Mirtazapine treatment and sexual functions: Results of a Hungarian, multicentre, prospective study in depressed out-patients.

Since many antidepressants can cause sexual dysfunction, the aim of this study was to follow-up sexual functions during mirtazapine (RemeronSolTab®) treatment. One hundred and two (44 male and 58 female) outpatients with major depression were recruited to this prospective, observational, non-interventional study. The screening was followed by three visits, during which the 17-HAMD, CGI and 9-BDI scales were used. The change of sexual life was monitored by a self-completing questionnaire, based on the modified Psychotropic-Related Sexual Dysfunction Questionnaire. During the treatment both the depression rating scales and the CGI have shown a significant improvement and significant amelioration of previous sexual problems was found; patients were evaluating their sexual life better and better. Our results indicated that mirtazapine is an effective tool for depressed patients who suffer from sexual dysfunction.

[Effects of mirtazapine in patients with chronic tension-type headache. Literature review]. / A mirtazapin hatása a krónikus tenziós típusú fejfájásban szenvedõ betegekre. Irodalmi attekintés.

On the basis of the criteria of the International Headache Society (IHS) tension-type headache (TTH) is classed among the primary headaches. The independent headache diseases are characterized with the type of headache and with the concomitant symptoms. Among the independent headaches TTH has the highest prevalence (38.3%). The prevalence which is the highest between the age of 30 and 39, in women is higher (46,9%) than is men (42.3%). The diagnosis of TTH is not automatically mean the diagnosis of depression. Depression can occur as a comorbid disease. In episodic TTH the prevalence of depression is 32%, while in chronic TTH it is 40%. The prophylactic treatment of patients suffering from chronic TTH has not been solved yet. On the basis of a double-blind, placebo-controlled study mirtazapine is said to be a good opportunity in the treatment of patients with chronic TTH, as it improved the status of the patients with 34% (AUC: Area Under the headache Curve calculated from the product of the period and the intensity of headache), moreover mirtazapine decreased the frequency, intensity and duration of headache as well. The favourable effects of mirtazapine is explained beyond its serotonergic and noradrenergic dual mode of action with its antinociceptive effects which is presumably fulfilled via 3-opioid receptors.

[Changes in sexual function in mirtazapine treatment. Primary data of a national, multicenter, prospective observational study in depressed patients]. / A szexuális funkciók alakulása mirtazapin kezelés során. Depressziós páciensek körében végzett hazai, multicentrikus, prospektív vizsgálat elso eredményei.

INTRODUCTION AND OBJECT: It is a well-known fact, that in most of the psychiatric diseases problems can break out on the field of sexual life as well, which frequently occurs particularly in depression. The problems can be even worse, because of the side effects of the antidepressants causing sexual dysfunction. Nowadays there are some new antidepressants, which have more favourable side effect profiles. The aim of this study was to follow up the occuring side effects during mirtazapine treatment with special regard to incidence of sexual problems. PATIENTS AND METHOD: Altogether 102 outpatients (44 men, 58 women) were recruited to this prospective, observational, non-interventional study, who were suffering from depression and had stable partner, permanent sexual life and who signed the informed consent. The screening was followed by three visits, when the 17-HAMD, CGI and 9-BDI scales were used. The change of sexual life was monitored by a self- completing questionnaire. RESULTS AND CONCLUSION: Both the depression rating scales and the CGI have shown a significant mood improvement. From monitoring the changes in sexual life it turned out, that patients reported sexual problems much rarer as they had done it at the beginning of the study (screening: 93.2%, one month later 61%, three months later 27.1%, at the end of the study only 24.6%) Patients were evaluating their sexual life better and better during the study, and parallel to this, frequency of sexual intercourse was also increased. On the basis of the results it can be established, that mirtazapine is an effective tool for even those depressed patients who suffer from sexual dysfunction. Together with curing the depression and improving the sexual life mirtazapine can also help to restore the good quality of life.

[Review of antidepressants from the TCAs to the third generation drugs]. / Az antidepresszívumok áttekintése a TCA-któl a harmadik generációs szerekig.

Standpoints regarding the pathomechanism of unipolar major depressive disorder (MDD) and the relevant pharmaco-therapeutical possibilities are discussed in the paper. Generations of the antidepressants from the tri- and teracyclic drugs (TCAs) to the modern, dual-acting antidepressants, including the still popular selective serotonin reuptake inhibitors (SSRIs) are surveyed in more detailed. Pharmacodynamic properties of each antidepressant subgroup with the therapeutical benefits, the occasional side-effects and with some characteristic features of the detailed ingredients in certain cases are emphasized. Some benefits and possible disadvantages regarding the combinations are also discussed briefly. The main aim of this review is to give an objective approach to the psychiatrists in order to choose the best and optimal pharmaco-therapeutical method in their daily practice.

[The multidrug resistance modulators heterocondensed quinazolones]. / Multidrug rezisztencia gátló heterokondenzált kinazolonok szintézise.

Exploration for new MDR-modulators utilizing pyrazino[2,1-b]quinazolones as scaffolds disclosed after systematic synthetic investigation highly hydrophobic N-substituted derivatives as a readily accessible active tricyclic compounds. A versatile synthesis of 2-substituted-1,2,3,4-tetrahydro-6H-pyrazino[2,1-b]quinazoline-3,6-diones is presented starting from 2,3-substituted quinazolines. The new compounds have been characterized by elemental analyses, 1H nmr and in some cases by 13C ruler, and X-ray investigations.