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1.
Ann Biomed Eng ; 51(10): 2258-2266, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37294414

ABSTRACT

Fracture healing is stimulated by micromotion at the fracture site, whereby there exists an optimal amount of strain to promote secondary bone formation. Surgical plates used for fracture fixation are often evaluated for their biomechanical performance using benchtop studies, where success is based on overall construct stiffness and strength measures. Integration of fracture gap tracking to this assessment would provide crucial information about how plates support the various fragments present in comminuted fractures, to ensure there are appropriate levels of micromotion during early healing. The goal of this study was to configure an optical tracking system to quantify 3D interfragmentary motion to assess the stability (and corresponding healing potential) of comminuted fractures. An optical tracking system (OptiTrack, Natural Point Inc, Corvallis, OR) was mounted to a material testing machine (Instron 1567, Norwood, MA, USA), with an overall marker tracking accuracy of 0.05 mm. Marker clusters were constructed that could be affixed to individual bone fragments, and segment-fixed coordinate systems were developed. The interfragmentary motion was calculated by tracking the segments while under load and was resolved into compression-extraction and shear components. This technique was evaluated using two cadaveric distal tibia-fibula complexes with simulated intra-articular pilon fractures. Normal and shear strains were tracked during cyclic loading (for stiffness tests), and a wedge gap was also tracked to assess failure in an alternate clinically relevant mode. This technique will augment the utility of benchtop fracture studies by moving beyond total construct response and providing anatomically relevant data on interfragmentary motion, a valuable proxy for healing potential.


Subject(s)
Fracture Fixation, Internal , Fractures, Comminuted , Humans , Fractures, Comminuted/surgery , Bone Plates , Fracture Fixation , Fracture Healing , Biomechanical Phenomena
2.
Anaesthesia ; 77(3): 301-310, 2022 Mar.
Article in English | MEDLINE | ID: mdl-34861745

ABSTRACT

Interscalene brachial plexus block is the standard regional analgesic technique for shoulder surgery. Given its adverse effects, alternative techniques have been explored. Reports suggest that the erector spinae plane block may potentially provide effective analgesia following shoulder surgery. However, its analgesic efficacy for shoulder surgery compared with placebo or local anaesthetic infiltration has never been established. We conducted a randomised controlled trial to compare the analgesic efficacy of pre-operative T2 erector spinae plane block with peri-articular infiltration at the end of surgery. Sixty-two patients undergoing arthroscopic shoulder repair were randomly assigned to receive active erector spinae plane block with saline peri-articular injection (n = 31) or active peri-articular injection with saline erector spinae plane block (n = 31) in a blinded double-dummy design. Primary outcome was resting pain score in recovery. Secondary outcomes included pain scores with movement; opioid use; patient satisfaction; adverse effects in hospital; and outcomes at 24 h and 1 month. There was no difference in pain scores in recovery, with a median difference (95%CI) of 0.6 (-1.9-3.1), p = 0.65. Median postoperative oral morphine equivalent utilisation was significantly higher in the erector spinae plane group (21 mg vs. 12 mg; p = 0.028). Itching was observed in 10% of patients who received erector spinae plane block and there was no difference in the incidence of significant nausea and vomiting. Patient satisfaction scores, and pain scores and opioid use at 24 h were similar. At 1 month, six (peri-articular injection) and eight (erector spinae plane block) patients reported persistent pain. Erector spinae plane block was not superior to peri-articular injection for arthroscopic shoulder surgery.


Subject(s)
Arthroscopy/methods , Nerve Block/methods , Pain Management/methods , Pain, Postoperative/prevention & control , Paraspinal Muscles/drug effects , Shoulder Joint/surgery , Adult , Anesthetics, Local/administration & dosage , Arthroscopy/adverse effects , Female , Follow-Up Studies , Humans , Injections, Intra-Articular/methods , Male , Middle Aged , Paraspinal Muscles/diagnostic imaging , Paraspinal Muscles/innervation , Shoulder Joint/diagnostic imaging , Shoulder Joint/drug effects , Ultrasonography, Interventional/methods
3.
Bone Joint J ; 101-B(9): 1107-1114, 2019 09.
Article in English | MEDLINE | ID: mdl-31474140

ABSTRACT

AIMS: The aim of this study was to evaluate the differences in revision and complication rates, functional outcomes, and radiological outcomes between cemented and press-fit humeral stems in primary anatomical total shoulder arthroplasty (TSA). MATERIALS AND METHODS: A comprehensive systematic review and meta-analysis was conducted searching for studies that included patients who underwent primary anatomical TSA for primary osteoarthritis or rheumatoid arthritis. RESULTS: There was a total of 36 studies with 927 cemented humeral stems and 1555 press-fit stems. The revision rate was 5.4% (95% confidence interval (CI) 3.9 to 7.4) at a mean of 89 months for cemented stems, and 2.4% (95% CI 1.1 to 4.7) at a mean of 40 months for press-fit stems. A priori subgroup analysis to control for follow-up periods demonstrated similar revision rates: 2.3% (95% CI 1.1 to 4.7) for cemented stems versus 1.8% (95% CI 1.4 to 2.9) for press-fit stems. Exploratory meta-regression found that longer follow-up was a moderating variable for revision (p = 0.003). CONCLUSION: Cement fixation had similar revision rates when compared to press-fit stems at short- to midterm follow-up. Rotator cuff pathology was a prevalent complication in both groups but is likely not related to fixation type. Overall, with comparable revision rates, possible easier revision, and decreased operative time, humeral press-fit fixation may be an optimal choice for primary anatomical TSA in patients with sufficient bone stock. Cite this article: Bone Joint J 2019;101-B:1107-1114.


Subject(s)
Arthroplasty, Replacement, Shoulder/adverse effects , Arthroplasty, Replacement, Shoulder/methods , Humerus/surgery , Osteoarthritis/surgery , Shoulder Joint/surgery , Shoulder Prosthesis/adverse effects , Bone Cements , Cementation , Humans , Postoperative Complications , Prosthesis Failure , Recovery of Function , Reoperation , Treatment Outcome
4.
Bone Joint J ; 97-B(2): 150-3, 2015 Feb.
Article in English | MEDLINE | ID: mdl-25628274

ABSTRACT

In this study we evaluated whether pre-operative Western Ontario and McMaster Universities (WOMAC) osteoarthritis scores can predict satisfaction following total hip arthroplasty (THA). Prospective data for a cohort of patients undergoing THA from two large academic centres were collected, and pre-operative and one-year post-operative WOMAC scores and a 25-point satisfaction questionnaire were obtained for 446 patients. Satisfaction scores were dichotomised into either improvement or deterioration. Scatter plots and Spearman's rank correlation coefficient were used to describe the association between pre-operative WOMAC and one-year post-operative WOMAC scores and patient satisfaction. Satisfaction was compared using receiver operating characteristic (ROC) analysis against pre-operative, post-operative and δ WOMAC scores. We found no relationship between pre-operative WOMAC scores and one-year post-operative WOMAC or satisfaction scores, with Spearman's rank correlation coefficients of 0.16 and -0.05, respectively. The ROC analysis showed areas under the curve (AUC) of 0.54 (pre-operative WOMAC), 0.67 (post-operative WOMAC) and 0.43 (δ WOMAC), respectively, for an improvement in satisfaction. We conclude that the pre-operative WOMAC score does not predict the post-operative WOMAC score or patient satisfaction after THA, and that WOMAC scores can therefore not be used to prioritise patient care.


Subject(s)
Osteoarthritis, Hip/surgery , Patient Satisfaction , Adult , Aged , Aged, 80 and over , Area Under Curve , Arthroplasty, Replacement, Hip , Female , Health Status Indicators , Humans , Male , Middle Aged , Prospective Studies , ROC Curve
5.
J Biomech ; 46(4): 677-82, 2013 Feb 22.
Article in English | MEDLINE | ID: mdl-23305814

ABSTRACT

BACKGROUND: Investigating joint mechanics is important when determining the etiology of osteoarthritis, as degenerative changes are thought to occur due to altered joint mechanics. The objective of this study was to demonstrate the utility of an x-ray computed tomography-based approach to evaluate joint congruency in the setting of subtle kinematic alterations, employing an in vitro model of collateral ligament repair of the elbow. METHODS: Active and passive elbow flexion was performed in 4 and 5 fresh-frozen cadaveric upper extremities respectively using an elbow motion simulator in the valgus gravity dependent positions. The collateral ligaments were sectioned and repaired. A registration and inter-bone distance algorithm were then used to examine ulnohumeral joint congruency (quantified as surface area) throughout elbow flexion. Valgus angulation was also measured. FINDINGS: Following ligament sectioning and repair, there was a 1.2±1.0° increase in valgus angulation in active flexion and a 21.2±26.2% decrease in surface area. In passive flexion, valgus angulation increased 3.3±2.2° and surface area decreased 57.9±39.9%. INTERPRETATION: The technique described to quantify joint congruency proved to be sensitive enough to detect large changes in joint surface interactions inspite of only small changes in traditionally measured kinematics. These changes in joint congruency may, in part, explain the high incidence of arthritis that has been reported following ligament injuries of the elbow, even in the absence of clinically detectable instability. This technique, when adapted for in vivo use, will be a useful tool to evaluate joint function and the effectiveness of treatments non-invasively.


Subject(s)
Elbow Injuries , Elbow Joint/physiopathology , Aged , Algorithms , Biomechanical Phenomena , Cadaver , Collateral Ligaments/injuries , Collateral Ligaments/physiopathology , Collateral Ligaments/surgery , Elbow Joint/diagnostic imaging , Humans , Joint Instability/physiopathology , Male , Models, Biological , Movement/physiology , Osteoarthritis/etiology , Osteoarthritis/physiopathology , Range of Motion, Articular/physiology , Tomography, X-Ray Computed
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