting and the local trauma of the superior incisors. This sign represents a compensatory behavior to overeating and predominates in the BN group. CONCLUSION: The recognition of dermatologic signs could be of immense value and could lead to the early diagnosis and treatment of these eating disorders.
Subject(s)
Feeding and Eating Disorders/complications , Feeding and Eating Disorders/diagnosis , Skin Diseases/epidemiology , Skin Diseases/etiology , Adolescent , Adult , Age Distribution , Argentina/epidemiology , Confidence Intervals , Female , Humans , Male , Prevalence , Prospective Studies , Sex DistributionABSTRACT
Patients with lymphomas and cutaneous ulcers have a poor prognosis. Commonly the ulcers occur later in the course of lymphomas and may be the source of sepsis. From 59 patients with lymphoma and skin involvement, 12 patients who presented with ulcers were retrospectively analyzed between January 1990 to December 1999. More frequently ulcers were multiple, necrotic, infected and placed on tumors. Sepsis was the main cause of mortality in 10 patients and most cases were secondary to Staphylococcus aureus and Pseudomonas aeruginosa. Factors associated with poor prognosis were febrile neutropenia after chemotherapy and generalized involvement by the lymphoma. Mean survival of deceased patients after onset of ulcers was 6.27 months. We emphasize the importance of an appropriate microbiological study and a prompt therapy.
Subject(s)
Lymphoma, T-Cell, Cutaneous/pathology , Skin Neoplasms/pathology , Varicose Ulcer/pathology , Adult , Aged , Aged, 80 and over , Female , Humans , Lymphoma, Non-Hodgkin/complications , Lymphoma, Non-Hodgkin/pathology , Lymphoma, T-Cell, Cutaneous/complications , Male , Middle Aged , Retrospective Studies , Skin Neoplasms/complications , Varicose Ulcer/microbiologyABSTRACT
Patients with lymphomas and cutaneous ulcers have a poor prognosis. Commonly the ulcers occur later in the course of lymphomas and may be the source of sepsis. From 59 patients with lymphoma and skin involvement, 12 patients who presented with ulcers were retrospectively analyzed between January 1990 to December 1999. More frequently ulcers were multiple, necrotic, infected and placed on tumors. Sepsis was the main cause of mortality in 10 patients and most cases were secondary to Staphylococcus aureus and Pseudomonas aeruginosa. Factors associated with poor prognosis were febrile neutropenia after chemotherapy and generalized involvement by the lymphoma. Mean survival of deceased patients after onset of ulcers was 6.27 months. We emphasize the importance of an appropriate microbiological study and a prompt therapy.
Subject(s)
Hemangioma/congenital , Hemangioma/radiotherapy , Hemangiosarcoma/pathology , Neoplasms, Radiation-Induced/pathology , Neoplasms, Second Primary/pathology , Skin Neoplasms/congenital , Skin Neoplasms/radiotherapy , Aged , Face , Hemangiosarcoma/secondary , Hemangiosarcoma/surgery , Humans , Male , Neoplasms, Radiation-Induced/secondary , Neoplasms, Radiation-Induced/surgery , Neoplasms, Second Primary/secondary , Neoplasms, Second Primary/surgery , Skin Neoplasms/pathologyABSTRACT
BACKGROUND: Nevus spilus is found with relative frequency. It is observed as as tan to brown macule serving as base to a speckle of smaller and darker maculo-papular elements. On rare occasions it turns into a malignant melanoma. PURPOSES: To describe one case with some characteristics different from routine observations and to revise the cases published reporting nevus spilus that turned into malignant melanoma, in order to point out the most frequent aspects. RESULTS: The 17 patients with nevus spilus and melanomas, including ours, were white, with ages between 35 and 56 years. Most of the cases were localized in the dorsal region. Five patients were men. Almost all nevus were congenital and their size ranged between 2 and 10 cm in diameter. Histologically, the speckled spots were junctional nevus, and few of them had dysplastic characteristics. Melanomas corresponded to the extensive superficial type MES; one of them was nodular. Some had systemic ganglial metastases and three of the patients are known to have died. Our patient had an intradermal cellular nevus on the man spot, and terminal hairs could be observed on it. The speckled elements were junctional nevus with dysplastic cells. CONCLUSIONS: Nevus spilus must be closely monitored, because it may turn into a malignant melanoma.
Subject(s)
Cell Transformation, Neoplastic/pathology , Melanoma/pathology , Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Adult , Biopsy, Needle , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Male , Melanoma/diagnosis , Melanoma/surgery , Middle Aged , Nevus, Pigmented/complications , Nevus, Pigmented/congenital , Skin Neoplasms/diagnosis , Skin Neoplasms/surgeryABSTRACT
Se presenta un estudio observacional,prospectivo y transversal de 122 pacientes con bulimia nerviosa.El objetivo fue determinar la prevalencia de trastornos cutáneos en esta población y la comparación con lo reportado en la bibliografía.Las principales manifestaciones dermatológicas fueron:xerosis,acné,alopecía,caries,hipertricosis y signo de Rusell.Teniendo en cuenta que estas manifestaciones pueden ser los primeros signos que orienten hacia este trastorno de la conducta alimentaria que está en franco aumento,consideramos de fundamental importancia,estar alertados sobre la existencia del mismo.Un diagnóstico precoz será de inestimable valor para iniciar un tratamiento adecuado cutáneo y extracutáneo
Subject(s)
BulimiaABSTRACT
Se presenta un estudio observacional,prospectivo y transversal de 122 pacientes con bulimia nerviosa.El objetivo fue determinar la prevalencia de trastornos cutáneos en esta población y la comparación con lo reportado en la bibliografía.Las principales manifestaciones dermatológicas fueron:xerosis,acné,alopecía,caries,hipertricosis y signo de Rusell.Teniendo en cuenta que estas manifestaciones pueden ser los primeros signos que orienten hacia este trastorno de la conducta alimentaria que está en franco aumento,consideramos de fundamental importancia,estar alertados sobre la existencia del mismo.Un diagnóstico precoz será de inestimable valor para iniciar un tratamiento adecuado cutáneo y extracutáneo
Subject(s)
BulimiaSubject(s)
Connective Tissue Diseases/chemically induced , Hyperpigmentation/chemically induced , Silicones/adverse effects , Adult , Buttocks , Connective Tissue Diseases/pathology , Connective Tissue Diseases/physiopathology , Humans , Hyperpigmentation/pathology , Hyperpigmentation/physiopathology , Injections, Intramuscular , Magnetic Resonance Imaging , Male , Silicones/administration & dosageABSTRACT
BACKGROUND AND OBJECTIVES: Burning mouth syndrome (BMS) is a frequent process that produces marked oral dysesthetic symptoms. There is controversy over its etiopathogenesis and diagnosis. Therapeutic results are unsatisfactory. The objectives of this study were: (1) to analyze a possible agreement on the definition of BMS; (2) to analyze its cause; (3) to propose a therapeutic scheme that has been shown to be highly effective in our experience and has not been previously reported. METHODS: Five hundred patients with symptomatology of BMS were retrospectively evaluated with a study protocol, specially designed for this disease. Patients with local or general disease processes that could cause secondary asymptomatic stomatodynia were excluded from the study. RESULTS: Most of the patients evaluated were women over 60 years of age with oral symptoms, including a sensation of heat and burning, and pain, lasting for months or years, and a history of multiple unsuccessful treatments. The patients showed depression associated with anxiety, with evidence of psychiatric disorders in the family. Based on these findings and eliminating symptomatic painful conditions of the mouth that may stimulate this syndrome, we diagnosed a genuine or basic BMS of psychosomatic origin. Therapies used in the treatment of these neurotic conditions were not always useful. Tranylcypromine associated with anxiolytics and hypnotics in low doses plus the support of psychotherapy by the stomatologist were the most effective treatments. CONCLUSIONS: The BMS should be defined as a psychosomatic process causing oral dysesthesias for months or years.
Subject(s)
Burning Mouth Syndrome , Adult , Age Distribution , Aged , Aged, 80 and over , Anti-Anxiety Agents/therapeutic use , Antidepressive Agents/therapeutic use , Antidepressive Agents, Tricyclic/therapeutic use , Burning Mouth Syndrome/epidemiology , Burning Mouth Syndrome/etiology , Burning Mouth Syndrome/physiopathology , Burning Mouth Syndrome/therapy , Female , Humans , Male , Middle Aged , Prognosis , Retrospective Studies , Sex Distribution , Socioeconomic FactorsSubject(s)
Pemphigus , Adolescent , Adult , Argentina , Brazil , Child , Humans , Male , Pemphigus/epidemiology , South America , Surveys and QuestionnairesABSTRACT
La alopecía areata puede manifestarse por pérdida total del vello corporal a alopecía universal (AU), habiéndose descripto alteraciones tiroideas y de autoinmunidad asociadas. En el presente estudio, dichas alteraciones fueron investigadas en un grupo de niños portadores de alopecía universal. Se estudiaron 11 niños (4 niños y 7 varones) de 2 a 13 años de edad que presentaban AU de 1 a 10 años de evolución: el grupo control fue constituido por 9 niños normales ( 2 niñas y 7 varones) de 7 a 13 años de edad. La talla y peso de todos los niños fueron normales salvo 3 alopécicos que se hallaban por debajo del percentilo 3; la edad ósea fue normal en todos los niños. Todos se hallaban clínicamente eutiroideos salvo la paciente nº 1 quien presentaba hipotiroidismo franco. Se encontró discreta hipertrofia tiroidea en 5 de 11 alopécicos pero sólo en 1 de los 9 controles. Se realizaron determinaciones de T3, T4, T4libre, TSH basal y post-TRH por RIA. Se determinaron anticuerpos antitiroglobulina por hemaglutinación pasiva y otros anticuerpos órgano-específicos y no órgano-específicos (antimicrosomales tiroideos, célula parietal y adrenal, antinucleares, mitocondria, ribosoma, músculo liso y estriado) por inmunofluorescencia. Las concentraciones basales de T3, T4, T4 libre y TSH fueron normales y sin diferencias significativas entre ambos grupos. Si bien el incremento medio de TSH post-TRH fue mayor en el grupo AU que en los controles (Tabla 2), la diferencia no fue estadísticamente significativa. Tampoco se detectaron anomalías significativas en la presencia de autoanticuerpos. Pese a la negatividad de estos hallazgos, la mayor frecuencia de hipertrofia tiroidea en el grupo AU que en los controles justifica un seguimiento longitudinal (AU)
Subject(s)
Child, Preschool , Child , Adolescent , Humans , Male , Female , Alopecia , Autoantibodies/analysis , Thyroid Gland/physiopathology , Thyroid Diseases/etiology , Thyroid Function TestsABSTRACT
La alopecía areata puede manifestarse por pérdida total del vello corporal a alopecía universal (AU), habiéndose descripto alteraciones tiroideas y de autoinmunidad asociadas. En el presente estudio, dichas alteraciones fueron investigadas en un grupo de niños portadores de alopecía universal. Se estudiaron 11 niños (4 niños y 7 varones) de 2 a 13 años de edad que presentaban AU de 1 a 10 años de evolución: el grupo control fue constituido por 9 niños normales ( 2 niñas y 7 varones) de 7 a 13 años de edad. La talla y peso de todos los niños fueron normales salvo 3 alopécicos que se hallaban por debajo del percentilo 3; la edad ósea fue normal en todos los niños. Todos se hallaban clínicamente eutiroideos salvo la paciente n§ 1 quien presentaba hipotiroidismo franco. Se encontró discreta hipertrofia tiroidea en 5 de 11 alopécicos pero sólo en 1 de los 9 controles. Se realizaron determinaciones de T3, T4, T4libre, TSH basal y post-TRH por RIA. Se determinaron anticuerpos antitiroglobulina por hemaglutinación pasiva y otros anticuerpos órgano-específicos y no órgano-específicos (antimicrosomales tiroideos, célula parietal y adrenal, antinucleares, mitocondria, ribosoma, músculo liso y estriado) por inmunofluorescencia. Las concentraciones basales de T3, T4, T4 libre y TSH fueron normales y sin diferencias significativas entre ambos grupos. Si bien el incremento medio de TSH post-TRH fue mayor en el grupo AU que en los controles (Tabla 2), la diferencia no fue estadísticamente significativa. Tampoco se detectaron anomalías significativas en la presencia de autoanticuerpos. Pese a la negatividad de estos hallazgos, la mayor frecuencia de hipertrofia tiroidea en el grupo AU que en los controles justifica un seguimiento longitudinal
Subject(s)
Child, Preschool , Child , Adolescent , Humans , Male , Female , Alopecia , Autoantibodies/analysis , Thyroid Gland/physiopathology , Thyroid Diseases/etiology , Thyroid Function TestsABSTRACT
A patient with renal transplant developed muco-cutaneous Kaposi's sarcoma. The tumors appeared within a mont after surgery, while receiving daily 240 mgr . of methylprednisone and 150 mgr . of azathioprine. She received superficial radiotherapy ( Cesio 137) on her cutaneous lesions and the nasal tumor was removed with Laser radiation CO2 obtaining a favorable a response. Possible etiopathogenic mechanisms are mentioned. Clinical, epidemiologic, therapeutic and prognosis features of these transplanted subjects are discussed. Publications of other similar cases are reviewed.
Subject(s)
Kidney Transplantation , Neoplasms, Multiple Primary/etiology , Nose Neoplasms/etiology , Sarcoma, Kaposi/etiology , Skin Neoplasms/etiology , Adult , Female , Humans , Neoplasms, Multiple Primary/pathology , Neoplasms, Multiple Primary/therapy , Nose Neoplasms/surgery , Postoperative Complications , Radiotherapy Dosage , Sarcoma, Kaposi/pathology , Sarcoma, Kaposi/radiotherapy , Skin Neoplasms/pathology , Skin Neoplasms/radiotherapyABSTRACT
A proposito de dos observaciones de tricorrexis nudosa, se hace una breve referencia a los antecedentes historicos de la enfermedad y a sus formas clinicas: congenita y adquirida. Dado que la forma adquirida de tricorrexis nudosa es resultado de traumas fisicos e quimicos, con o sin diatesis sistemica, se presume que pueda incrementar su aparicion debido al avance de la cosmetica capilar y la aceptacion de la misma por ambos sexos
Subject(s)
Adult , Humans , Male , Scalp DermatosesABSTRACT
A proposito de dos observaciones de tricorrexis nudosa, se hace una breve referencia a los antecedentes historicos de la enfermedad y a sus formas clinicas: congenita y adquirida. Dado que la forma adquirida de tricorrexis nudosa es resultado de traumas fisicos e quimicos, con o sin diatesis sistemica, se presume que pueda incrementar su aparicion debido al avance de la cosmetica capilar y la aceptacion de la misma por ambos sexos
