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J Neurol Sci ; 222(1-2): 35-8, 2004 Jul 15.
Article in English | MEDLINE | ID: mdl-15240193

ABSTRACT

HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy characterized by a slowly progressive spastic paraparesis and sphincter disturbances beginning in adulthood. Only eight well-documented cases occurring in childhood and adolescence have been described. Infective dermatitis associated to the HTLV-I (IDH) is a chronic eczema of childhood occurring in vertically infected carriers. Here we describe a 7-year-old boy with HAM/TSP and IDH. The neurological manifestations were spastic gait, hyperreflexia of lower limbs, clonus and bilateral Babinski's sign. High levels of HTLV-I antibodies in the serum and in the cerebrospinal fluid were observed. The association of these two diseases and the early onset of HAM/TSP are probably related to a strong humoral anti-HTLV-I response.


Subject(s)
Eczema/diagnosis , Eczema/immunology , Paraparesis, Tropical Spastic/diagnosis , Paraparesis, Tropical Spastic/immunology , Antibodies, Viral/blood , Antibodies, Viral/cerebrospinal fluid , Antibody Formation/immunology , Autoimmune Diseases/diagnosis , Autoimmune Diseases/immunology , Autoimmune Diseases/virology , Causality , Chemotaxis, Leukocyte/immunology , Child , Eczema/virology , Human T-lymphotropic virus 1/immunology , Humans , Male , Muscle Spasticity/immunology , Muscle Spasticity/physiopathology , Paraparesis, Tropical Spastic/virology , Reflex, Babinski/immunology , Reflex, Babinski/physiopathology , Skin/immunology , Skin/pathology , Skin/physiopathology
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