Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Nutr J ; 15: 19, 2016 Feb 27.
Article in English | MEDLINE | ID: mdl-26920136

ABSTRACT

BACKGROUND: Nutrients such as docosahexaenoic acid (DHA), prebiotics and ß-glucan have been associated with reduced incidence of respiratory illnesses and allergic manifestations (AM). Our objective was to assess if consumption of a cow's milk-based beverage with these and other nutrients supports respiratory, gastrointestinal, and skin health in otherwise well-nourished, healthy children. METHODS: In this double-blind, randomized, controlled trial, healthy children (1-4 years of age) from two daycare centers in Brazil were fed three servings/day of a cow's milk-based beverage (CMBB; n = 125) containing DHA, the prebiotics polydextrose (PDX) and galactooligosaccharides (GOS), ß-glucan, and other key nutrients, or a control cow's milk-based beverage (control; n = 131) for up to 28 weeks. Occurrence of respiratory infections, diarrheal disease and AM was assessed by study pediatricians and the number of episodes were analyzed with the Cochran-Mantel-Haenszel test and the Andersen-Gill model. RESULTS: The CMBB group had fewer episodes of AM, which included allergic rhinitis or conjunctivitis, wheezing, allergic cough, eczema and urticaria, compared to the control group (p = 0.021). The hazard ratio for increased number of episodes of AM was lower in the CMBB group compared to control (HR, 0.64; 95 % CI 0.47-0.89; p = 0.007). There was no difference in the incidence of respiratory infections and diarrheal disease between groups. CONCLUSION: A cow's milk-based beverage containing DHA, PDX/GOS, and yeast ß-glucan, and supplemented with micronutrients, including zinc, vitamin A and iron, when consumed 3 times/day for 28 weeks by healthy 1- to 4-year-old children was associated with fewer episodes of allergic manifestations in the skin and the respiratory tract. TRIAL REGISTRATION: registration number: NCT01431469.


Subject(s)
Beverages , Diarrhea/epidemiology , Hypersensitivity/epidemiology , Milk , Respiratory Tract Infections/epidemiology , Animals , Biomarkers/blood , Brazil , Child, Preschool , Dietary Supplements , Docosahexaenoic Acids/administration & dosage , Docosahexaenoic Acids/analysis , Double-Blind Method , Female , Follow-Up Studies , Humans , Incidence , Infant , Interleukin-10/blood , Male , Micronutrients/administration & dosage , Prebiotics/administration & dosage , Prospective Studies , Socioeconomic Factors , Transforming Growth Factor beta1/blood , Treatment Outcome , Trisaccharides/administration & dosage , Trisaccharides/analysis , beta-Glucans/administration & dosage , beta-Glucans/analysis
SELECTION OF CITATIONS
SEARCH DETAIL
...