ABSTRACT
Progressive pseudorheumatoid dysplasia (PPD) is an autosomal recessive hereditary disease of very low prevalence. It is characterized by the affection of multiple joints, generating arthrosis and progressive deformities from a very young age, which significantly affect the quality of life of patients. Its diagnosis is only confirmed by genetic testing, and no specific pharmacological treatment is still available. In the case of hip involvement, one treatment option is arthroplasty. In this case report, we present a 15-year-old boy with bilateral coxarthrosis secondary to PPD who underwent bilateral total hip arthroplasty in two stages. We highlight the characteristics of this rare entity, the intraoperative findings, the functional outcomes, and the impact on quality of life.
La displasia progresiva pseudorreumatoide (DPP) es una enfermedad hereditaria autosómica recesiva, de muy baja prevalencia. Se caracteriza por la afección de múltiples articulaciones, generando artrosis y deformidades progresivas desde muy temprana edad, que afectan considerablemente la calidad de vida de los pacientes. Su diagnóstico sólo se confirma por análisis genéticos y aún no se dispone de tratamiento farmacológico específico. Ante la afectación de la cadera, una opción de tratamiento está representada por la artroplastía. En este reporte de caso, presentamos un joven de 15 años, con coxartrosis bilateral secundaria a DPP, al cual se le realizó una artroplastía total de cadera bilateral, en dos tiempos. Destacamos las características propias de esta extraña entidad, los hallazgos intraoperatorios, sus resultados funcionales y el impacto en la calidad de vida.
Subject(s)
Arthroplasty, Replacement, Hip , Humans , Adolescent , Male , Arthroplasty, Replacement, Hip/methods , Joint Diseases/surgery , Joint Diseases/congenitalABSTRACT
El presente trabajo tiene como objetivo el remplazo de piezas dentarias con indicación de extracción por implantes dentales de titanio, con la finalidad de devolver función y estética en forma inmediata respetando los tejidos periodontales y adaptando al máximo la clínica a las necesidades y requerimientos del paciente (AU)
Subject(s)
Humans , Male , Middle Aged , Minimally Invasive Surgical Procedures , Dental Implants, Single-Tooth , Immediate Dental Implant Loading , Patient Care Planning , Tooth Extraction , Wound Healing , Biotypology , Treatment Outcome , GingivectomyABSTRACT
We designed this study to determine whether the capacity of the liver to uptake ammonia and produce urea was affected by exercise (swimming at 24 degrees C with a 2.5% extra body-weight load). For this purpose, livers from sedentary rats at rest were perfused with a buffer containing increasing concentration of NH4Cl. The maximal hepatic capacity to produce urea was found at an NH4Cl concentration of 0.25 mM. Based on this finding all experiments with livers obtained from rats subject to swimming exercise were also carried out with a NH4Cl concentration of 0.25 mM. Thus, employing this concentration of ammonia, livers from sedentary and endurance trained rats, (for a period of 11 days ), that had either been resting or had been subjected to swimming exercise for 5 min or until exhaustion, were perfused in situ and ammonia uptake and urea production were measured. Clearly, both parameters were increased by exercise. However, these changes were not affected by swimming training. In addition, we demonstrate that the effect of an acute exercise on hepatic metabolism is not restricted to ammonia metabolism since livers from sedentary rats which had been subjected to swimming exercise for 5 min or until exhaustion showed higher urea production from L-glutamine. Our results also suggest that part of the changes in ureogenesis induced by exercise is mediated by cortisol (increased ammonia uptake) and part of the changes is mediated by glucagon (urea production).