Search | VHL Regional Portal

Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis.

Ware, Carol B; Kariagina, Anastasia; Zonis, Svetlana; Alon, Dana; Chesnokova, Vera.

FEBS Lett ; 579(20): 4465-9, 2005 Aug 15.

Article in English | MEDLINE | ID: mdl-16081071

ABSTRACT

Leukemia inhibitory factor (LIF) is expressed in the hypothalamic-pituitary adrenal (HPA) axis and stimulates pituitary POMC transcription. The role of LIF receptor signaling in HPA axis development was examined. Lifr -/- and Lifr +/+ fetuses were obtained by Cesarean section on E18.5. Despite a 3-fold induction of hypothalamic CRH mRNA, pituitary POMC mRNA and RU486-induced ACTH levels were decreased in Lifr -/- mice. High CRH may be caused by increased central TNFalpha and IL-6 expression. Lifr -/- mice demonstrate elevated pituitary glucocorticoid (GR) and mineralocorticoid (MR) receptor mRNA and protein levels, indicating the importance of LIF signaling for HPA axis development.

Subject(s)

Hypothalamo-Hypophyseal System/embryology , Pituitary-Adrenal System/embryology , Receptors, Cytokine/physiology , Signal Transduction , Adrenocorticotropic Hormone/analysis , Adrenocorticotropic Hormone/metabolism , Animals , Corticotropin-Releasing Hormone/genetics , Corticotropin-Releasing Hormone/metabolism , Hypothalamo-Hypophyseal System/metabolism , Interleukin-6/metabolism , Leukemia Inhibitory Factor , Leukemia Inhibitory Factor Receptor alpha Subunit , Mice , Mice, Mutant Strains , Mifepristone/pharmacology , Mutation , Pituitary Gland, Anterior/immunology , Pituitary-Adrenal System/metabolism , Pro-Opiomelanocortin/genetics , RNA, Messenger/analysis , RNA, Messenger/metabolism , Receptors, Corticotropin-Releasing Hormone/analysis , Receptors, Corticotropin-Releasing Hormone/metabolism , Receptors, Cytokine/genetics , Receptors, Glucocorticoid/metabolism , Receptors, Mineralocorticoid/metabolism , Receptors, OSM-LIF , Transcription, Genetic , Tumor Necrosis Factor-alpha/metabolism , Up-Regulation

ABSTRACT

Subject(s)

SEND TO:

SELECTION OF CITATIONS

SEARCH DETAIL