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Colloids Surf B Biointerfaces ; 189: 110850, 2020 May.
Article in English | MEDLINE | ID: mdl-32058257

ABSTRACT

The purpose of this study was to evaluate the efficacy of imiquimod-containing nanovesicles prepared with lipids extracted from the hyperhalophile archaebacterium Halorubrum tebenquichense (nanoARC-IMQ) to induce protection against Trypanosoma cruzi infection. The therapeutic efficacy of archaeolipid nanovesicles was assessed in an experimental murine model of acute infection with T. cruzi. The administration of nanoARQ-IMQ prevented mortality as compared to infected untreated animals, reduced parasitemia levels and diminished myocardial and musculoskeletal lesions in mice infected with a lethal strain of T. cruzi. Our findings suggest that the immunotherapy with nanoARC-IMQ has potential to limit the progression of Chagas disease.


Subject(s)
Adjuvants, Immunologic/therapeutic use , Chagas Disease/therapy , Imiquimod/therapeutic use , Immunotherapy , Nanoparticles/therapeutic use , Adjuvants, Immunologic/chemistry , Animals , Chagas Disease/pathology , Imiquimod/chemistry , Lipids/chemistry , Male , Mice , Mice, Inbred C3H , Nanoparticles/chemistry , Particle Size , Surface Properties
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