Subject(s)
Humans , Female , Adolescent , Adult , Young Adult , Genitalia, Female , Genitalia, Female/abnormalities , Genitalia, Male , Genitalia, Male/abnormalitiesSubject(s)
Adolescent , Adult , Young Adult , Congenital Abnormalities , Therapeutics , Classification , Diagnosis , BreastABSTRACT
OBJECTIVES: To investigate three genes associated with puberty timing in girls with central precocious puberty by evaluating the association between polymorphism in the gene sequence codifying the enzymes participating in steroidogenesis, CYP1A1, CYP17, and CYP1B1 and central precocious puberty. STUDY DESIGN: A total of 177 patients was included and divided into two groups: Case group with 73 girls diagnosed with central precocious puberty; Control group with 104 girls with puberty onset after 8 years of age who were followed at the Sector of Gynecology of Childhood and Adolescence, Division of Gynecology Clinic, HC-FMUSP. Polymorphism presence was assessed in the genes involved in estrogen metabolism (CYP1A1, CYP17, and CYP1B1) by the restriction fragment length polymorphism (RFLP) technique using DNA from peripheral blood. RESULTS: No significant difference in the distribution of the CYP1A1 Mspl (p=0.86) and CYP17 (p=0.12) genotypes was detected between the two study groups. As for CYP1B1 Eco571, the mutated C/C genotype was found to be more frequent in the control group than in the case group (p=0.03). CONCLUSION: Our data suggest the CYP1B1 Eco571 gene variant is associated with puberty timing.
Subject(s)
Cytochrome P-450 CYP1A1/genetics , Cytochrome P-450 CYP1B1/genetics , Puberty, Precocious/genetics , Steroid 17-alpha-Hydroxylase/genetics , Adolescent , Case-Control Studies , Child , Child, Preschool , Female , Genotype , Humans , Menarche/genetics , Mutation , Pilot Projects , Polymorphism, Restriction Fragment LengthABSTRACT
We present the case of a 19-year-old nulligravida woman with severe dysmenorrhea since menarche; she was found to have a longitudinal vaginal septum, cervical duplication and two endometrial cavities, separated by a complete septum. Diagnosis and management of this unusual Müllerian anomaly are discussed in the context of a literature review.
Subject(s)
Cervix Uteri/abnormalities , Uterus/abnormalities , Vagina/abnormalities , Cervix Uteri/surgery , Female , Humans , Hysteroscopy , Uterus/surgery , Vagina/surgery , Young AdultABSTRACT
We present the case of a 19-year-old nulligravida woman with severe dysmenorrhea since menarche; she was found to have a longitudinal vaginal septum, cervical duplication and two endometrial cavities, separated by a complete septum. Diagnosis and management of this unusual Müllerian anomaly are discussed in the context of a literature review.
No presente artigo, relata-se o caso de uma mulher de 19 anos com queixa de dismenorreia intensa desde a menarca. Diagnosticou-se a presença de septo longitudinal vaginal, duplicidade cervical e duas cavidades endometriais, separadas por um septo completo. O diagnóstico e o manejo desta rara malformação Mülleriana são discutidos junto a uma revisão bibliográfica.
Subject(s)
Female , Humans , Young Adult , Cervix Uteri/abnormalities , Uterus/abnormalities , Vagina/abnormalities , Cervix Uteri/surgery , Hysteroscopy , Uterus/surgery , Vagina/surgeryABSTRACT
The aim of this paper was to discuss the embryological aspects of Müllerian duct anomalies and to analyze the current diagnostic methods and therapy. Müllerian anomalies are congenital defects of the female reproductive tract resulting from failure in the development of the Müllerian ducts and their associated structures. Their cause has yet to be fully clarified, and it is currently believed to be multifactorial. Symptoms appear principally during adolescence or early adulthood, and affect the reproductive capacity of these women. When clinically suspected, investigations leading to diagnosis include imaging methods such as hysterosalpingography, ultrasonography and magnetic resonance. The classification of these malformations relates to their embryogenesis, and defines the therapy and prognosis. Müllerian anomalies consist of a wide range of defects that may vary from patient to patient. Therefore, their management must also be individual, taking anatomical and clinical characteristics into consideration, as well as the patient's wishes.
Subject(s)
Mullerian Ducts/abnormalities , Urogenital Abnormalities/therapy , Adolescent , Adult , Female , Humans , Infertility, Female , Mullerian Ducts/embryology , Urogenital Abnormalities/classification , Urogenital Abnormalities/diagnosis , Young AdultABSTRACT
The aim of this paper was to discuss the embryological aspects of Müllerian duct anomalies and to analyze the current diagnostic methods and therapy. Müllerian anomalies are congenital defects of the female reproductive tract resulting from failure in the development of the Müllerian ducts and their associated structures. Their cause has yet to be fully clarified, and it is currently believed to be multifactorial. Symptoms appear principally during adolescence or early adulthood, and affect the reproductive capacity of these women. When clinically suspected, investigations leading to diagnosis include imaging methods such as hysterosalpingography, ultrasonography and magnetic resonance. The classification of these malformations relates to their embryogenesis, and defines the therapy and prognosis. Müllerian anomalies consist of a wide range of defects that may vary from patient to patient. Therefore, their management must also be individual, taking anatomical and clinical characteristics into consideration, as well as the patient's wishes.
O objetivo deste trabalho foi discutir as malformações müllerianas desde seus aspectos embriológicos, analisando os atuais métodos diagnóstico e terapêuticos. As malformações müllerianas são anomalias congênitas do trato reprodutivo feminino decorrentes de falha do desenvolvimento dos ductos de Müller e estruturas associadas. Sua causa não foi completamente elucidada, acreditando-se, atualmente, que seja multifatorial. Os sintomas se manifestam, principalmente, durante a adolescência e início da vida adulta, e afetam a capacidade reprodutiva dessas mulheres. A partir da suspeita clínica, a investigação diagnóstica inclui métodos de imagem, como a histerosalpingografia, ultrassonografia e ressonância magnética. A classificação das malformações está relacionada à sua embriogênese e direciona a terapêutica e prognóstico. As malformações müllerianas são um grupo amplo de anomalias que variam de paciente para paciente. Portanto, sua abordagem também é individual, devendo-se considerar os aspectos anatômicos, clínicos e o desejo da paciente.
Subject(s)
Adolescent , Adult , Female , Humans , Young Adult , Mullerian Ducts/abnormalities , Urogenital Abnormalities/therapy , Infertility, Female , Mullerian Ducts/embryology , Urogenital Abnormalities/classification , Urogenital Abnormalities/diagnosis , Young AdultABSTRACT
INTRODUCTION: This study compared two regimens of a monthly injectable contraceptive containing dihydroxyprogesterone acetophenide 150 mg and estradiol enanthate 10 mg (Perlutan) over 12 cycles of use. METHODS: Three hundred sixty-five adolescents were randomized into two groups. The patients in Group 1 received an initial injection of Perlutan on the 1st-5th day of their menstrual cycle and subsequent injections every 30 +/- 3 days, whereas those in Group 2 followed the traditional schedule of administration in which the first injection is administered between Days 7 and 10 of their menstrual cycle and subsequent injections 7-10 days after Day 1 of withdrawal bleeding. This schedule may result in an irregularity in the timing of injections. RESULTS: No significant difference was found between the two groups regarding tolerability or pregnancy (two in Group 1 and three in Group 2). CONCLUSION: Monthly administration limits the annual number of injections to a maximum of 12, thus frequently reducing the total annual dose while maintaining efficacy and tolerability similar to those obtained with the traditional regimen.
Subject(s)
Algestone Acetophenide/administration & dosage , Contraceptives, Oral, Combined/administration & dosage , Estradiol/analogs & derivatives , Adolescent , Brazil , Drug Administration Schedule , Estradiol/administration & dosage , Female , Humans , InjectionsSubject(s)
Humans , Female , Infant , Child, Preschool , Child , Adolescent , Candidiasis, Vulvovaginal/etiology , Trichomonas Vaginitis , Vaginitis , Vulvitis/etiology , Anti-Bacterial Agents/therapeutic use , Diabetes Mellitus/complications , Enterobius/parasitology , Syphilis/complications , Vaginitis/drug therapy , Vulva/anatomy & histologyABSTRACT
Foram analisados 10 casos de distrofia vulvar crônica em pacientes até nove anos de idade. Prurido vulvar foi o sintoma mais freqüente nos casos examinados. Todas as pacientes foram submetidas a biópsia vulvar (punch biopsy¿ sob anestesia local, no ambulatório. O diagnóstico histopatológico revelou sete casos de líquen escleroso, dois casos de distrofia hiperplásica e um caso de distrofia mista. Em nenhum corte histológico foram encontradas atipias celulares
Subject(s)
Child, Preschool , Child , Humans , Male , Female , Vulvar Diseases/pathology , Pruritus Vulvae/pathology , Chronic DiseaseABSTRACT
Os autores analisam 80 casos de aderência dos lábios menores do pudendo em meninas até 12 anos de idade. Consideram que a etiologia é inflamatória e assinalam as intercorrências clínicas advindas da aderência parcial e total: vulvovaginite, dificuldade de micçäo e disúria. Apresentam o plano terapêutico adotado: aplicaçäo tópica de creme de estrogênios. Consideram sem importância clínica os efeitos colaterais observados. Os resultados obtidos foram bons em 82,5% dos casos analisados
