Subject(s)
Foot Diseases/diagnosis , Neurofibrosarcoma/diagnosis , Skin Neoplasms/diagnosis , Biomarkers, Tumor/analysis , Diagnosis, Differential , Foot Diseases/pathology , Foot Diseases/surgery , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neoplasm Invasiveness , Neurofibrosarcoma/pathology , Skin/pathology , Skin Neoplasms/pathology , Skin Neoplasms/surgeryABSTRACT
Proliferative nodules can occasionally arise on congenital and acquired melanocytic nevi. At first sight their clinical and pathologic features cause alert to both dermatologist and dermatopathologist. However, proliferative nodules are typically benign, regression is common and there is minimum risk of malignization. We present a new case of proliferative nodule in melanocytic nevi with features of deep penetrating nevus.
Subject(s)
Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Adult , Diagnosis, Differential , Female , Humans , Melanoma/pathology , Nevus/pathologyABSTRACT
Abstract: Proliferative nodules can occasionally arise on congenital and acquired melanocytic nevi. At first sight their clinical and pathologic features cause alert to both dermatologist and dermatopathologist. However, proliferative nodules are typically benign, regression is common and there is minimum risk of malignization. We present a new case of proliferative nodule in melanocytic nevi with features of deep penetrating nevus.
Subject(s)
Humans , Female , Adult , Skin Neoplasms/pathology , Nevus, Pigmented/pathology , Diagnosis, Differential , Melanoma/pathology , Nevus/pathologyABSTRACT
Recent studies have shown that psoriasis is associated with an increased prevalence of erectile dysfunction. To our knowledge, no comparative study has considered simultaneously the role of organic factors and psychological factors in this process. We performed a prospective case series study matched by age to explore the prevalence of erectile dysfunction in psoriasis patients compared to a healthy population and to investigate the role of anxiety, depression, and cardiovascular risk factors in the relationship between psoriasis and erectile dysfunction. The healthy group was matched by frequency to cases by age. Seventy-nine patients with moderate to severe psoriasis and 79 healthy controls participated in the study. Participants completed the Massachusetts General Hospital Sexual Functioning Questionnaire and the Hospital Anxiety and Depression Scale. Psoriasis patients had an increased prevalence of erectile dysfunction in comparison to controls, 34.2 vs. 17.7 % (p < .05). Multivariate analysis showed a significant association between erectile dysfunction and age, smoking and anxiety/depression, but not with psoriasis per se. In conclusion, the higher prevalence of smoking and anxiety/depression among patients with moderate to severe psoriasis probably explains the higher prevalence of erectile dysfunction in this population.
Subject(s)
Erectile Dysfunction/epidemiology , Psoriasis/complications , Adult , Anxiety , Cardiovascular Diseases/complications , Depression , Erectile Dysfunction/complications , Erectile Dysfunction/psychology , Humans , Male , Middle Aged , Multivariate Analysis , Prevalence , Prospective Studies , Psoriasis/psychology , Risk Factors , Smoking/adverse effectsSubject(s)
Ki-1 Antigen/immunology , Lymphoma, T-Cell, Cutaneous/pathology , Skin/pathology , Biopsy, Needle , Combined Modality Therapy , Follow-Up Studies , Humans , Immunohistochemistry , Lower Extremity , Lymphoma, T-Cell, Cutaneous/diagnosis , Lymphoma, T-Cell, Cutaneous/therapy , Male , Methotrexate/administration & dosage , Middle Aged , Risk Assessment , Treatment Outcome , Ultraviolet Therapy/methodsABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Pigmentation , Skin Pigmentation , Minocycline/adverse effects , Drug-Related Side Effects and Adverse Reactions/complications , Drug-Related Side Effects and Adverse Reactions/diagnosis , Drug-Related Side Effects and Adverse Reactions/prevention & control , Nail Diseases/chemically induced , Nail Diseases/complications , Conjunctiva , Conjunctiva/pathology , Conjunctival Diseases/chemically induced , Sclera , Sclera/pathology , Mouth Mucosa , Thyroid Gland/pathologySubject(s)
Arthritis, Infectious/drug therapy , Hyperpigmentation/chemically induced , Minocycline/adverse effects , Arthritis, Infectious/etiology , Arthritis, Rheumatoid/complications , Denosumab/therapeutic use , Drug Therapy, Combination , Female , Humans , Kidney Failure, Chronic/complications , Melanosis/chemically induced , Middle Aged , Minocycline/therapeutic use , Prednisone/therapeutic useABSTRACT
Palmoplantar lichen planus is a localized and rare subtype of lichen planus (LP) often underdiagnosed. Several morphological types of palmoplantar lesions have been defined in LP. We present an unusual case of the palmoplantar kyperkeratotic variant of LP. Histopathology examination confirmed our diagnosis. We emphasize the importance of this rare entity in the differential diagnosis of palmoplantar dermatoses.
Subject(s)
Foot Dermatoses/diagnosis , Hand Dermatoses/diagnosis , Keratoderma, Palmoplantar/diagnosis , Lichen Planus/diagnosis , Diagnosis, Differential , Foot Dermatoses/etiology , Hand Dermatoses/etiology , Humans , Keratoderma, Palmoplantar/etiology , Lichen Planus/complications , Male , Middle AgedABSTRACT
BACKGROUND: Psoriasis may significantly impair sexual function. Depression and organic factors appear to play a key role in this relation. However, beyond genital psoriasis, the importance of the disease's distribution patterns has not been considered. OBJECTIVES: To research sexual function in psoriasis patients and investigate the roles of anxiety, depression and psoriasis' distribution patterns in sexual dysfunction. METHODS: A comparative study matched for sex and age was performed. Eighty patients with moderate to severe psoriasis and 80 healthy controls were included. The participants completed the Massachusetts General Hospital-Sexual Functioning Questionnaire, the Hospital Anxiety and Depression Scale, and the Self-Administered Psoriasis Area and Severity Index. RESULTS: Psoriasis was associated with sexual dysfunction, odds ratio=5.5 (CI 95% 2.6-11.3; p<0.001). Certain distribution patterns of psoriasis, involving specific body regions, were associated with an increase in sexual dysfunction in the group presenting the disease, odds ratio 7.9 (CI 95% 2.3-33.4; p<0.001). Multivariate logistic regression analysis identified anxiety and depression, and the involvement of these specific areas, as possible independent risk factors for sexual dysfunction in patients with moderate to severe psoriasis. CONCLUSION: This study identifies body areas potentially related to sexual dysfunction, independently of anxiety and depression, in psoriasis patients. The results suggest that the assessment of sexual dysfunction and the involvement of these body areas should be considered as disease severity criteria when choosing the treatment for psoriasis patients.
Subject(s)
Anxiety/psychology , Depression/psychology , Psoriasis/psychology , Sexual Dysfunctions, Psychological/psychology , Adult , Body Image/psychology , Case-Control Studies , Female , Humans , Male , Middle Aged , Severity of Illness Index , Sexual Dysfunctions, Psychological/etiology , Statistics, Nonparametric , Surveys and Questionnaires , Test Anxiety ScaleABSTRACT
Abstract BACKGROUND: Psoriasis may significantly impair sexual function. Depression and organic factors appear to play a key role in this relation. However, beyond genital psoriasis, the importance of the disease's distribution patterns has not been considered. OBJECTIVES: To research sexual function in psoriasis patients and investigate the roles of anxiety, depression and psoriasis' distribution patterns in sexual dysfunction. METHODS: A comparative study matched for sex and age was performed. Eighty patients with moderate to severe psoriasis and 80 healthy controls were included. The participants completed the Massachusetts General Hospital-Sexual Functioning Questionnaire, the Hospital Anxiety and Depression Scale, and the Self-Administered Psoriasis Area and Severity Index. RESULTS: Psoriasis was associated with sexual dysfunction, odds ratio=5.5 (CI 95% 2.6-11.3; p<0.001). Certain distribution patterns of psoriasis, involving specific body regions, were associated with an increase in sexual dysfunction in the group presenting the disease, odds ratio 7.9 (CI 95% 2.3-33.4; p<0.001). Multivariate logistic regression analysis identified anxiety and depression, and the involvement of these specific areas, as possible independent risk factors for sexual dysfunction in patients with moderate to severe psoriasis. CONCLUSION: This study identifies body areas potentially related to sexual dysfunction, independently of anxiety and depression, in psoriasis patients. The results suggest that the assessment of sexual dysfunction and the involvement of these body areas should be considered as disease severity criteria when choosing the treatment for psoriasis patients. .
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Anxiety/psychology , Depression/psychology , Psoriasis/psychology , Sexual Dysfunctions, Psychological/psychology , Body Image/psychology , Case-Control Studies , Severity of Illness Index , Statistics, Nonparametric , Surveys and Questionnaires , Sexual Dysfunctions, Psychological/etiology , Test Anxiety ScaleABSTRACT
INTRODUCTION: Psoriasis may significantly impair sexual function. Depression and organic factors appear to play a key role in this relationship. However, beyond genital psoriasis, the importance of the distribution pattern of the disease has not been considered. AIM: To investigate the role of the distribution pattern of psoriasis in sexual dysfunction. METHODS: A prospective case series study was carried out on 133 patients with moderate to severe psoriasis. MAIN OUTCOME MEASURES: The participants completed the Massachusetts General Hospital-Sexual Functioning Questionnaire, the Hospital Anxiety and Depression Scale, and the Self-Administered Psoriasis Area and Severity Index. RESULTS: Forty-four women (mean age 42.0 ± 14.1) and 79 men (mean age 47 ± 11.7) were included in the study. Psoriasis lesions on abdomen, genitals, lumbar region, and buttocks in women and chest, genitals, and buttocks in men were associated with an increase in sexual dysfunction. Multivariate logistic regression analysis showed that the involvement of these specific areas may be independent risk factors for sexual dysfunction in patients with moderate to severe psoriasis. CONCLUSIONS: This is the first study identifying body areas other than genitals as potentially related to sexual dysfunction in psoriasis patients. The results suggest that the assessment of sexual dysfunction and the involvement of these body areas should be considered as disease severity criteria when deciding on treatment for psoriasis patients.
Subject(s)
Genital Diseases, Female/psychology , Genital Diseases, Male/psychology , Psoriasis/psychology , Self Concept , Severity of Illness Index , Sexual Dysfunctions, Psychological/psychology , Adult , Aged , Anxiety/etiology , Body Image , Depression/etiology , Female , Genital Diseases, Female/complications , Genital Diseases, Male/complications , Humans , Male , Middle Aged , Prospective Studies , Psoriasis/complications , Sexual Dysfunctions, Psychological/etiology , Surveys and QuestionnairesABSTRACT
Granular cell tumour is a rare tumour of neural origin usually located on the face and the neck. The biological behaviour is usually benign. However, certain clinical and histopathological features should alert physicians to a malignant behaviour. This case report describes the occurrence of a granular cell tumour in the inguinal area that resembled a malignant tumour. The histopathological study revealed typical features of granular cell tumour and an extension study confirmed the absence of metastasis. This case highlights the importance of considering this disorder in the differential diagnosis of ulcerated nodules and of managing atypical granular cell tumor appropriately.
Subject(s)
Granular Cell Tumor/pathology , Skin Neoplasms/pathology , Female , Groin , Humans , Middle Aged , Skin Ulcer/pathologyABSTRACT
Granular cell tumour is a rare tumour of neural origin usually located on the face and the neck. The biological behaviour is usually benign. However, certain clinical and histopathological features should alert physicians to a malignant behaviour. This case report describes the occurrence of a granular cell tumour in the inguinal area that resembled a malignant tumour. The histopathological study revealed typical features of granular cell tumour and an extension study confirmed the absence of metastasis. This case highlights the importance of considering this disorder in the differential diagnosis of ulcerated nodules and of managing atypical granular cell tumor appropriately.
Subject(s)
Humans , Female , Middle Aged , Skin Neoplasms/pathology , Granular Cell Tumor/pathology , Skin Ulcer/pathology , GroinABSTRACT
OBJECTIVE: We present a case of eosinophilic pustular folliculitis, a rare dermatosis which is often associated with HIV infection or internal malignancies. CLINICAL PRESENTATION AND INTERVENTION: We report the case of a 66-year-old man with a medical history of hypertension. Histopathological examination showed a dense follicular inflammatory infiltrate with abundant eosinophils. The clinical response to indomethacin was excellent with no recurrence during the follow-up. CONCLUSION: The patient responded well to indomethacin treatment.
