Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Database
Language
Publication year range
1.
Drugs R D ; 23(2): 93-98, 2023 Jun.
Article in English | MEDLINE | ID: mdl-36988798

ABSTRACT

BACKGROUND AND OBJECTIVE: Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole. CASE: Here, we present the case of a 62-year-old patient who developed agranulocytosis as well as hemolysis after a single administration of metamizole. CONCLUSION: This case illustrates the inherent allergic potential of metamizole and its effects on different hematopoietic cell types.


Subject(s)
Agranulocytosis , Neutropenia , Humans , Middle Aged , Dipyrone/adverse effects , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Hemolysis , Agranulocytosis/chemically induced
2.
Biomark Med ; 16(4): 265-275, 2022 03.
Article in English | MEDLINE | ID: mdl-35176879

ABSTRACT

Aim: NAG and KIM-1 as markers of tubular damage are suggested as potential biomarkers for the cardiorenal syndrome. The aim of the study was to assess the prognostic capability of NAG and KIM-1 regarding progression of chronic kidney disease (CKD) in patients with implantable cardioverter defibrillator (ICD). Materials & methods: We included 313 patients with an ICD and collected plasma and urine samples. Follow-up was performed after 51 months (interquartile range [IQR]: 25-55). The outcome of interest was continuous CKD progression defined as persistent decline in estimated glomerular filtration rate category accompanied by a ≥25% drop of baseline estimated glomerular filtration rate. Results: An average of four (IQR: 2-6) follow-up values of serum creatinine per patient were obtained. During follow-up 29 patients (9%) developed a continuous CKD progression. NAG was shown as independent predictor for continuous CKD progression (p = 0.01), opposite to KIM-1 (p = n.s.). Conclusion: NAG was shown as predictor for a progressive and real deterioration of kidney function in patients with ICD.


Subject(s)
Cardio-Renal Syndrome , Defibrillators, Implantable , Renal Insufficiency, Chronic , Biomarkers , Disease Progression , Female , Glomerular Filtration Rate , Humans , Male , Renal Insufficiency, Chronic/complications , Renal Insufficiency, Chronic/therapy
3.
Nephrology (Carlton) ; 25(12): 888-896, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32841436

ABSTRACT

AIMS: Chronic heart failure may lead to chronic kidney disease. Previous studies suggest tubular markers N-acetyl-b-D-glucosaminidase (NAG) and Kidney-injury-molecule-1 (KIM-1) as potential markers for the cardiorenal syndrome (CRS). The prognostic value of NAG and KIM-1 regarding implantable cardioverter defibrillator (ICD) shock therapies is unknown. METHODS: We included 314 patients with an ICD and collected plasma and urine samples. Urine-values of NAG and KIM-1 got related to urinary creatinine. Outcomes of interest were sustained adequate shock therapies and a combined endpoint of all-cause mortality, rehospitalisation due to congestive heart failure and adequate shock therapies. Follow up time was 32 months (IQR 6-35 months). RESULTS: KIM-1 and NAG were positively correlated with NT-proBNP (KIM-1: r = .34, P < .001; NAG: r = .47, P < .001). NAG was significantly elevated in patients with primary prevention compared with secondary prevention ICD indication (P = .003). According to Kaplan Meier analysis, NAG as well as NT-proBNP were significant predictors for adequate ICD shock therapies and for the combined endpoint (each P < .001). Elevated KIM-1 showed no significant differences (each P = n.s.). In multivariate cox regression analysis, NAG as well as NT-proBNP were both independent predictors for adequate ICD shock therapies as well as the combined endpoint, beside ejection fraction <35% (each P < .05). Diabetes, primary prevention ICD indication, coronary artery disease, eGFR and age were no significant predictors for both endpoints (each P = n.s.). CONCLUSION: Similar to NT-proBNP, NAG showed promising value for overall prognostication in ICD patients. Especially, NAG seems to incorporate an additional prognostic value regarding occurrence of ICD shock therapies.


Subject(s)
Acetylglucosaminidase/metabolism , Arrhythmias, Cardiac/metabolism , Arrhythmias, Cardiac/mortality , Cardio-Renal Syndrome/etiology , Defibrillators, Implantable , Electric Countershock , Adult , Aged , Arrhythmias, Cardiac/therapy , Biomarkers/metabolism , Cardio-Renal Syndrome/diagnosis , Cardio-Renal Syndrome/metabolism , Creatinine/urine , Female , Hepatitis A Virus Cellular Receptor 1/metabolism , Hospitalization , Humans , Male , Middle Aged , Natriuretic Peptide, Brain/blood , Peptide Fragments/blood , Predictive Value of Tests , Prognosis , Retrospective Studies , Survival Rate , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL
...