ABSTRACT
Morniflumate is the morpholinoethyl ester of niflumic acid, a non-steroidal anti-inflammatory drug, derived from nicotinic acid. We studied 112 patients who had experienced cutaneous reactions after using non-steroidal anti-inflammatory drugs. Only two of all the patients who underwent an oral challenge with morniflumate had a positive result to the test. By demonstrating the low incidence of reactions to morniflumate through oral challenges, we suggest that patients with non-steroidal anti-inflammatory drug hypersensitivity may tolerate this drug which would therefore be a useful alternative.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Niflumic Acid/analogs & derivatives , Adolescent , Adult , Aged , Aged, 80 and over , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Drug Eruptions/etiology , Female , Humans , Hypersensitivity, Immediate/etiology , Male , Middle Aged , Niflumic Acid/administration & dosage , Young AdultSubject(s)
Allergens/immunology , Antigens, Plant/adverse effects , Food Hypersensitivity/etiology , Mentha/adverse effects , Respiratory Hypersensitivity/etiology , Adult , Allergens/adverse effects , Angioedema , Antigens, Plant/immunology , Antigens, Plant/isolation & purification , Eating , Female , Food Hypersensitivity/diagnosis , Humans , Immunoglobulin E/immunology , Immunoglobulin E/metabolism , Oils, Volatile/adverse effects , Plant Extracts , Plant Leaves/adverse effects , Respiratory Hypersensitivity/diagnosis , Skin TestsABSTRACT
Common drugs in the therapy of chronic idiopathic urticaria (CIU) include antihistamines alone or combined with corticosteroids, but severe unresponsive patients require alternative treatments. This retrospective study aims to evaluate clinical response and safety of low-dose and long-term oral Cyclosporin-A (CyA) in unresponsive patients. One hundred and ten CIU patients, unresponsive to a previous treatment (antihistamines plus prednisone 0.2 mg/kg/day), received additional oral CyA 13 mg/kg/day for 6 months. The patients were subdivided into three groups (A, B, C) according to the different CyA doses. Parameters of clinical efficacy including pruritus, and size and number of wheals were evaluated at baseline, after three and six months. All adverse events were recorded. The mean total symptom severity score decreased by 63% in Group A, 76% in Group B, and 85% in Group C after 6 months. Total disappearance of the symptoms was recorded in 43 patients (39.1%): 7 (28%) of Group A; 12 (37.5%) of Group B and 24 (45%) of Group C. After a mean of 2 months from CyA suspension, 14 patients (11%) had recurrence of symptoms. Minor side effects were noted in 8 patients (7%). Our study indicates that low-dose, long-term CyA therapy is efficacious and safe in severe unresponsive CIU.
Subject(s)
Cyclosporine/therapeutic use , Urticaria/drug therapy , Adult , Aged , Chronic Disease , Cyclosporine/adverse effects , Female , Humans , Male , Middle Aged , Retrospective StudiesSubject(s)
Food Hypersensitivity/diagnosis , Food Hypersensitivity/immunology , Octopodiformes/immunology , Adult , Animals , Female , Humans , Skin TestsABSTRACT
Non-steroidal anti-inflammatory drugs frequently cause adverse reactions. This retrospective study was based on analysis of the data obtained from interviews conducted with 173 patients, who underwent and tolerated a challenge test with etoricoxib (a selective cyclooxigenase 2 enzyme inhibitor). Only one of 82 patients who were treated with etoricoxib reported reactions. We can conclude that etoricoxib shows a high long-term tolerability in patients with non-steroidal anti-inflammatory drug hypersensitivity.
