ABSTRACT
We report for the first time the preparation of a fibrous material composed of surface grafted spherical nanosilver and collagen using one-step electrospinning. The resulting composite showed comparable morphology to the control without nanosilver, but had improved electrical conductivity. Under electrical stimulation, fibrous materials containing nanosilver increased connexin-43 expression and proliferation of neonatal cardiomyocytes. Furthermore, composites containing nanosilver prevented biofilm formation but did not activate macrophages.
ABSTRACT
An efficient synthetic route to the resveratrol oligomers quadrangularinâ A and pallidol is reported. It features a scalable biomimetic oxidative dimerization that proceeds in excellent yield and with complete regioselectivity. A systematic evaluation of the natural products and their synthetic precursors as radical-trapping antioxidants has revealed that, contrary to popular belief, this mode of action is unlikely to account for their observed biological activity.