ABSTRACT
No disponible
Subject(s)
Male , Infant , Humans , Coma/chemically induced , Cannabis/toxicity , Glasgow Coma ScaleABSTRACT
OBJECTIVE: The objective of this study was to evaluate if there is a correlation between blood levels of the enzyme neuron-specific enolase in children with non-traumatic acute encephalopathies with severe alterations in consciousness and the neurological sequellae. PATIENTS AND METHODS: Neuron-specific enolase (EC 4.2.1.11) activity in plasma was measured by radioimmunoassay in 9 children aged 7 months to 5 years, who suffered acute encephalopathy and coma of non-traumatic origin. The etiology was acute viral encephalitis (n = 4), near drowning (n = 2), shock (n = 2) and cardiac arrest (n = 1). Blood samples were obtained between 24 and 72 hours after the onset of encephalopathy. The neurological status was evaluated 18 months after the onset of encephalopathy in the 8 surviving patients (1 patient with brain death criteria died in the acute stage). RESULTS: Enzyme activities were significantly higher in the children who showed neurological sequelae (median 68.9 ng/ml, range 35.0-95.6, n = 4) than in those who did not present neurological abnormalities (median 15.8 ng/ml, range 9.7-18.7, n = 5), with p < 0.05. No differences were found between the latter and the control group (median 7.7 ng/ml, range 4.1-12.7, n = 10). CONCLUSIONS: It appears that the presence of elevated neuron-specific enolase in blood is predictive of neurological outcome in children with acute encephalopathies of non-traumatic origin.
Subject(s)
Brain Diseases/diagnosis , Clinical Enzyme Tests , Phosphopyruvate Hydratase/blood , Acute Disease , Biomarkers/blood , Brain Diseases/complications , Child , Child, Preschool , Clinical Enzyme Tests/statistics & numerical data , Female , Humans , Infant , Male , Prognosis , Statistics, NonparametricSubject(s)
Escherichia coli Infections/diagnosis , Magnetic Resonance Imaging , Meningitis, Bacterial/diagnosis , Spina Bifida Occulta/diagnosis , Combined Modality Therapy , Escherichia coli Infections/etiology , Escherichia coli Infections/therapy , Female , Humans , Infant , Meningitis, Bacterial/etiology , Meningitis, Bacterial/therapy , Spina Bifida Occulta/complications , Spina Bifida Occulta/therapySubject(s)
Benzodiazepines/poisoning , Flumazenil/therapeutic use , Poisoning/drug therapy , Antidotes , Child , Child, Preschool , Humans , MaleABSTRACT
A new case of atipic chondrodystrophies classified as tanatophoric dwarfism, with pathologic studies is presented. At the same time a revision of the most important works of literature is made. Genetic, clinic and pathologic aspects of the picture have being studied, presenting the differential diagnosis with other osteochondrodysplasias of the newborn.
