[Changes in indicators of the antioxidant defense system in patients with ischemic heart disease treated conventionally]. / Izmenenie pokazatelei sistemy antioksidantnoi zashchity organizma u bol'nykh ishemicheskoi bolezn'iu serdtsa na fone traditsionnoi terapii.

Parameters of antioxidant defense including superoxide dismutase, catalase and spontaneous chemiluminescence were studied in 68 patients with ischemic heart disease and 20 control patients. The above parameters decreased with the disease aggravation. Conventional therapy has improved antioxidant defense, the effect being dependent on effect of therapy irrespective of its variant.

[Myocardial function in patients with type I diabetes mellitus]. / Funktsional'noe sostoianie miokarda u bol'nykh sakharnym diabetom I tipa.

Myocardial contractility was examined in patients with type I diabetes mellitus without coronary disease by selective tolerance test with transesophageal heart stimulation using doppler cardiography. Nineteen diabetics aged 17 to 36 with the disease duration from 0 to 20 years were examined. Maximal ejection time before and after the test was assessed. The findings indicate impaired myocardial contractility in the examinees, though clinical signs of manifest circulation insufficiency were undetectable in all the patients. The authors come to a conclusion on the significance of diabetes duration and severity in development of myocardial injury.

[Laser acupuncture in the complex treatment of stenocardia]. / Lazeropunktura v kompleksnoi terapii stenokardii.

Acupuncture points were exposed to helium-neon laser beam in 200 anginal patients. This therapeutic modality yielded good results: the number of attacks and nitroglycerin intake reduced, exercise tolerance grew, echocardiographic evidence showed a positive trend, hemodynamics improved, Spilberger's test values changed for the better.

[Clinical characteristics and diagnosis of stenocardia in persons with normal coronary vessels]. / Klinicheskie osobennosti i diagnostika stenokardii u lits s normal'nymi koronarnymi sosudami.

To date, the clinical pattern and electrocardiographic diagnosis of only one variant of coronary heart disease (CHD) with unchanged coronarogram, Prinzmetal's angina, have been worked out, while the diagnosis of other variants remains undeveloped. Clinical symptoms and possibilities of CHD diagnosis in the presence of intact coronary arteries have been evaluated in 67 coronary patients, the coronarograms being normal in 46 of those. The diagnosis of CHD was verified by means of various instrumental methods, including electrocardiographic tests and myocardial metabolic studies in conditions of frequent atrial stimulations. The results were computerized, using a specifically designed programme. Sets of signs identifying coronary patients with intact coronary arteries at questioning and noninvasive investigation are presented.

[Use of peripheral vasodilators and beta-adrenergic blockaders in the acute period of myocardial infarction (hemodynamic and metabolic aspects)]. / Primenenie perifericheskikh vazodilatatorov i beta-adrenergicheskikh blokatorov v ostrom periode infarkta miokarda (gemodinamicheskie i metabolicheskie aspekty).

The paper reports hemodynamic and biochemical findings in 76 patients with acute myocardial infarction on the basis of which the patients were treated with either peripheral vasodilators (sodium nitroprusside) or beta-blockers (obsidan). Changes in hemodynamic patterns and myocardial metabolism in response to treatment are described. It is concluded that careful hemodynamic and metabolic monitoring is essential in the management of acute myocardial infarction, particularly, where agents affecting the spread of necrotic areas are administered.

[Prostaglandins A1, E1 and F2 alpha concentrations in the arterial and coronary venous blood of patients with ischemic heart disease during induced myocardial ischemia]. / Soderzhanie prostaglandinov A1, E1, F2 alpha v arterial'noi i koronarnoi venoznoi krovi u bol'nykh ishemicheskoi bolezn'iu serdtsa pri indutsirovannoi ishemii miokarda.

Prostaglandins (PGA1, PGE1 and PGF2 alpha) were assayed in 15 patients with chronic coronary disease during an anginal attack induced through frequent atrial stimulation. Measurements from eleven patients with intact coronary arteries served as control. Lactate extraction coefficient was used as a biochemical indicator of myocardial ischemia; the latter was associated with increased production of coronary sinus PGF2 alpha and arterial PGA1. No correlation could be established between PG levels in the studied series, the extent of ST depression on electrocardiograms, lactate extraction level and hemodynamic manifestations.

[Clinical instrumental diagnosis of ischemic heart disease in patients with unaltered coronary arteries]. / Kliniko-instrumental'naia diagnostika ishemicheskoi bolezni serdtsa u bol'nykh s neizmenennymi koronarnymi arteriiami.

In 16 patients with unchanged coronary arteries during coronaroangiography, where ischaemic heart disease was suspected, the use of bicycle ergometry and studies of the myocardium metabolism with the atrial stimulation test it was possible to diagnose myocardial ischaemia during the pain attack. It must be noted that atypical forms of angina pectoris are frequent. Patients with unchanged coronaroangiogram must have myocardium metabolism examined during the pain attack in order to exclude finally ischaemic heart disease.

[Parameters of myocardial metabolism and central hemodynamics in acute myocardial infarct]. / Issledovanie nekotorykh parametrov metabolizma miokarda i tsentral'noi gemodinamiki u bol'nykh ostrym infarktom miokarda.

The study in 15 patients with myocardial infarction of the content in the arterial blood and the blood of the coronary sinus of lactate, glucose, nonesterified fatty acids has shown the increase of utilization of these substances in 5 cases, appearance of lactate production and enhancement of glucose and insulin extraction in 4, decrease of extraction of glucose, lactate, insulin in 4 patients. In the complicated cases of myocardial infarction it was established that the extraction of glucose, insulin decrease and in a number of cased production of lactate by the myocardium supervenes. It is concluded that interrelationship exists between the type of metabolic disorders and the frequency of complications in myocardial infarction.

[Characteristics of anginal pains in chronic ischemic heart disease]. / Osobennosti anginoznykh bolei pri khronicheskoi ishemicheskoi bolezni serdtsa.

A special questionnaire chart was used to analyse the "structure" of the cardiac pain syndrome in 77 patients with ischaemic heart disease and atypical pains: protracted attacks were recorded in 53 (out of them 13 had Prinzmetall angina pectoris), 11 had attacks with a vegetative crisis background. In 6 patients localization of pains was atypical, in 15 the pains bore the character of cardialgia. To avoid diagnostic errors the physician must analyze thoroughly subjective feelings of the patient with pains in the heart.