Subject(s)
Labor, Obstetric , Ranitidine/therapeutic use , Female , Gastrointestinal Contents , Humans , Hydrogen-Ion Concentration , PregnancyABSTRACT
The rate of gastric emptying was studied in 30 women during labour. All the women had received pethidine 100 mg i.m. for analgesia and, subsequently, extradural analgesia had been established for obstetric indications. The women were allocated randomly to two groups: 15 received naloxone 1.2 mg i.v. and 15 were given saline 3 ml (placebo). All 30 patients were then given paracetamol 1.5 g orally with water 100 ml. The amount of paracetamol absorbed, and hence gastric emptying, was significantly greater in the naloxone group in the first 30 min following the administration of the paracetamol.
Subject(s)
Gastric Emptying/drug effects , Labor, Obstetric , Naloxone/pharmacology , Acetaminophen/metabolism , Adult , Analgesia , Anesthesia, Epidural , Anesthesia, Obstetrical , Female , Humans , Intestinal Absorption , Meperidine , Pregnancy , Time FactorsSubject(s)
Anesthesia, Inhalation/methods , Anesthetics/analysis , Humans , Nitrogen , Nitrous Oxide , Oxygen , VolatilizationABSTRACT
Using audiovisual reaction times, no effects were found in 12 subjects exposed to 1, 2, 4, or 8% nitrous oxide. In subsequent studies on 30 subjects, a positive effect on performance was found at a concentration of between 8 and 12% nitrous oxide. In addition, there was no difference in mean reaction time in 12 subjects exposed to air or 8% nitrous oxide. It is concluded that the threshold concentration of nitrous oxide for an effect on psychomotor performance as assessed by choice reaction times probably lies between 8 and 12%.
